Preparation of biocompatible membranes by electrospinning

Chen, Jingwen; Tseng, Kuo-Feng; Delimartin, Swary; Lee, Cheng‐Kang; Ho, Ming‐Hua

doi:10.1016/j.desal.2007.09.026

Cited by 23 publications

(9 citation statements)

References 3 publications

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“…A solution jet is ejected towards the collector as the electric field intensifies. Nanofibers are formed upon the evaporation of the polymer solvent [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Adsorption and Photocatalytic Degradation of Malachite Green Using Electrospun P(3HB)-TiO₂Nanocomposite Fibers and Films

Sridewi

Lee

Sudesh

2011

International Journal of Photoenergy

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This paper demonstrated the applicability of electrospun P(3HB) film as a dye adsorbent agent. Malachite green (MG) was used as the model dye in this study. Interestingly, the electrospun P(3HB) film exhibited excellent dye adsorption capacity whereby 78% of dye was adsorbed from a 30 μM solution of MG. The film was further improvised by incorporating titanium dioxide photocatalysts to form a dual dye treatment system employing adsorption and photocatalytic degradation techniques. The resultant electrospun P(3HB)-50 wt% TiO2was capable of completely decolorizing MG in 45 min under solar irradiation, which corresponded to 58.7% COD removal. The fully decolorized MG solution also proved to be nontoxic againstA. aegyptimosquito larvae. The reapplicability of this film was possible as it induced a decolorization rate of 98% or more at every usage for ten consequent usages. EDX analysis suggested that there were no significant changes in the concentration of titanium (Ti) in the film before and after ten times of usage. The concentration of Ti in cast P(3HB)-50 wt% TiO2film was found to decrease significantly during the repeated usage. The electrospun P(3HB)-50 wt% TiO2film has high potency as an efficient and inexpensive yet simple method for the dye effluent decolorization, degradation, and detoxification.

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“…A solution jet is ejected towards the collector as the electric field intensifies. Nanofibers are formed upon the evaporation of the polymer solvent [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Adsorption and Photocatalytic Degradation of Malachite Green Using Electrospun P(3HB)-TiO₂Nanocomposite Fibers and Films

Sridewi

Lee

Sudesh

2011

International Journal of Photoenergy

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“…Our results indicate that a concentrated chitosan solution was beneficial for fabricating continuous and uniform nanofibers, which was in agreement with previous findings from the electrospinning of poly(lactic acid) and poly(ethylene oxide). 45,46 In addition, previous studies reported that there was a lower limit of chitosan concentrations for forming nanofibers because a low chitosan concentration was insufficient to provide intramolecular entanglement forces to maintain a continuous electrospinning jet. 43,44 The entanglement force increased with the polymer concentration that prevented the thinning process in the formation of nanofibers by resisting the repulsion Columbic forces in electrospinning.…”

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confidence: 99%

Chitosan nanofiber scaffold improves bone healing via stimulating trabecular bone production due to upregulation of the Runx2/osteocalcin/alkaline phosphatase signaling pathway

Yao

Liao

et al. 2015

IJN

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Osteoblasts play critical roles in bone formation. Our previous study showed that chitosan nanofibers can stimulate osteoblast proliferation and maturation. This translational study used an animal model of bone defects to evaluate the effects of chitosan nanofiber scaffolds on bone healing and the possible mechanisms. In this study, we produced uniform chitosan nanofibers with fiber diameters of approximately 200 nm. A bone defect was surgically created in the proximal femurs of male C57LB/6 mice, and then the left femur was implanted with chitosan nanofiber scaffolds for 21 days and compared with the right femur, which served as a control. Histological analyses revealed that implantation of chitosan nanofiber scaffolds did not lead to hepatotoxicity or nephrotoxicity. Instead, imaging analyses by X-ray transmission and microcomputed tomography showed that implantation of chitosan nanofiber scaffolds improved bone healing compared with the control group. In parallel, microcomputed tomography and bone histomorphometric assays further demonstrated augmentation of the production of new trabecular bone in the chitosan nanofiber-treated group. Furthermore, implantation of chitosan nanofiber scaffolds led to a significant increase in the trabecular bone thickness but a reduction in the trabecular parameter factor. As to the mechanisms, analysis by confocal microscopy showed that implantation of chitosan nanofiber scaffolds increased levels of Runt-related transcription factor 2 (Runx2), a key transcription factor that regulates osteogenesis, in the bone defect sites. Successively, amounts of alkaline phosphatase and osteocalcin, two typical biomarkers that can simulate bone maturation, were augmented following implantation of chitosan nanofiber scaffolds. Taken together, this translational study showed a beneficial effect of chitosan nanofiber scaffolds on bone healing through stimulating trabecular bone production due to upregulation of Runx2-mediated alkaline phosphatase and osteocalcin gene expressions. Our results suggest the potential of chitosan nanofiber scaffolds for therapy of bone diseases, including bone defects and bone fractures.

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“…Various results have been reported such as none of the aforementioned parameters making a difference to fiber diameter [7] to increased voltage increasing the fiber diameter and decreased voltage resulting in beading [14]. Theron et al [2] found that higher flow rates resulted in low residence time for the drop at the end of the needle, so voltage did not have enough time to take effect and increasing the working distance resulted in weakening of the applied electric field.…”

Section: Introductionmentioning

confidence: 96%

Controlling Fiber Morphology and Scaffold Design for Treatment of Dry Age-Related Macular Degeneration

Haneef

Downes

2014

International Journal of Polymeric Materials and Polymeric Biom

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Polystyrene (PS), poly(ethylene terephthalate) (PET), and polyurethane (PU) were electrospun in various solvents, to ascertain the ideal conditions for reproducible scaffold production, in order to develop a synthetic Bruch's membrane. Effects of different environmental factors under laboratory conditions and controlled conditions, with and without 1% NaCl, were investigated. For PS, environmental conditions were more important than NaCl addition in fiber diameter reduction; however, NaCl addition showed reduced fiber size variation. For PET, reduction in fiber diameter on addition of NaCl compared to controlled environmental conditions was observed. Fiber size variation for PET was unaffected by NaCl addition or controlled conditions.

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Preparation of biocompatible membranes by electrospinning

Cited by 23 publications

References 3 publications

Simultaneous Adsorption and Photocatalytic Degradation of Malachite Green Using Electrospun P(3HB)-TiO₂Nanocomposite Fibers and Films

Simultaneous Adsorption and Photocatalytic Degradation of Malachite Green Using Electrospun P(3HB)-TiO₂Nanocomposite Fibers and Films

Chitosan nanofiber scaffold improves bone healing via stimulating trabecular bone production due to upregulation of the Runx2/osteocalcin/alkaline phosphatase signaling pathway

Controlling Fiber Morphology and Scaffold Design for Treatment of Dry Age-Related Macular Degeneration

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Preparation of biocompatible membranes by electrospinning

Cited by 23 publications

References 3 publications

Simultaneous Adsorption and Photocatalytic Degradation of Malachite Green Using Electrospun P(3HB)-TiO2Nanocomposite Fibers and Films

Simultaneous Adsorption and Photocatalytic Degradation of Malachite Green Using Electrospun P(3HB)-TiO2Nanocomposite Fibers and Films

Chitosan nanofiber scaffold improves bone healing via stimulating trabecular bone production due to upregulation of the Runx2/osteocalcin/alkaline phosphatase signaling pathway

Controlling Fiber Morphology and Scaffold Design for Treatment of Dry Age-Related Macular Degeneration

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Simultaneous Adsorption and Photocatalytic Degradation of Malachite Green Using Electrospun P(3HB)-TiO₂Nanocomposite Fibers and Films

Simultaneous Adsorption and Photocatalytic Degradation of Malachite Green Using Electrospun P(3HB)-TiO₂Nanocomposite Fibers and Films