Preparation of Chitosan‐Alginate Nanoparticles for<i>Trans</i>‐cinnamaldehyde Entrapment

Loquercio, Andre; Castell‐Perez, Elena; Gomes, Carmen; Moreira, Rosana G.

doi:10.1111/1750-3841.12997

Cited by 56 publications

(47 citation statements)

References 31 publications

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“…Also, processing parameters including stirring, homogenization, sonication, and equilibration times are of important factors [57][58][59][60]. We attribute the low encapsulation efficiency of caffeine in our NC and NE systems to its hydrophilic character that has a very low affinity to Miglyol oil.…”

Section: Discussionmentioning

confidence: 99%

Chitosan encapsulation modulates the effect of trans-cinnamaldehyde on AHL-regulated quorum sensing activity

Qin

Kräft

Goycoolea

2018

Colloids and Surfaces B: Biointerfaces

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Section: Discussionmentioning

confidence: 99%

Chitosan encapsulation modulates the effect of trans-cinnamaldehyde on AHL-regulated quorum sensing activity

Qin

Kräft

Goycoolea

2018

Colloids and Surfaces B: Biointerfaces

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“…The reaction consists in a first step characterized by an interaction between alginate and calcium ions, due to the gelling properties of alginate for the presence of guluronic residues [ 196 ], that are able to exchange sodium ions with divalent cations such as Ca 2+ , Sr 2+ and Ba 2+ , forming the characteristic egg box structures. This step in the original study was followed by the crosslinking of pre-gelled alginate with poly-lysine, but in several subsequent works chitosan substituted poly-lysine [ 191 , 195 , 196 , 198 , 199 , 200 ]. Hyaluronan, another biocompatible polymer negatively charged that can be used to form complexes with chitosan [ 201 , 202 ] has the ability to bind several receptors as CD44 [ 203 ].…”

Section: Application Of Chitosan As Delivery Systemsmentioning

confidence: 99%

“The Good, the Bad and the Ugly” of Chitosans

et al. 2016

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The objective of this paper is to emphasize the fact that while consistent interest has been paid to the industrial use of chitosan, minor attention has been devoted to spread the knowledge of a good characterization of its physico-chemical properties. Therefore, the paper attempts to critically comment on the conflicting experimental results, highlighting the facts, the myths and the controversies. The goal is to indicate how to take advantage of chitosan versatility, to learn how to manage its variability and show how to properly tackle some unexpected undesirable features. In the sections of the paper various issues that relate chitosan properties to some basic features and to advanced solutions and applications are presented. The introduction outlines some historical pioneering works, where the chemistry of chitosan was originally explored. Thereafter, particular reference is made to analytical purity, characterization and chain modifications. The macromolecular characterization is mostly related to molecular weight and to degree of acetylation, but also refers to the conformational and rheological properties and solution stability. Then, the antimicrobial activity of chitosan in relation with its solubility is reviewed. A section is dedicated to the formulation of chitosan biomaterials, from gel to nanobeads, exploring their innovative application as active carrier nanoparticles. Finally, the toxicity issue of chitosan as a polymer and as a constructed nanomaterial is briefly commented in the conclusions.

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“…The method used was a modification of what is called the ionotropic pregelation method [43,44]. Solutions of CS, Alg and CaCl 2 were first prepared.…”

Section: Preparation Of Cs-alg Nanoparticles and Met-cs-algnps Nanocomentioning

confidence: 99%

A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design

et al. 2020

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The goal of this study was to develop and statistically optimize the metronidazole (MET), chitosan (CS) and alginate (Alg) nanoparticles (NP) nanocomposites (MET-CS-AlgNPs) using a (21 × 31 × 21) × 3 = 36 full factorial design (FFD) to investigate the effect of chitosan and alginate polymer concentrations and calcium chloride (CaCl2) concentration ondrug loading efficiency(LE), particle size and zeta potential. The concentration of CS, Alg and CaCl2 were taken as independent variables, while drug loading, particle size and zeta potential were taken as dependent variables. The study showed that the loading efficiency and particle size depend on the CS, Alg and CaCl2 concentrations, whereas zeta potential depends only on the Alg and CaCl2 concentrations. The MET-CS-AlgNPs nanocomposites were characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM) and in vitro drug release studies. XRD datashowed that the crystalline properties of MET changed to an amorphous-like pattern when the nanocomposites were formed.The XRD pattern of MET-CS-AlgNPs showed reflections at 2θ = 14.2° and 22.1°, indicating that the formation of the nanocompositesprepared at the optimum conditions havea mean diameter of (165±20) nm, with a MET loading of (46.0 ± 2.1)% and a zeta potential of (−9.2 ± 0.5) mV.The FTIR data of MET-CS-AlgNPs showed some bands of MET, such as 3283, 1585 and 1413 cm−1, confirming the presence of the drug in the MET-CS-AlgNPs nanocomposites. The TGA for the optimized sample of MET-CS-AlgNPs showed a 70.2% weight loss compared to 55.3% for CS-AlgNPs, and the difference is due to the incorporation of MET in the CS-AlgNPs for the formation of MET-CS-AlgNPs nanocomposites. The release of MET from the nanocomposite showed sustained-release properties, indicating the presence of an interaction between MET and the polymer. The nanocomposite shows a smooth surface and spherical shape. The release profile of MET from its MET-CS-AlgNPs nanocomposites was found to be governed by the second kinetic model (R2 between 0.956–0.990) with more than 90% release during the first 50 h, which suggests that the release of the MET drug can be extended or prolonged via the nanocomposite formulation.

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Preparation of Chitosan‐Alginate Nanoparticles forTrans‐cinnamaldehyde Entrapment

Cited by 56 publications

References 31 publications

Chitosan encapsulation modulates the effect of trans-cinnamaldehyde on AHL-regulated quorum sensing activity

Chitosan encapsulation modulates the effect of trans-cinnamaldehyde on AHL-regulated quorum sensing activity

“The Good, the Bad and the Ugly” of Chitosans

A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design

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