Preparation of chitosan biguanidine/PANI-containing self-healing semi-conductive waterborne scaffolds for bone tissue engineering

Shaabani, Alireza; Sedghi, Roya

doi:10.1016/j.carbpol.2021.118045

Cited by 39 publications

(27 citation statements)

References 39 publications

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“…The condensation of CS amines to aldehydes was vastly investigated for CS functionalization ( Scheme 5 ). Due to the reversibility of this reaction, the resulting CS imines often find applications in self-healing polymeric derivatives [ 43 , 75 ].…”

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

“…Other examples of CS-based imine systems were disclosed from reaction with nitriles [ 75 ] or as intermediates of irreversible transformations including Mannich reaction [ 84 ] or reductive amination [ 85 , 86 ]. The resulting systems showed enhanced stability.…”

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

“…The first step toward dual covalent/non-covalent CS-based materials generally makes use of covalent functionalization of the reactive CS amines. This initial modification of the CS backbone can add valuable properties such as improved solubility and increased bio-adhesion [ 147 ] and biocompatibility [ 75 ] to the final material. The number of modified glucosamine units is commonly expressed as the grafting degree (GD).…”

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 99%

“…Table 3 presents studies where CS is stepwise conjugated with a small molecule and further combined with natural or synthetic polymers to bring complementary properties to the final material. Relevant examples include gelatin (enhanced water solubility and water retention) [ 84 ], poly(aniline) (electroconductivity) [ 75 ], poly(dimethylaminoethyl methacrylate) (DMAEMA), and N,N-methylene bisacrylamide (BisAAm) copolymer (electrostatic interactions) [ 154 ]. In particular, gelatin and polyvinyl alcohol are a common combination found for tissue engineering applications.…”

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 99%

“…This phenomenon also occurs when air is injected in the solution [ 158 ]. Local variation in the properties of a heterogeneous gel was exploited in the work of Shaabani et al [ 75 ] for the successful preparation of a semi-conductive and self-healing scaffold for bone engineering applications. The study involved a ternary mixture composed of a bisguanidine-CS derivative, polyaniline (PANI), and a waterborne polyurethane-based polymer.…”

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 99%

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Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

2021

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Chitosan (CS) is a natural biopolymer that has gained great interest in many research fields due to its promising biocompatibility, biodegradability, and favorable mechanical properties. The versatility of this low-cost polymer allows for a variety of chemical modifications via covalent conjugation and non-covalent interactions, which are designed to further improve the properties of interest. This review aims at presenting the broad range of functionalization strategies reported over the last five years to reflect the state-of-the art of CS derivatization. We start by describing covalent modifications performed on the CS backbone, followed by non-covalent CS modifications involving small molecules, proteins, and metal adjuvants. An overview of CS-based systems involving both covalent and electrostatic modification patterns is then presented. Finally, a special focus will be given on the characterization techniques commonly used to qualify the composition and physical properties of CS derivatives.

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Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 99%

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 99%

Section: Combination Of Covalent and Non-covalent Modificationsmentioning

confidence: 99%

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Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

2021

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Shape‐memory Polymers for Tissue Engineering Applications

Zheng,

García‐García,

Moreno‐Benítez

et al. 2024

Stimuli‐Responsive Materials for Tissue Engineering

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PANI‐Modified Ti‐Doped CVD Diamond As Promising Conductive Platform to Mimic Bioelectricity Functions

Politi

Battistoni

Carcione

et al. 2021

Adv Materials Inter

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This study is devoted to synthesizing and modifying conductive Ti‐doped diamond (TiD) biosubstrates with polyaniline (PANI) to provide a soft interface with high ionic conductivity and charge storage capacity for developing advanced scaffolds and implantable electrode materials. The diamond supports are prepared by an ad‐hoc chemical vapor deposition methodology allowing for the synthesis and contemporary doping of diamond lattice. An optimized potentiostatic electropolymerization method assures the growth of a homogenous PANI coating on a diamond surface. Scanning electron microscopy, atomic force microscopy, Raman, and reflectance infrared spectroscopy characterizations guarantee the production of nanostructured diamond layers with high surface electrical conductivity and good phase quality as well as of a rough polymer film in the conductive emeraldine form. Cyclic voltammetry and electrochemical impedance spectroscopy measurements point out a quasi‐reversible electron transfer among polymer chains ruled by the bulky dodecyl sulfate anion chosen as polymer dopant. This induces a cation exchange with the solution upon backbone redox reactions. The capability of the PANI‐TiD system to transduce ionic current into electronic current and vice versa via redox reaction with the surroundings can be reliably exploited to reproduce electrical stimulation processes through which to mimic the original bioelectricity functions of the human body for advanced biomedical applications.

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Preparation of chitosan biguanidine/PANI-containing self-healing semi-conductive waterborne scaffolds for bone tissue engineering

Cited by 39 publications

References 39 publications

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

Shape‐memory Polymers for Tissue Engineering Applications

PANI‐Modified Ti‐Doped CVD Diamond As Promising Conductive Platform to Mimic Bioelectricity Functions

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