Preparation of Chitosan/Poly‐γ‐Glutamic Acid Polyelectrolyte Multilayers on Biomedical Metals for Local Antibiotic Delivery

Liu, W. C.; Wang, Huey‐Yuan; Wang, Anni; Tseng, Chih-Hsien; Liu, Hsuan‐Liang; Chung, Ren-Jei

doi:10.3390/met7100418

Cited by 6 publications

(1 citation statement)

References 34 publications

(23 reference statements)

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“…Moreover, tetracycline was released from C/PGA PEMs and inhibited the growth of E. coli. The results showed a useful platform for modulating the micro-environment for better cell adhesion and antibiotic delivery and could hold a great potential for surface modification and drug loading (Liu et al, 2017).…”

Section: Applications Of Surface Engineered Nano-cargos For Antibiotic Resistancementioning

confidence: 97%

Overcoming Multidrug Resistance in Bacteria Through Antibiotics Delivery in Surface-Engineered Nano-Cargos: Recent Developments for Future Nano-Antibiotics

Yang

et al. 2021

Front. Bioeng. Biotechnol.

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In the recent few decades, the increase in multidrug-resistant (MDR) bacteria has reached an alarming rate and caused serious health problems. The incidence of infections due to MDR bacteria has been accompanied by morbidity and mortality; therefore, tackling bacterial resistance has become an urgent and unmet challenge to be properly addressed. The field of nanomedicine has the potential to design and develop efficient antimicrobials for MDR bacteria using its innovative and alternative approaches. The uniquely constructed nano-sized antimicrobials have a predominance over traditional antibiotics because their small size helps them in better interaction with bacterial cells. Moreover, surface engineering of nanocarriers offers significant advantages of targeting and modulating various resistance mechanisms, thus owe superior qualities for overcoming bacterial resistance. This review covers different mechanisms of antibiotic resistance, application of nanocarrier systems in drug delivery, functionalization of nanocarriers, application of functionalized nanocarriers for overcoming bacterial resistance, possible limitations of nanocarrier-based approach for antibacterial delivery, and future of surface-functionalized antimicrobial delivery systems.

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Section: Applications Of Surface Engineered Nano-cargos For Antibiotic Resistancementioning

confidence: 97%

Overcoming Multidrug Resistance in Bacteria Through Antibiotics Delivery in Surface-Engineered Nano-Cargos: Recent Developments for Future Nano-Antibiotics

Yang

et al. 2021

Front. Bioeng. Biotechnol.

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Perforated polyester nanomebranes as templates of electroactive and robust free-standing films

Molina

Cuesta

Puiggalı́-Jou

et al. 2019

European Polymer Journal

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Robust and flexible free-standing films made of spin-coated poly(lactic acid) (PLA) and poly(3,4-ethylenedioxythiophene) (PEDOT) nanolayers have been prepared. A steel sheet coated with a sacrificial layer of PEDOT:poly(styrenesulfonate) (PSS) and a spincoated nanolayer of PLA was used as working electrode for the anodic polymerization of 3,4-ethylenedioxythiophene monomer. The latter was only successfully accomplished when rounded-shape nanoperforations of average diameter 4914 nm were introduced into PLA layers, which was achieved by combining the phase segregation processes undergone by immiscible PLA:poly(vinyl alcohol) (PVA) mixtures with selective solvent etching to remove PVA domains. Nanoperforations allowed the utilization of the semiconducting PEDOT:PSS sacrificial layer to immobilize the electropolymerized PEDOT chains. Morphological and topographical studies show the templating effect of PEDOT layers. In addition of flexibility and mechanical strength, free-standing 5-layered films present good electrochemical activity, evidencing their potential ability to reversibly exchange ions with the medium.These properties offer important advantages with respect to those of neat PLA and supported PEDOT films, as has been illustrated by cell culture and protein adsorption assays. Cell cultures evidenced the superior behavior of 5-layered films as bioactive platforms for fibroblast and epithelial cells proliferation, while adsorption assays reflected their potential as selective bioadhesive surfaces for protein separation.

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Synergistic impact of scan strategy and scan angles in laser powder bed fusion process on mechanical, tribological and cell viability properties of porous 316L SS structure

Prayer Riju,

Arulvel

2024

Materials Chemistry and Physics

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Preparation of Chitosan/Poly‐γ‐Glutamic Acid Polyelectrolyte Multilayers on Biomedical Metals for Local Antibiotic Delivery

Cited by 6 publications

References 34 publications

Overcoming Multidrug Resistance in Bacteria Through Antibiotics Delivery in Surface-Engineered Nano-Cargos: Recent Developments for Future Nano-Antibiotics

Overcoming Multidrug Resistance in Bacteria Through Antibiotics Delivery in Surface-Engineered Nano-Cargos: Recent Developments for Future Nano-Antibiotics

Perforated polyester nanomebranes as templates of electroactive and robust free-standing films

Synergistic impact of scan strategy and scan angles in laser powder bed fusion process on mechanical, tribological and cell viability properties of porous 316L SS structure

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