2021
DOI: 10.3390/molecules26072093
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Preparation of Co-Processed Excipients for Controlled-Release of Drugs Assembled with Solid Lipid Nanoparticles and Direct Compression Materials

Abstract: The purpose of the study was to develop a novel, directly compressible, co-processed excipient capable of providing a controlled-release drug system for the pharmaceutical industry. A co-processed powder was formed by adsorption of solid lipid nanoparticles (SLN) as a controlled-release film onto a functional excipient, in this case, dicalcium phosphate dihydrate (DPD), for direct compression (Di-Tab®). The co-processed excipient has advantages: easy to implement; solvent-free; industrial scaling-up; good rheo… Show more

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Cited by 4 publications
(1 citation statement)
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“…Some of the methods used for preparing co-processed excipients are spray drying, agglomeration, spheronization by extrusion, melt granulation, co precipitation, roller drying etc. The accessibility of nanotechnology extendschances to elaborate on novel coprocessed excipients [11].…”
Section: Introductionmentioning
confidence: 99%
“…Some of the methods used for preparing co-processed excipients are spray drying, agglomeration, spheronization by extrusion, melt granulation, co precipitation, roller drying etc. The accessibility of nanotechnology extendschances to elaborate on novel coprocessed excipients [11].…”
Section: Introductionmentioning
confidence: 99%