Preparation of collagen–chondroitin sulfate–hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro

Zhang, Ling; Li, Kuifeng; Xiao, Wenqian; Zheng, Li; Xiao, Yumei; Fan, Hongsong; Zhang, Xingdong

doi:10.1016/j.carbpol.2010.11.009

Cited by 151 publications

(79 citation statements)

References 51 publications

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“…Due to the large water absorption capacity, hydrogels are used in many products having importance in our daily life, including diapers, hair gels, sanitary napkins, sweat soaking body powder, sealing, artificial snow 8 , agriculture 9 , drug delivery systems 10 , pharmaceuticals 11 , biomedical applications 12 , tissue engineering and regenerative medicine 13,14 , wound dressing material 15 , separation of biomolecules or cells 16 , and barrier materials to regulate biological adhesion 17,18 .…”

Section: General Uses Of Hydrogelmentioning

confidence: 99%

Hydrogels:A Boon for Increasing Agricultural Productivity in Water-Stressed Environment

et al. 2016

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Status of water stress in IndiaIN India rainfed agro-ecologies contribute 60% of the net sown area, 100% of the forest and 66% of the livestock. About 84-87% of pulses and minor millets, 80% of horticulture, 77% of oilseeds, 66% of cotton and 50% of cereals are cultivated under this region 1 . The area under dryland condition is 85 m ha (60% of total cultivated area), which receives average annual rainfall less than 1150 mm. Also, more than 30% of total geographical area of the country comes under low rainfall (less than 750 mm). About 84 districts in India fall in the category of low rainfall area.India ranks 41st among 181 countries with regard to water stress, with average score of 4.2 on the 0-5 scale system. (Water stress measures how much water is withdrawn every year from rivers, streams and shallow aquifers for domestic, agricultural and industrial uses. Scores above 4 on a scale of 0-5 indicate that, for the average water user, more than 80% of the water available is withdrawn annually.) The 4.2 score indicates that India is in the high risk zone with regard to water stress 2 .

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Section: General Uses Of Hydrogelmentioning

confidence: 99%

Hydrogels:A Boon for Increasing Agricultural Productivity in Water-Stressed Environment

et al. 2016

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“…It was reported that the loose network in the hydrogel would result in a high brittleness [12]. In this study, the S sample with larger pores and looser network showed a low compressive modulus, while the distributed small and uniform pores in the T sample were attributed to the higher crosslinking density [41]. Furthermore, the higher crosslinking density and introduction of POSS resulted in the highest compress modulus in the deep hydrogel.…”

Section: Discussionmentioning

confidence: 85%

Photocrosslinked layered gelatin-chitosan hydrogel with graded compositions for osteochondral defect repair

Han

Yang

Zhao

et al. 2015

J Mater Sci: Mater Med

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A layered gelatin-chitosan hydrogel with graded composition was prepared via photocrosslinking to simulate the polysaccharide/collagen composition of the natural tissue and mimic the multi-layered gradient structure of the cartilage-bone interface tissue. Firstly, gelatin and carboxymethyl chitosan were reacted with glycidyl methacrylate (GMA) to obtain methacrylated gelatin (Gtn-GMA) and carboxymethyl chitosan (CS-GMA). Then, the mixed solutions of Gtn-GMA in different methacrylation degrees with CS-GMA were prepared to form the superficial, transitional and deep layers of the hydrogel, respectively under the irradiation of ultraviolet light, while polyhedral oligomeric silsesquioxane was introduced in the deep layer to improve the mechanical properties. Results suggested that the pore sizes of the superficial, transitional and deep layers of the layered hydrogel were 115 ± 30, 94 ± 34, 51 ± 12 μm, respectively and their porosities were all higher than 80 %. The compressive strengths of them were 165 ± 54, 565 ± 50 and 993 ± 108 kPa, respectively and the strain of the gradient hydrogel decreased along the thickness direction, similar to the natural tissue. The in vitro cytotoxicity results showed that the hydrogel had good cytocompatibility and the in vivo repair results of osteochondral defect demonstrated remarkable recovery by using the gradient gelatin-chitosan hydrogel, especially when the hydrogel loading transforming growth factor-β1. Therefore, it was suggested that the prepared layered gelatin-chitosan hydrogel in this study could be potentially used to promote cartilage-bone interface tissue repair.

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“…It was reported that stem cells commit to the directly differentiation lineage specified by matrix elasticity, which was differentiated into nerve cells with the elastic modulus from 0.1 to 1 KPa, muscle cell with 8 -17 KPa interval, and osteoblast with 25 -40 KPa [1]. Histological studies have shown that hard hydroxyapatite can induce bone formation [32], while soft collagen-based hydrogels can induce cartilage formation [33]. Shu Chien's team recently revealed that the hardness-induced MSCs differentiation may be associated with integrin activation and internalization at the adhesion sites within the phenomenon of cell experiments [34].…”

Section: The Effect Of Mechanical Propertiesmentioning

confidence: 99%

Tissue induction, the relationship between biomaterial’s microenvironment and mesenchymal stem cell differentiation

Xu¹,

Liao²,

Zhang³

et al. 2013

JBiSE

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Preparation of collagen–chondroitin sulfate–hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro

Cited by 151 publications

References 51 publications

Hydrogels:A Boon for Increasing Agricultural Productivity in Water-Stressed Environment

Hydrogels:A Boon for Increasing Agricultural Productivity in Water-Stressed Environment

Photocrosslinked layered gelatin-chitosan hydrogel with graded compositions for osteochondral defect repair

Tissue induction, the relationship between biomaterial’s microenvironment and mesenchymal stem cell differentiation

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