Preparation of composite membranes by atom transfer radical polymerization initiated from a porous support

Balachandra, Anagi M.; Baker, Gregory L.; Bruening, Merlin L.

doi:10.1016/j.memsci.2003.07.009

Cited by 83 publications

(44 citation statements)

References 58 publications

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“…Among these methods, surface grafting, which is initiated by the anchored initiators under high-energy radiations or catalysts, has been widely studied and applied for surface functionalization in many cases. Hydrophilic polymers such as polyethylene glycol (PEG) [35,36] and poly(hydroxyethyl methylacrylate) (PHEMA) [37,38] were grafted onto the membrane surfaces to improve the wettability and anti-fouling properties. The temperature-or pH-sensitive polymers, such as poly(N-isopropylacrylamide) (PNIPAM) [39,40] and polyacrylic acid (PAA) [41], were also grafted to make environmentally responsive membranes.…”

Section: Introductionmentioning

confidence: 99%

Surface engineering of polymer membranes via mussel-inspired chemistry

Yang

Luo

et al. 2015

Journal of Membrane Science

382

202

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Section: Introductionmentioning

confidence: 99%

Surface engineering of polymer membranes via mussel-inspired chemistry

Yang

Luo

et al. 2015

Journal of Membrane Science

382

202

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“…Polymeric tentacles with adsorptive functionality extend into the protein solution that fills the porous volume, providing a scaffold for protein molecules to adsorb. A variety of resin beads for column chromatography (Bowes et al, 2009;Franke et al, 2010;Ghose et al, 2007;Langford et al, 2007;Müller, 1986;Tao and Carta, 2008;Zhang and Sun, 2002) and macroporous membranes for membrane chromatography (Balachandra et al, 2003;Bhut et al, 2008;Bhut and Husson, 2009;He and Ulbricht, 2008;Singh et al, 2008;Tsuneda et al, 1995) have been modified with adsorptive polymeric tentacles. Incorporating polymeric tentacles into macroporous membranes has even greater importance since the surface area per volume of the membrane is much lower than a bed of resin particles (Bhut et al, 2010;Wang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The role of polymer nanolayer architecture on the separation performance of anion‐exchange membrane adsorbers: I. Protein separations

Bhut

Weaver

Carter

et al. 2011

Biotech & Bioengineering

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This contribution describes the preparation of strong anion-exchange membranes with higher protein binding capacities than the best commercial resins. Quaternary amine (Q-type) anion-exchange membranes were prepared by grafting polyelectrolyte nanolayers from the surfaces of macroporous membrane supports. A focus of this study was to better understand the role of polymer nanolayer architecture on protein binding. Membranes were prepared with different polymer chain graft densities using a newly developed surface-initiated polymerization protocol designed to provide uniform and variable chain spacing. Bovine serum albumin and immunoglobulin G were used to measure binding capacities of proteins with different size. Dynamic binding capacities of IgG were measured to evaluate the impact of polymer chain density on the accessibility of large size protein to binding sites within the polyelectrolyte nanolayer under flow conditions. The dynamic binding capacity of IgG increased nearly linearly with increasing polymer chain density, which suggests that the spacing between polymer chains is sufficient for IgG to access binding sites all along the grafted polymer chains. Furthermore, the high dynamic binding capacity of IgG (>130 mg/mL) was independent of linear flow velocity, which suggests that the mass transfer of IgG molecules to the binding sites occurs primarily via convection. Overall, this research provides clear evidence that the dynamic binding capacities of large biologics can be higher for well-designed macroporous membrane adsorbers than commercial membrane or resin ion-exchange products. Specifically, using controlled polymerization leads to anion-exchange membrane adsorbers with high binding capacities that are independent of flow rate, enabling high throughput. Results of this work should help to accelerate the broader implementation of membrane adsorbers in bioprocess purification steps.

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“…2), absorption bands at 1600.88, 1495.98, 1449.38 and 831.31 cm -1 showed the presence of disubstituted benzene ring. The absorption bands at 1178 & 1125 cm -1 revealed the presence of -SO 3 group of Na p-styrenesulfonate in the polymer 8 . …”

Section: Resultsmentioning

confidence: 96%

Surface Initiated ATRP: Synthesis and Characterization of Functional Polymers Grafted on Modified Cellulose Beads

Ashaduzzaman

Ishikura²,

Sakata³

et al. 2013

ILCPA

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Atom transfer radical polymerization (ATRP) was employed to synthesize novel polymer particles. The surface of porous polymeric cellulose beads was modified by sodium hydroxide, 2-chloromethyloxirane, ethylenediamine and 2-bromo-2-methylpropionyl bromide successively in order to activate the beads surface so that it can play an important role as an initiator for ATRP reaction. ATRP on the modified cellulose beads surface was carried out with styrene and sodium pstyrenesulphonate monomers in the presence of non aqueous and aqueous phases respectively. The polymer products on the substrate surface were characterized by elemental analysis (EA), attenuated total reflectance-infrared (ATR-IR) spectroscopy and carbon 13 -nuclear magnetic resonance ( 13 C-NMR).

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Preparation of composite membranes by atom transfer radical polymerization initiated from a porous support

Cited by 83 publications

References 58 publications

Surface engineering of polymer membranes via mussel-inspired chemistry

Surface engineering of polymer membranes via mussel-inspired chemistry

The role of polymer nanolayer architecture on the separation performance of anion‐exchange membrane adsorbers: I. Protein separations

Surface Initiated ATRP: Synthesis and Characterization of Functional Polymers Grafted on Modified Cellulose Beads

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