Preparation of covalently bonded silica-alginate hybrid hydrogels by SCHIFF base and sol-gel reactions

Hernández-González, Aurora C.; Téllez-Jurado, Lucía; Rodríguez‐Lorenzo, Luís M.

doi:10.1016/j.carbpol.2021.118186

Cited by 23 publications

(13 citation statements)

References 24 publications

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“…The cross‐linking reaction between OSA and SF occurs between the aldehyde group of OSA and the amino group of glycine or alanine of SF, thus forming a Schiff base structure, that is, the molecular chain of OSA and SF is connected by C=N bond. When Na 2 B 4 O 7 is added to the reaction system, on the one hand, the formation of complex between hydroxyl group of OA and borax resulted in increasing solubility of OA, on the other hand, Na 2 B 4 O 7 solution can provide alkaline environment with pH about 9.2, while Schiff base reaction is very easy to occur in alkaline environment 36,37 . The possible interaction mechanism is shown in Figure 6.…”

Section: Resultsmentioning

confidence: 99%

“…When Na 2 B 4 O 7 is added to the reaction system, on the one hand, the formation of complex between hydroxyl group of OA and borax resulted in increasing solubility of OA, on the other hand, Na 2 B 4 O 7 solution can provide alkaline environment with pH about 9.2, while Schiff base reaction is very easy to occur in alkaline environment. 36,37 The possible interaction mechanism is shown in Figure 6.…”

Section: Crosslinking Mechanism Of Osa and Sfmentioning

confidence: 99%

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Oxidized sodium alginate crosslinked silk fibroin composite scaffold for skin tissue engineering

Guo

Wang

et al. 2022

J Biomed Mater Res

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Engineering skin substitutes represent a prospective source of advanced therapy in repairing severe traumatic wounds. Sodium alginate (SA) and silk fibroin (SF) are natural biomaterials, which are widely used in tissue engineering and other fields because of their low price, high safety, and good biocompatibility. However, SA itself degrades slowly, its degradation mode is difficult to control, and the degradation products are difficult to remove from the body because of its high molecular weight.Therefore, the composite scaffolds were prepared by freeze-drying composite technology by using the Schiff base reaction between biocompatible SF and permeable oxidized sodium alginate (OSA). Sodium periodate was used as oxidant to modify SA. The results showed that higher oxidation degree of OSA could be obtained by increasing the proportion of oxidant, and the relative molecular weight of the oxidized products could also be reduced. The composite scaffolds were prepared by using sodium tetraborate as a crosslinking accelerator of the Schiff base reaction between OSA and SF. FT-IR confirmed that the Schiff base group appeared in the material. In vitro biodegradation experiments showed that the biodegradation of the composite scaffolds was controllable, and the cytocompatibility experiment showed that the composite scaffolds had good biocompatibility.

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Section: Resultsmentioning

confidence: 99%

Section: Crosslinking Mechanism Of Osa and Sfmentioning

confidence: 99%

Oxidized sodium alginate crosslinked silk fibroin composite scaffold for skin tissue engineering

Guo

Wang

et al. 2022

J Biomed Mater Res

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“…Studies have shown that the use of carboxylesterase acrylamide (CBAA) and calcium ion crosslinking can form a double crosslinked network in the sodium alginate hydrogel, and the sodium alginate hydrogel with double crosslinked network has better mechanical properties than the original hydrogel. 84,112,155 The use of special fabrication methods to make alginate hydrogels form honeycomb like special structures can also greatly improve the mechanical properties of materials. 123…”

Section: Mechanical Strengthmentioning

confidence: 99%

A review on the synthesis and development of alginate hydrogels for wound therapy

Cao

Cong

et al. 2023

J. Mater. Chem. B

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“…Polymer silica hybrid gels featuring both bioactivity and osteoconductive properties have experienced increasing research attention in recent years as biomaterials for bone tissue engineering [1][2][3][4]. In this sense, a broad range of organic polymers and biopolymers has been contemplated for the preparation of new hybrid silica gels, including collagen [5], gelatin [6], poly e-caprolactone [7], and also polysaccharides such as alginate [8], cellulose [9], and chitosan [10]. Among these organics chitosan (CS), a linear polysaccharide derived of chitin, composed of glucosamine and N-acetylglucosamine, has stimulated scientific research interest in the last two decades to investigate its use in biomedical applications [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Effect of Washing Treatment on the Textural Properties and Bioactivity of Silica/Chitosan/TCP Xerogels for Bone Regeneration

Pérez-Moreno

Reyes-Peces

Vilches-Pérez

et al. 2021

IJMS

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Silica/biopolymer hydrogel-based materials constitute very attractive platforms for various emerging biomedical applications, particularly for bone repair. The incorporation of calcium phosphates in the hybrid network allows for designing implants with interesting biological properties. Here, we introduce a synthesis procedure for obtaining silica–chitosan (CS)–tricalcium phosphate (TCP) xerogels, with CS nominal content varying from 4 to 40 wt.% and 10 to 20 wt.% TCP. Samples were obtained using the sol-gel process assisted with ultrasound probe, and the influence of ethanol or water as washing solvents on surface area, micro- and mesopore volume, and average pore size were examined in order to optimize their textural properties. Three washing solutions with different soaking conditions were tested: 1 or 7 days in absolute ethanol and 30 days in distilled water, resulting in E1, E7, and W30 washing series, respectively. Soaked samples were eventually dried by evaporative drying at air ambient pressure, and the formation of interpenetrated hybrid structures was suggested by Fourier transformed infrared (FTIR) spectroscopy. In addition the impact that both washing solvent and TCP content have on the biodegradation, in vitro bioactivity and osteoconduction of xerogels were explored. It was found that calcium and phosphate-containing ethanol-washed xerogels presented in vitro release of calcium (2–12 mg/L) and silicon ions (~60–75 mg/L) after one week of soaking in phosphate-buffered saline (PBS), as revealed by inductive coupled plasma (ICP) spectroscopy analysis. However, only the release of silicon was detected for water-washed samples. Besides, all the samples exhibited in vitro bioactivity in simulated body fluid (SBF), as well as enhanced in vitro cell growth and also significant focal adhesion development and maturation.

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Preparation of covalently bonded silica-alginate hybrid hydrogels by SCHIFF base and sol-gel reactions

Cited by 23 publications

References 24 publications

Oxidized sodium alginate crosslinked silk fibroin composite scaffold for skin tissue engineering

Oxidized sodium alginate crosslinked silk fibroin composite scaffold for skin tissue engineering

A review on the synthesis and development of alginate hydrogels for wound therapy

Effect of Washing Treatment on the Textural Properties and Bioactivity of Silica/Chitosan/TCP Xerogels for Bone Regeneration

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