Preparation of cross-linked guar gum nanospheres containing tamoxifen citrate by single step emulsion in situ polymer cross-linking method

Controlled release of tamoxifen citrate encapsulated in cross-linked guar gum nanoparticles

“…Blank(Drug-free) and drug loaded nanoparticles were prepared by oil in water(o/w) emulsion polymer cross-linking method [29]. After the mutual saturation of the two phases both the liquids, the solvent containing the drug and emulsifier and aqueous solution of polymer and stabilizer are in the state of thermodynamic equilibrium.…”

Novel nanoparticle materials for drug/food delivery-polysaccharides

“…Tamoxifen-loaded nanoparticles were prepared by Sarmah and coworkers based on guar gum, which is commonly used for colon specific drug delivery in the pharmaceutical industry [111,202]. As a breast cancer drug, mitoxantrone is positively charged and then has been encapsulated in chitosan-based nanoparticles by ion gelation method using sodium TPP as gelation agent, and obtaining an encapsulation efficacy of 98% [203].…”

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

“…Nanoparticles were obtained by o/w emulsification and in situ polymer cross-linking, using dichloromethane as the best solvent of the drug and glutaraldehyde as cross-linker agent during the process. An efficiency loading of 15% was obtained when dichloromethane was used as selected solvent (Sarmah et al, 2009). Recently, nanoparticles based on thiolated alginate (ALG-CYS) and disulfide bond reduced albumin (BSA-SH) have been synthesized by coacervation method and stabilized by disulfide bond formation between both polymers.…”