Preparation of Curcuma comosa tablets using liquisolid techniques: In vitro and in vivo evaluation

Jaipakdee, Napaphak; Limpongsa, Ekapol; Sripanidkulchai, Bungorn; Piyachaturawat, Pawinee

doi:10.1016/j.ijpharm.2018.10.031

Cited by 29 publications

(24 citation statements)

References 48 publications

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“…[51,52]). Products from rhizomes of C. comosa have been developed for use as an anti-inflammation remedy and for treatment of uterine abnormalities and ovarian hormone deficit [53,54]. [55]; b, Puangpairote [56]; c, Jenjittikul and Larsen [57]; d, Larsen [6]; e, Maknoi et al [49]; f, Boonma and Saensouk [48]; g, Chen et al [58]; and h, Puangpairote et al [59].…”

Section: The Genus Curcuma In Thailandmentioning

confidence: 99%

Polyploidy in the Ginger Family from Thailand

Anamthawat‐Jónsson¹,

Umpunjun²

2020

Chromosomal Abnormalities

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Polyploidy is common in the ginger family Zingiberaceae. The aims of the present paper are (1) to provide a general introduction on species diversity with emphasis on conservation; (2) to highlight the human-use significance of this family, focusing on the two major genera, Zingiber (ginger) and Curcuma (turmeric); (3) to present chromosome number data from 45 natural and cultivated Curcuma taxa from Thailand, of which polyploids are predominant; and (4) to describe our own work on cytotaxonomy of selected Thai Curcuma species. We obtained somatic chromosome numbers from root tips and analysed meiotic chromosome behaviour from flowers. We also used the molecular cytogenetic method of ribosomal gene mapping on chromosomes to infer mechanism of polyploidization and reveal genomic relationships among closely related species. The main results of our cytogenetic studies include the following. The most sought-after medicinal Curcuma cultivars growing on a large-scale basis are secondary triploids, so as taxa in natural habitats that are harvested for local utilisation. These triploids are sexually deficient, due to meiotic pairing abnormalities, but they are propagated asexually via rhizomes. The ribosomal mapping results indicate natural triploidization process via hybridisation, either within populations or across the species boundaries.

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Section: The Genus Curcuma In Thailandmentioning

confidence: 99%

Polyploidy in the Ginger Family from Thailand

Anamthawat‐Jónsson¹,

Umpunjun²

2020

Chromosomal Abnormalities

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“…This study introduced the potential of liquisolid tablets for formulation of viscous and oleoresins like natural crude extracts. 48 Pathak et al 2019 presented a path breaking study upon potential usage of many natural origin gums as matrices and carriers for liquisolid technology by modifying them as needed. This study indicated usage of modified polysaccharides as potential carriers which was achieved by modifying the natural gums viz.…”

Section: Usage Of Natural Polymers and In Herbal Formulationsmentioning

confidence: 99%

Liquisolid Technology: Preparation, Characterization and Applications

Gorle

Chopade

2020

J. Drug Delivery Ther.

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With the advent of high throughput screening, drugs are emerging to be more lipophilic and less hydrophilic. Liquisolid Technology aims at solubility enhancement of such entities via cosolvency concept in a relatively minimalistic setup where there is no need of sophisticated machinery and is cost effective. It involves constituting a drug into molecular dispersion via a non-volatile solvent and then transforming it into a dry looking, free flowing compressible powder. This article aims at mapping Liquisolid Technology where its preparation techniques and potential applications are reviewed. An overview of the performance of Liquisolid in areas of dissolution enhancement, zero order release, photostability enhancement, liquipellets and its role in natural product formulations is recorded for a number of drugs. Keywords: Liquisolid, Dissolution Enhancement, Flowability, Compressibility, Cosolvency

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“…Based on preliminary trials, the drug-loaded powders (GBD-MCC and GBD-LAC) were blended with the disintegrant (polyplasdone XL10), colloidal silicon dioxide, and magnesium stearate (see Table 1). [32][33][34] The powder mixtures were then compressed using a single-punch machine (Erweka) equipped with 8 mm biconvex punch to produce tablets of average weight 200±5 mg. Tablet hardness was adjusted to achieve a tablet friability of .1% and a disintegration time of .1 minute, thus resembling the reference commercial product (GBD-COM) Semi Daonil™. Formulations of unprocessed micronized GBD particles (GBD-MCC-MIC and GBD-LAC-MIC) were prepared similarly using raw micronized GBD suspensions instead of GBD nanosuspensions.…”

Section: Preparation Of Tablet Formulationsmentioning

confidence: 99%

<p>Engineering of solidified glyburide nanocrystals for tablet formulation via loading of carriers: downstream processing, characterization, and bioavailability</p>

Ali

Hanafy

Alqurshi

2019

IJN

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Introduction: Presenting poorly water-soluble drugs as nanoparticles has shown to be an effective technique in enhancing drug dissolution rate, intrinsic solubility, and thus oral bioavailability. Nevertheless, working with nanoparticles introduces many challenges, one of which is their physical instability. Formulating nanoparticles into a solid dosage form may overcome such challenges and thus unlock the potential benefits of nanosizing. Methods: The current work investigates the possibility of developing a novel solid dosage form, with enhanced dissolution rate, whereby nanocrystals (~400 nm) of the class II Biopharmaceutical Classification System drug, glyburide (GBD) were fabricated through combined precipitation and homogenization procedures. Using a novel, but scalable, spraying technique, GBD nanocrystals were loaded onto commonly used tablet fillers, water-soluble lactose monohydrate (LAC), and water insoluble microcrystalline cellulose (MCC). Conventional tableting processes were then used to convert the powders generated into a tablet dosage form. Results: Studies of redispersibility showed considerable preservation of size characteristics of GBD nanocrystals during downstream processing with redispersibility indices of 105 and 118 for GBD-LAC and GBD-MCC, respectively. Characterization by differential scanning calorimetry, powder X-ray diffraction, and scanning electron microscopy showed that the powders generated powders contained nanosized crystals of GBD which adhered to carrier surfaces. Powder flowability was characterized using Hausner ratio (HR) and Carr's index (CI). GBD-LAC-loaded particles exhibited poor flowability with CI and HR of 37.5% and 1.60, respectively, whilst GBD-MCC particles showed a slightly improved flowability with CI and HR of 26.47% and 1.36, respectively. The novel tablet dosage form met US Pharmacopeia specifications, including drug content, hardness, and friability. Conclusion: Higher dissolution rates were observed from the nanocrystal-based tablets compared to the microsized and commercial drug formulations. Moreover, the novel nanocrystal tablet dosage forms showed enhanced in vivo performance with area under the plasma concentrationtime curve in the first 24 hours values 1.97 and 2.24 times greater than that of marketed tablets.

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Preparation of Curcuma comosa tablets using liquisolid techniques: In vitro and in vivo evaluation

Cited by 29 publications

References 48 publications

Polyploidy in the Ginger Family from Thailand

Polyploidy in the Ginger Family from Thailand

Liquisolid Technology: Preparation, Characterization and Applications

<p>Engineering of solidified glyburide nanocrystals for tablet formulation via loading of carriers: downstream processing, characterization, and bioavailability</p>

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