Preparation of Emodin‐Polyethylene Glycol Composite Microparticles Using a Supercritical Antisolvent Process

Lang, Zhongmin; Hong, Hailong; Han, Limin; Zhu, Na; Suo, Quan‐Ling

doi:10.1002/ceat.201100188

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…Eudragit L100-55 allowed reaching a controlled release of NSAIDs, antibiotics, and bronchodilator drugs from SAS microspheres [44,104]. Until now, the SAS coprecipitation was attempted using other kinds of polymers, such as polyethylene glycol (PEG) [35,106,129,130], poly(lactide-co-glycolide) (PLGA) [36,37,109], ethyl cellulose (EC) [91,[100][101][102]105], HPMC [34,39,42,70,107], and poly(hydroxybutyrate-co-hydroxyvalerate (PHBV) [95,96,[131][132][133][134][135]. However, the use of these carriers must be further investigated, by changing the selected solvents or/and the operating conditions, because the morphology of the polymer/drug precipitated powder is not yet satisfactory.…”

Section: Sas Coprecipitation Of Active Compounds With Polymeric Carriersmentioning

confidence: 99%

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Franco

Marco

2020

Processes

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The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of different pathologies and to better the patient’s compliance. In this context, many active compounds have been micronized to enhance their dissolution rate and bioavailability. Aiming for more effective treatments with reduced side effects caused by drug overdose, the SAS polymer/active principle coprecipitation has mainly been proposed to offer an adequate drug release for specific therapy. The demand for new formulations with reduced side effects on the patient’s health is still growing; in this context, the SAS technique is a promising tool to solve existing issues in the biomedical field. This updated review on the use of the SAS process for clinical applications provides useful information about the achievements, the most effective polymeric carriers, and parameters, as well as future perspectives.

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Section: Sas Coprecipitation Of Active Compounds With Polymeric Carriersmentioning

confidence: 99%

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Franco

Marco

2020

Processes

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“…In this sense, several techniques based on supercritical technology, employing mainly carbon dioxide as either solvent or anti-solvent, have been developed to overcome the drawbacks of the traditional methods and to meet the current demands of pharmaceutical sector in view of growing interest in producing more sophisticated release systems. [17][18][19][20] Solution enhanced dispersion by supercritical fluid (SEDS) technology has been used to produce fine particles. 21 SEDS has been also used to micronize diverse materials, such as lactose, β-carotene, polymers, pharmaceuticals and composites.…”

Section: Introductionmentioning

confidence: 99%

Coprecipitation of safrole oxide with poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in supercritical carbon dioxide

Tenório‐Neto¹,

Silva²,

Cellet³

et al. 2013

J. Braz. Chem. Soc.

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5-(Oxiran-2-ilmetil)-1,3-benzodioxol ou epóxi-safrol (SO) vem sendo estudado ao longo dos anos devido a suas propriedades dependentes da concentração, como indução à apoptose e transdiferenciação celular. A coprecipitação do SO com um polímero biodegradável e biocompatível, poli(3-hidroxibutirato-co-3-hidroxivalerato) (PHBV), foi realizada utilizando a técnica de dispersão de solução aumentada por fluídos supercríticos (SEDS). Um planejamento fatorial 2 4-1 foi realizado para investigar os efeitos das condições experimentais (pressão, vazão de solução e de antissolvente e concentrações de PHBV e SO) na eficiência do processo e na morfologia dos coprecipitados. Para o material obtido SO/PHBV, foram observadas formas esféricas e fibrosas, sendo as morfologias dependentes das condições experimentais. Os mecanismos de liberação controlada de epóxi-safrol para os materiais esféricos foram diferentes dos materiais fibrosos. Análise térmica mostrou uma diminuição na temperatura de máxima velocidade de degradação (T max ) em relação ao PHBV, atribuída à presença de SO e à morfologia da amostra.In recent years, 5-(oxiran-2-ylmethyl)-1,3-benzodioxole or safrole oxide (SO) has been widely studied due to its concentration dependent properties, such as cellular apoptosis inducing activity and cell transdifferentiation. Coprecipitation of SO with a biodegradable and biocompatible polymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), were performed using solution enhanced dispersion by supercritical fluids technique (SEDS). A 2 4-1 factorial design was carried out to investigate the effect of processing parameters (pressure, solution flow, anti-solvent flow and concentrations of PHBV and SO) on the process efficiency and microparticle morphology. Both fibrous and spherical shapes were observed for coprecipitated SO/PHBV, which were dependent on the experimental-processing conditions. Controlled release mechanisms of SO to spherical materials were different from fibrous materials. Thermal analysis showed a decrease in the temperature of maximum weight loss rate (T max ) of PHBV, attributed to the presence of SO and sample morphology.

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Amoxicillin and Ethyl Cellulose Precipitation by Two Supercritical Antisolvent Processes

Montes

Nunes²,

Gordillo

et al. 2013

Chem Eng & Technol

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Composites of amoxicillin and ethyl cellulose in the micrometer range were precipitated by supercritical antisolvent (SAS) processes using carbon dioxide as antisolvent and a mixture of dichloromethane and dimethylsulfoxide as solvents. Morphologies and mean diameter ranges were analyzed by scanning electron microscopy. X‐ray photoelectron spectroscopy (XPS) and high‐performance liquid chromatography were carried out in order to ensure successful coprecipitation and to determine the amoxicillin contents in the final products. The SAS processes used differ mainly in the way in which the solutions are introduced: through a normal or a coaxial nozzle. The XPS results provided proof that amoxicillin was not distributed in the same way in all the samples. The release behavior of the composites obtained was evaluated in two biological fluids, i.e., simulated gastric and simulated intestinal fluids. The different systems led to the release of the drug in different ways; but in all cases slower solubilization was obtained than for the pure drug.

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Preparation of Emodin‐Polyethylene Glycol Composite Microparticles Using a Supercritical Antisolvent Process

Cited by 9 publications

References 23 publications

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Supercritical Antisolvent Process for Pharmaceutical Applications: A Review

Coprecipitation of safrole oxide with poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in supercritical carbon dioxide

Amoxicillin and Ethyl Cellulose Precipitation by Two Supercritical Antisolvent Processes

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