Preparation of gelatin hydrogels incorporating low-molecular-weight heparin for anti-fibrotic therapy

Saito, Takashi; Tabata, Yasuhiko

doi:10.1016/j.actbio.2011.10.025

Cited by 61 publications

(35 citation statements)

References 43 publications

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“…On the other hand, PBS was used as incubation medium to assess the cinnamaldehyde release and degradation process, because release and degradation process are influenced by water absorption in the initial stage . The use of PBS and HCl for accelerated degradation was based on previous research to release and degradation profiles and the validity of such an approach has already been confirmed in the area of polymer sciences …”

Section: Discussionmentioning

confidence: 99%

Preparation of a calcium carbonate‐based bone substitute with cinnamaldehyde crosslinking agent with potential anti‐inflammatory properties

Dewi

Ana

Jansen

2017

J Biomedical Materials Res

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Calcium sulfate (CS), also known as POP (Plaster of Paris) is a self-setting, biocompatible, and osteoconductive biomaterial with a long history for the treatment of skeletal defects. However, CS cements show a too fast resorption rate and are unable to provide a long-term 3D framework during the osteogenesis process. In our previous studies, it was found that the incorporation of CaCO and CaCO hydrogel provided enhanced mechanical and degradation properties of POP composites. Furthermore, it was also found that the use of cinnamaldehyde to crosslink CaCO hydrogel may have some advantages, for example to crosslink the hydrogel and to act as anti-inflammatory control agent. The objective of the current study was to evaluate the effect of adding cinnamaldehyde crosslinked CaCO hydrogel into POP on the diametral tensile strength, weight loss, age swelling, degradation, cinnamaldehyde release, and porosity. The following composites were prepared: POP/HCin-025 (25% addition of hydrogel microsphere) and POP/HCin-050 (50% addition of hydrogel microsphere). The composites were assessed on their diametral tensile strength, weight loss of the POP composite, age swelling, degradation of the hydrogel CaCO , cinnamaldehyde release, and porosity, as well as XRD-patterns and FT-IR spectra. It was confirmed from the study that incorporation of cinnamaldehyde into CaCO hydrogel system significantly increased the mechanical strength of the POP composite. Weight loss, swelling ratio in both acid to neutral pH, and biodegradability of the POP composites were controllable by the addition of cinnamaldehyde-CaCO hydrogel. Moreover, the cinnamaldehyde incorporated into the hydrogel was proven to be released in a controlled manner. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1055-1062, 2017.

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Section: Discussionmentioning

confidence: 99%

Preparation of a calcium carbonate‐based bone substitute with cinnamaldehyde crosslinking agent with potential anti‐inflammatory properties

Dewi

Ana

Jansen

2017

J Biomedical Materials Res

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“…Therefore, there have been several investigations of drug delivery materials demonstrating their feasibility in drug therapy 13) . Some previous reports have shown that DDS technology is necessary to enhance the therapeutic efficacy of various drugs 9,14,15) . In general, the DDS material should be degraded after the drug delivery has been achieved, as the in vivo persistence of delivery materials can induce inflammation and therapeutically unacceptable responses.…”

Section: Introductionmentioning

confidence: 99%

Controlled release of simvastatin from biodegradable hydrogels promotes odontoblastic differentiation

Miyazawa

Matsuno

Asano

et al. 2015

Dental Materials Journal

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The objective of this study was to investigate the odontoblastic differentiation of dental pulp stem cells (DPSC) by biodegradable hydrogels incorporating simvastatin micelles, both in vitro and in vivo. Simvastatin (ST) was incorporated into the micelles of gelatin grafted with L-lactic acid oligomers (LAo) to allow water-solubilization. The simvastatin-LAo-grafted gelatin (LAo-g-gelatin) micelles were mixed with gelatin, followed by chemical crosslinking to form gelatin hydrogels (ST Mi/GH). The ST Mi were released from the gelatin hydrogel granules (GH) through enzymatic degradation. The ST Mi enhanced alkaline phosphatase activity, calcium deposition, and bone morphogenic protein-2 secretion of DPSC. When implanted subcutaneously into mice, the ST Mi/GH treated group exhibited increased dentin sialoprotein and calcium deposition, compared with those treated with GH plus free ST. It is possible to achieve odontoblastic differentiation of DPSC through the controlled release of ST from GH.

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“…Degradation experiment done in this study was referred to some previous studies [8,9,10]. Scaffolds were incubated in NPR-DMEM for 1, 3, 6, 24, 48 and 72 hours.…”

Section: Degradation Experiments In Npr-dmemmentioning

confidence: 99%

Degradation profile and fibroblast proliferation on synthetic coral scaffold for bone regeneration

Mahanani¹,

Herningtyas²,

Bachtiar³

et al. 2016

AIP Conference Proceedings

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COLLECTIONS This paper was selected as Featured ARTICLES YOU MAY BE INTERESTED INChitosan-gelatine membrane construct with different cinnamaldehyde concentration as drug delivery system in oral cavity AIP Conference Proceedings 1755, 160006 (2016) 160007 (2016) At the request of all authors of the paper, and with the agreement of the Proceedings Editor, an updated version of this article was published on 27 November 2018. The original version supplied to AIP Publishing included an error in the name of an author, name was listed as Andika Dewi Ana rather than Ika Dewi Ana. This has been corrected in the updated and republished version. Abstract. For bone regeneration, one of the important key factors is the ability of the scaffold to be able to be degraded gradually at the implant side and the ability to provide a microenvironment for cells. No information available yet regarding our new synthetic coral scaffold. The purpose of this study was to observe the degradation profile and the human fibroblast gingiva proliferation on the synthetic coral scaffolds prepared from gelatin and calcium carbonate (CaCO3) in a various concentration of weight% wherein gelatin only (G) was used as a control. Scaffolds were incubated in non-phenol red DMEM for 1, 3, 6, 24, 48, and 72 h, then the supernatant was analyzed by spectrophotometer in 280 nm wavelength. After 72 hours, the degradation rate of the scaffold was accelerated using 1N HCl.The proliferation of human fibroblast gingiva was observed at 24, 48 and 72 hours after seeding 2.10 4 cells/well. A plate of 96 well and DMEM were used in this study. The degradation percentage of the scaffolds within 24 hours was considered small, ranging between 4.23 -5.15%. Meanwhile, the degradation between 24 to 72 hours incubation was confirmed at 38. 35, 62.16, 52.86, 47.86, 48.42, and 53.17% for G, 7/3, 6/4, 5/5, 4/6 and 3/7 respectively. In the accelerated condition, the fastest degradation was found in G.Fibroblast proliferation increased following the incubation time except in control group and 3:7, but no significantly different between the various concentration. The fastest degradation rate was found in the scaffold without CaCO3 addition, confirming that CaCO3 in certain concentration prolonged the half-life of the scaffold. The proliferation of fibroblast is increased for all incubation time. Degradation Profile and Fibroblast Proliferation on Synthetic Coral Scaffold for Bone Regeneration

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Preparation of gelatin hydrogels incorporating low-molecular-weight heparin for anti-fibrotic therapy

Cited by 61 publications

References 43 publications

Preparation of a calcium carbonate‐based bone substitute with cinnamaldehyde crosslinking agent with potential anti‐inflammatory properties

Preparation of a calcium carbonate‐based bone substitute with cinnamaldehyde crosslinking agent with potential anti‐inflammatory properties

Controlled release of simvastatin from biodegradable hydrogels promotes odontoblastic differentiation

Degradation profile and fibroblast proliferation on synthetic coral scaffold for bone regeneration

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