Preparation of gelatin/poly(vinyl alcohol) film modified by methyl methacrylate and gamma irradiation

Dafader, N. C.; Rahman, Syeda Tania; Rahman, Wasikur; Rahman, Nazia; Manir, M.S.; Alam, Md. Ferdous; Alam, Jahangir; Sumi, Sumaia Aktar

doi:10.1080/1023666x.2016.1176638

Cited by 9 publications

(7 citation statements)

References 42 publications

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“…This is in agreement with the results reported by Zhang et al, who demonstrated an elevated thermal decomposition temperature upon blending ethylcellulose with poly(propylene carbonate) . The third ( T > 380 °C) stage was attributed to the carbonation reactions …”

Section: Results and Discussionsupporting

confidence: 93%

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Tunable Physical Properties of Ethylcellulose/Gelatin Composite Nanofibers by Electrospinning

Liu

Deng

Zhang

et al. 2018

J. Agric. Food Chem.

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In this work, the ethylcellulose/gelatin blends at various weight ratios in water/ethanol/acetic acid solution were electrospun to fabricate nanofibers with tunable physical properties. The solution compatibility was predicted based on Hansen solubility parameters and evaluated by rheological measurements. The physical properties were characterized by scanning electron microscopy, porosity, differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy, and water contact angle. Results showed that the entangled structures among ethylcellulose and gelatin chains through hydrogen bonds gave rise to a fine morphology of the composite fibers with improved thermal stability. The fibers with higher gelatin ratio (75%), possessed hydrophilic surface (water contact angle of 53.5°), and adequate water uptake ability (1234.14%), while the fibers with higher ethylcellulose proportion (75%) tended to be highly water stable with a hydrophobic surface (water contact angle of 129.7°). This work suggested that the composite ethylcellulose/gelatin nanofibers with tunable physical properties have potentials as materials for bioactive encapsulation, food packaging, and filtration applications.

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Section: Results and Discussionsupporting

confidence: 93%

“…14 The third (T > 380 °C) stage was attributed to the carbonation reactions. 37 The DSC results were shown in Figure 3B and Table 4. The broad endothermic peak, due to evaporation of volatiles or bound water, was termed as dehydration event (E D ).…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Tunable Physical Properties of Ethylcellulose/Gelatin Composite Nanofibers by Electrospinning

Liu

Deng

Zhang

et al. 2018

J. Agric. Food Chem.

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“…The surface of PG9 appeared homogeneous, smooth, nonporous, and compact. The absence of cracks on the film surface has been related to high flexibility . For effective wound dressing, surface integrity is critical, as it hinders entry of infectious microorganisms.…”

Section: Resultsmentioning

confidence: 99%

“…The absence of cracks on the film surface has been related to high flexibility. 58 For effective wound dressing, surface integrity is critical, as it hinders entry of infectious microorganisms. The PGC4 surface also did not appear any different from the PG9, thus confirming that the drug was homogeneously dispersed in the film matrix without disturbing the 3D network of the hydrogel film.…”

Section: Resultsmentioning

confidence: 99%

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

et al. 2023

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Curcumin (Cur) entrapped poly(vinyl alcohol) (PVA)/gelatin composite films were prepared by cross-linking with tannic acid (TA) as bioactive dressings for rapid wound closure. Films were evaluated for mechanical strength, swelling index, water vapor transmission rate (WVTR), film solubility, and in-vitro drug release studies. SEM revealed uniform and smooth surfaces of blank (PG9) and Cur-loaded composite films (PGC4). PGC4 exhibited excellent mechanical strength (tensile strength (TS) and Young’s modulus (YM) were 32.83 and 0.55 MPa, respectively), swelling ability (600–800% at pH 5.4, 7.4, and 9), WVTR (2003 ± 26), and film solubility (27.06 ± 2.0). Sustained release (81%) of the encapsulated payload was also observed for 72 h. The antioxidant activity determined by DPPH free radical scavenging showed that the PGC4 possessed strong % inhibition. The PGC4 formulation displayed higher antibacterial potential against S. aureus (14.55 mm zone of inhibition) and E. coli (13.00 mm zone of inhibition) compared to blank and positive control by the agar well diffusion method. An in-vivo wound healing study was carried out on rats using a full-thickness excisional wound model. Wounds treated with PGC4 showed very rapid healing about 93% in just 10 days post wounding as compared to 82.75% by Cur cream and 80.90% by PG9. Furthermore, histopathological studies showed ordered collagen deposition and angiogenesis along with fibroblast formation. PGC4 also exerted a strong anti-inflammatory effect by downregulating the expression of pro-inflammatory cytokines (TNF-α and IL-6 were lowered by 76% and 68% as compared to the untreated group, respectively). Therefore, Cur-loaded composite films can be an ideal delivery system for effective wound healing.

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“…When the skin is damaged under the circumstances of injury, disease, and strenuous exercise, it repairs itself to restore original state through a complex cascade of biochemical and cellular events including hemostasis, inflammation, proliferation, and maturation. , However, there is a need to design a wound dressing material to accelerate wound healing and restore normal skin integrity in the case of serious wound. Initially, a number of synthetic and naturally available macromolecules have been investigated as wound dressing material in different forms such as fiber, film, and gel. − Later on, researchers were inclined to prepare hybrid composites to enhance physicochemical properties such as air permeability, hydrophilicity, tensile strength, elasticity, and biodegradation of wound dressing material to create a benign environment around the wound site. − …”

Section: Introductionmentioning

confidence: 99%

Gelatin–Cerium Oxide Nanocomposite for Enhanced Excisional Wound Healing

Raja

Fathima

2018

ACS Appl. Bio Mater.

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Researchers are keen on formulating composites blending biomacromolecules with functional nanoparticles to achieve greater efficacy to expedite the wound healing process. In the present work, we have engineered a genipin cross-linked gelatin hydrogel composite containing optimized concentration of cerium oxide nanoparticles (G-ONp) for the purpose of wound healing. The concentration of cerium oxide nanoparticles in G-ONp has been optimized to be 250 μg/mL, which shows more than 80% cell viability in cytotoxicity study. X-ray diffractogram of ONp displays characteristic lattice planes of cubic fluorite structure, and transmission electron micrograph reveals that the particles are sized between 2.5−6.5 nm. The genipin dimeric crosslinkage in G-ONp has been confirmed by UV−vis peak at 603 nm. Swelling ratio of G-ONp (25.3 ± 1.2) has been found to be three-fold to that of native gelatin (9.2 ± 1.4). As far as pore size distribution is concerned, lyophilized sponges of gelatin and G-ONp had microsized pores in the range of 1−140 μm and 1−19 μm, respectively, and hydrogels of the same determined by thermoporometry had nanosized pores in the range of 7−48 nm and 7− 24 nm, respectively. The in vivo wound healing and histological examination have revealed that G-ONp treated rat group has shown more infiltration of leukocytes and larger deposition of collagen when compared to gelatin and control groups and has healed the wound in 12 days. These findings suggest that the composite of G-ONp is superior to gelatin in increasing wound healing and can be envisaged as a wound dressing material in future.

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Preparation of gelatin/poly(vinyl alcohol) film modified by methyl methacrylate and gamma irradiation

Cited by 9 publications

References 42 publications

Tunable Physical Properties of Ethylcellulose/Gelatin Composite Nanofibers by Electrospinning

Tunable Physical Properties of Ethylcellulose/Gelatin Composite Nanofibers by Electrospinning

Curcumin-Loaded Bioactive Polymer Composite Film of PVA/Gelatin/Tannic Acid Downregulates the Pro-inflammatory Cytokines to Expedite Healing of Full-Thickness Wounds

Gelatin–Cerium Oxide Nanocomposite for Enhanced Excisional Wound Healing

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