Preparation of graded porous titanium coatings on titanium implant materials by plasma spraying

Yang, Yunzhi; Tian, Jiemo; Tian, Jing; Chen, Z. Q.; Deng, Xiaojuan; Zhang, D. H.

doi:10.1002/1097-4636(200011)52:2<333::aid-jbm12>3.3.co;2-k

Cited by 19 publications

(24 citation statements)

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“…However, to the current authors' knowledge, such a high level of roughness has not been investigated in cells, and a R a of 37.9 m is the highest reported in in vivo studies, 14,38 even though materials with a surface roughness of about 100 m have been developed. 39 In conclusion, as expected, surface morphology and the presence of a ceramic coating strongly affected cell behavior. However, values of roughness that overcome specific limits are not correctly seen by cells.…”

Section: Discussionsupporting

confidence: 69%

Physical characterization of different‐roughness titanium surfaces, with and without hydroxyapatite coating, and their effect on human osteoblast‐like cells

et al. 2005

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The aim of this study was to characterize and compare various titanium (Ti) and hydroxyapatite (HA) coatings on Ti6Al4V, in view of their application on noncemented orthopedic implants. Two innovative vacuum plasma sprayed (VPS) coatings, the first of ultrahigh rough and dense Ti (PG60, Ra=74 microm) and the second of ultrahigh rough and dense Ti coated with HA (HPG60, Ra=52 microm), have been developed, and the response of osteoblast-like cells (MG-63) seeded on these new coatings was evaluated in comparison to: a low roughness and sandblasted (Ti/SA, Ra=4 microm) Ti6Al4V surface; Ti medium (TI01, Ra=18 microm), and high (TI60, Ra=40 microm) roughness VPS coatings; and the relative Ti plus HA duplex coatings (HT01, Ra=12 microm and HT60, Ra=36 microm respectively), also obtained by VPS. PG60 coating presented no open porosity, making it dense and potentially intrinsically stronger. Cell adhesion and proliferation on PG60 was similar to those of the smoothest one (Ti/SA) and adhesion on ultrahigh roughness was lower than the medium- and high-roughness coatings, whereas cell proliferation on PG60 was lower than TI60. The HA coating determined significant increases in cell proliferation at medium and high roughness levels when compared to the relative Ti coating, but not compared to the ultrahigh one; all HA-coated surfaces showed a decrease in alkaline phosphatase activity and collagen I production. Surface morphology and the HA coating strongly affected cell behavior. However, ultrahigh values of roughness are not correctly seen by cells, and the presence of HA has no improving effects.

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Section: Discussionsupporting

confidence: 69%

Physical characterization of different‐roughness titanium surfaces, with and without hydroxyapatite coating, and their effect on human osteoblast‐like cells

et al. 2005

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“…However, systemic use of Sr may cause some side effects such as drug rash with eosinophilia, toxic epidermal necrolysis and systemic syndrome (Pernicova et al 2008). Recently, Sr is generally locally applied to Ti implants through various methods such as plasma spraying (Yang et al 2000), sol-gel coatings (Li et al 2010), microarc oxidation (Yan et al 2013), magnetron co-sputtering (Andersen et al 2013) and electrochemical deposition (Liang et al 2014). The Sr coatings produced by the aforementioned methods can improve bone formation and osseointegration as expected, but several problems have been reported about coating itself.…”

Section: Discussionmentioning

confidence: 99%

Positive effect of strontium‐oxide layer on the osseointegration of moderately rough titanium surface in non‐osteoporotic rabbits

Fan

Chen

et al. 2016

Clinical Oral Implants Res

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“…In fact, this buffered transition from porous to dense is very similar to graded porous titanium which consists of three layers with graded porosities. 24,25 This gradual change in porosity means that the Young's modulus of the material will be better adapted to the elastic properties of bone compared to solid metals, thus reducing stress shielding between the implant and the bone which has been stated in the introduction part. Nevertheless, systematic mechanical tests are needed to prove the biomechenical advantages; also, further improvement accompanied by the fabrication skill adaptation should be carried out.…”

Section: Discussionmentioning

confidence: 99%

A new implant with solid core and porous surface: The biocompatability with bone

Yang

Wang

Liang

et al. 2013

J Biomedical Materials Res

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This research investigated osteogenic potencies of Farthing-Fray-Chen Titanium (FFcTi) implant with transitional porous-solid structure. The material characteristics, biomechanical property, osteogenic performances were assessed. FFcTi showed similar roughness as sand-blasted and acid etched titanium (SA), but was more hydrophilic than SA and machined commercial pure titanium (MA). Young's modulus of FFcTi implant in compressive tests was 15.8 ± 6.3 GPa, which was close to bone. In vitro observations manifested excellent spreading abilities of MC3T3-E1 cell on FFcTi and SA. Adhesion rates of MC3T3-E1 cells at 4 h gradually decreased on MA, SA, and FFcTi surfaces (MA > SA, p < 0.01; SA > FFcTi, p < 0.05), while cell proliferation ability on FFcTi was weaker than MA during 1-6 days (p < 0.01) and similar to MA and SA in day 11. ALP activity of cells on FFcTi at 14 day was higher than MA and lower than SA (p < 0.01). In a bone defect model of rabbits, BIC and bone volum ratio within 50 μm were significantly higher for FFcTi than MA (BIC, p < 0.01; BT0.05, p < 0.05) while bone volume ratio within 100 and 500 μm were of no differences. Micro CT analysis also showed similar results to the histomorphometric data. Thus, we conclude that FFcTi with melting sphere based multiporous structure has a hydrophilic, rough surface, and close modulus to bone. In vitro, its low proliferation and ALP activity promotion were similar to other micro scale roughed surface. In vivo test showed better osteogenesis ability when compared with MA at least in 2 weeks. Thus, this Farthing-Fray-Chen Titanium implant seems to hold considerable potential for bone implant applications.

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Preparation of graded porous titanium coatings on titanium implant materials by plasma spraying

Cited by 19 publications

References 0 publications

Physical characterization of different‐roughness titanium surfaces, with and without hydroxyapatite coating, and their effect on human osteoblast‐like cells

Physical characterization of different‐roughness titanium surfaces, with and without hydroxyapatite coating, and their effect on human osteoblast‐like cells

Positive effect of strontium‐oxide layer on the osseointegration of moderately rough titanium surface in non‐osteoporotic rabbits

A new implant with solid core and porous surface: The biocompatability with bone

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