2021
DOI: 10.1021/acsbiomaterials.1c00284
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Preparation of Heat-Denatured Macroaggregated Albumin for Biomedical Applications Using a Microfluidics Platform

Abstract: Albumin is widely used in pharmaceutical applications to alter the pharmacokinetic profile, improve efficacy, or decrease the toxicity of active compounds. Various drug delivery systems using albumin have been reported, including microparticles. Macroaggregated albumin (MAA) is one of the more common forms of albumin microparticles, which is predominately used for lung perfusion imaging when labeled with radionuclide technetium-99m (99mTc). These microparticles are formed by heat-denaturing albumin in a bulk s… Show more

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Cited by 2 publications
(5 citation statements)
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“…Following an IV bolus, 67 Ga-NOTA-IDR-1002 was rapidly cleared at the 2.2 mg/kg dose level, which is in line with our previous work with radiolabeled IDR-1018 as well as the broader HDP literature. Acute respiratory toxicity and enhanced lung uptake were observed upon IV dose escalation of 67 Ga-NOTA-IDR-1002 in a similar manner as with IDR-1018 . Although the exact reasons for IDR-1002 toxicity was not explored further here, it may be due to lytic disruption of the blood/air exchange surfaces or embolic effects due to the peptide precipitating in the blood. , Both IDR-1002 and IDR-1018 displayed toxicity at relatively lower doses compared to other IDR peptides given intravenously, such as HH-2 (8 mg/kg in mice), IDR-1 (100 mg/kg in mice) and IMX942 (8 mg/kg in man) . The reason for these differences is poorly understood and warrants further investigation.…”
Section: Discussionsupporting
confidence: 83%
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“…Following an IV bolus, 67 Ga-NOTA-IDR-1002 was rapidly cleared at the 2.2 mg/kg dose level, which is in line with our previous work with radiolabeled IDR-1018 as well as the broader HDP literature. Acute respiratory toxicity and enhanced lung uptake were observed upon IV dose escalation of 67 Ga-NOTA-IDR-1002 in a similar manner as with IDR-1018 . Although the exact reasons for IDR-1002 toxicity was not explored further here, it may be due to lytic disruption of the blood/air exchange surfaces or embolic effects due to the peptide precipitating in the blood. , Both IDR-1002 and IDR-1018 displayed toxicity at relatively lower doses compared to other IDR peptides given intravenously, such as HH-2 (8 mg/kg in mice), IDR-1 (100 mg/kg in mice) and IMX942 (8 mg/kg in man) . The reason for these differences is poorly understood and warrants further investigation.…”
Section: Discussionsupporting
confidence: 83%
“…SPECT/CT imaging was conducted and analyzed as previously described , using a MILabs VECTor platform outfitted with an extra-ultrahigh sensitivity mouse pinhole collimator (MILabs; Houten, The Netherlands). , Acquisition times and details are provided in Supplemental Table 2. SPECT data was reconstructed using U-SPECT Rec2.5li software (MILabs) on the gallium-67 photopeak of 96 ± 20 keV and SkyScan NRecon software (Micro Photonics Inc.) for the CT file.…”
Section: Methodsmentioning
confidence: 99%
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“…Albumin is a plasma protein found in lymph, saliva, cerebrospinal cord, and interstitial fluid, involved in the transport and dissolution of endogenous compounds, thereby regulating the osmotic pressure of the blood [48,49]. Albumin is well-known for its ability to specifically target tumour regions due to enhanced permeability and retention (EPR) effect as well as albumin receptor binding, which is a unique advantage as the carrier for tumour-targeted drug delivery [50].…”
Section: Introductionmentioning
confidence: 99%