Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers

Zhao, Jian; Liu, Changsheng; Yuan, Yuan; Tao, Xinyi; Shan, Xiaoqian; Yan, Sheng; Wu, Fan

doi:10.1016/j.biomaterials.2006.10.012

Cited by 94 publications

(96 citation statements)

References 25 publications

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“…This is illustrated in Suppose nanoparticles are prod with an iron core, which can b acquire a high affinity to oxygen hence trap oxygen atoms, for e the core has a porous str appropriate pore size, shape, an volume ratio [135]. The iron nan are then coated with biocompa (with reduced toxicity and wettability) and finally bio-conj attaching specific molecules that nano-particles can be delivered t minimising dissolution during nanoparticles can then release he nanoparticles are attached, by m site of a tumour tissue or an infe pathogens.…”

Section: Synergy In Reaction Chemistrmentioning

confidence: 99%

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

109

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To cite this version:M G Kong, M Keidar, K Ostrikov. Plasmas meet nanoparticleswhere synergies can advance the frontier of medicine. Journal of Physics D: Applied Physics, IOP Publishing, 2011, 44 (17) AbstractNanoparticles and low-temperature plasmas have been developed, independently and often along different routes, to tackle the same set of challenges in biomedicine. There are intriguing similarities and contrasts in their interactions with cells and living tissues, and these are reflected directly in the characteristics and scope of their intended therapeutic solutions, in particular their chemical reactivity, selectivity against pathogens and cancer cells, safety to healthy cells and tissues, and targeted delivery to diseased tissues. Time has come to ask the inevitable question of possible plasma-nanoparticle synergy and the related benefits to the development of effective, selective, and safe therapies for modern medicine. This perspective article offers a detailed review of the strengths and weakenesses of nanomedicine and plasma medicine as a stand-alone technology, and then provides a critical analysis of some of the major opportunities enabled by synergising the nanotechnology and the plasma technology. It is shown that the plasma-nanoparticle synergy is best captured through the plasma nanotechnology and its benefits for medicine are highly promising.

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Section: Synergy In Reaction Chemistrmentioning

confidence: 99%

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

109

View full text Add to dashboard Cite

show abstract

“…The delivery of oxygen has been examined in various studies Burkard, 1996, Burkard and Hemoglobin-loaded particles (Hb-particles) encapsulated within a biodegradable polymer have been prepared for use as oxygen carriers (Zhao et al, 2007). The Hb-particles exhibited oxygen-carrying capacity similar to that of native hemoglobin and showed prolonged circulation time after in vivo administration in mice.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of dextran nanobubbles for oxygen delivery

Cavalli

Bisazza

Giustetto

et al. 2009

International Journal of Pharmaceutics

117

109

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“…Quantitative analysis of NPs in different tissue and blood was done as per the previous report with slight modification (Zhao et al, 2007). Tissues were homogenized in distilled water followed by extraction in acetonitrile (for 18 h at 25 C).…”

Section: In Vivo Fate Of Nps After Oral Administrationmentioning

confidence: 99%

Improved oral efficacy of epirubicin through polymeric nanoparticles: pharmacodynamic and toxicological investigations

et al. 2016

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Epirubicin (EPI) elicits poor-oral bioavailability hence commercially available as injection for intravenous administration which follows a rapid increase and fast decay in plasma drug concentration often needs a frequent dosing that may lead to serious side effects. Aim of the present study is to develop a nanoparticulate system which could deliver epirubicin effectively via oral administration and could eventually promote new concept ''chemotherapy at home.'' In this perspective, epirubicin loaded Poly-lactide-co-glycolic acid nanoparticles (EPI-NPs) were developed by double emulsion evaporation techniques and evaluated for its safety and efficacy against Ehrlich's Ascites (EAT) induced tumor in balb/c mice. In vivo fate of nanoparticles after oral administration in Albino wistar rats was also studied. EPI-NPs showed marked reduction in tumor size $40% while tumor size was increased 3.55 and 3.28 folds in control as well as in group treated orally with free epirubicin solution (EPI-S), respectively. Furthermore, toxicological evaluation demonstrated insignificant difference in levels of biomarkers including MDA, CAT, SOD, LDH, CK-MB, AST and ALT when EPI-NPs-oral treatment was compared with control group while levels of these biomarkers were found extremely significant in group treated with EPI-S (i.v). and demonstrated increment in LDH (p50.001), CK-MB (p50.001), AST (p50.001), ALT (p50.001) and MDA levels (p50.001) and reduction in SOD (p50.001) and CAT levels (p50.001) thus confirmed better safety profile of EPI-NPs oral than EPI-S i.v. Biodistribution study demonstrated the presence of NPs in different body organs and blood which suggests probability of NPs translocation across intestine thus at the tumor site.

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Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers

Cited by 94 publications

References 25 publications

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Preparation and characterization of dextran nanobubbles for oxygen delivery

Improved oral efficacy of epirubicin through polymeric nanoparticles: pharmacodynamic and toxicological investigations

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