Preparation of hollow magnetic molecularly imprinted polymer and its application in silybin recognition and controlled release

Ji, Kang; Luo, Xiaomei; He, Leqing; Liao, Sen; Hu, Lin; Han, Jingwen; Chen, Can; Liu, Yaqing; Tan, Nguan Soon

doi:10.1016/j.jpba.2019.113036

Cited by 31 publications

(15 citation statements)

References 28 publications

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“…Then the increase rate slowed down from 60 min to 180 min, and the adsorption reached equilibrium at 180 min. Compared with the adsorption equilibrium times of the relevant hollow magnetic silybin molecular imprinted polymers without liquid crystal ingredient (240 min) [24] and the classical solid imprinted materials (7 h), [31] HMS@LC-MIP presented a shorter time, which was greatly probably because of the low cross-linker degree of the combined liquid crystal matrix in HSM@LC-MIP. Therefore, HMS@LC-MIP adsorbing silybin was a rapid process, and it possessed some advantages of the faster mass transfer rate and the better combined dynamics.…”

Section: Adsorption Kineticsmentioning

confidence: 93%

“…[21,22,23] In consideration of the statements above, in order to obtain excellent silybin sustained release agent with high capacity and good oral bioavailability, in this study, we prepared the hollow magnetic silybin liquid crystal imprinted polymer (HMS@LC-MIP) through the reverse atom radical transfer (RATRP) technology on basis of our former research. [24] The aim product possessed better physical properties and superior adsorption efficiency than the former. The structure and morphology of the eventual imprinted materials were characterized by Fourier transform infrared spectroscopy (FT-IR), thermo-gravimetric analysis (TGA), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) and other tests.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Properties of Hollow Magnetic Liquid Crystal Molecularly Imprinted Polymers as Silybin Sustained‐release Carriers

Tan

Chen

et al. 2021

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In this work, a new drug carrier, the hollow magnetic silybin liquid crystal molecular imprinted polymer (HMS@LC-MIP) was prepared through the reverse atom radical transfer polymerization(RATRP) method. In order to decrease the degree of cross-linker, the liquid crystal ingredient methylphenyl dicyclohexyl ethylene, a kind of physical cross-linker, being able to replace the chemical cross-linker partly, was introduced into the synthetic system. The characterizations of HMS@LC-MIPs were investigated by FT-IR, VSM, TEM and so on. A series of adsorption experiments showed the maximum adsorption capacity and the adsorption equilibrium time of HMS@LC-MIP were 18.53 mg g À 1 and 180 min, respectively, and the relative selectivity factor β = 2.06 implied HMS@LC-MIP had the high selectivity to the template. The in-vitro release experiments exhibited HMS@LC-MIP possessed the good responsiveness to pH values and the desirable slow release performance with 48 h of sustaining time. In short, the HMS@LC-MIP should be of a potential as drug sustained-release agent in the future.

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Section: Adsorption Kineticsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Hollow Magnetic Liquid Crystal Molecularly Imprinted Polymers as Silybin Sustained‐release Carriers

Tan

Chen

et al. 2021

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“…Commonly used functional surfaces include amine and vinyl groups 21‐23 . For instance, vinyl groups on an iron oxide surface can be co‐polymerized with vinyl monomers such as methacrylic acid, which is amongst the most popular monomers for MIP synthesis 24,25 . Other materials such as magnetic carbon nanotubes (MCNT) offer electrical conductivity properties and also have been used as a platform for coating MIP polymers 26,27 …”

Section: Magnetic Molecular Imprinted Polymer (Mmip)mentioning

confidence: 99%

Recent developments on magnetic molecular imprinted polymers (MMIPs) for sensing, capturing, and monitoring pharmaceutical and agricultural pollutants

Aylaz

Kuhn

Lau

et al. 2021

J of Chemical Tech & Biotech

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Among the many classes of pollutants, bioactive contaminants including pesticides, herbicides, and other pharmaceutical active compounds (PhACs) are causing significant concern. These chemicals have been linked directly to contamination of freshwater and food sources, threatening water and food security. Contamination from antibiotics, one class of PhACs, is also considered to link strongly to the global problem of antimicrobial resistance (AMR). Pollution from these contaminants has hit developing countries harder as a consequence of less stringent legislation on waste discharge from agricultural industries. Current sampling and monitoring methods [e.g. liquid chromatography mass spectrometry (LC–MS)] are expensive, time‐consuming, immobile and require skilled users. Recent development of devices fitted with molecular imprinted polymers (MIPs) have been found to be particularly attractive owing to their low cost, stability, high selectivity and mobility. MIPs also can be used to extract these organic pollutants at low concentrations. The latest development of magnetic MIPs (MMIPs) further facilitates the separation and recovery of these absorbents by using an external magnetic field after the target molecules have been bound, thus avoiding laborious centrifugation and filtration for separation and recovery. The purpose of this perspective is to summarize the recent development of MMIPs in the past ten years. We will focus on their applications in food industries and the agricultural sector. Several potential developments in combined analytical techniques using MMIPs also will be discussed. As pollution to our environment is now a focal point in human life, new analytical techniques based on MMIPs will be of great interest to the science communities. © 2021 Society of Chemical Industry

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“…Most commonly, the imprinting process is conducted by introducing the template molecule to functional monomer and functional crosslinking agent, before initiating polymerization by the addition of a photo/thermal initiator and the requisite conditions [ [21] , [22] , [23] , [24] ]. The template can then extracted by means of mechanical grinding and solid phase extraction by prolonged washing with protic solvents [ [25] , [26] , [27] ] ( Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

Lowdon

Diliën

Singla

et al. 2020

Sensors and Actuators B: Chemical

183

103

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Highlights The review aims to summarize recent commercially interesting innovations in MIP-based sensor design. In addition to sensors, commercially viable assays based on MIPs are analysed and recent advances are summarized and discussed. The review also analyses how commercial MIP companies could contribute to a next step in the commercialization of MIP-based detection systems. The review contains a critical analysis and discussion on MIP-based sensors and assay commercialization as well as an outlook/recommendation for the future.

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Preparation of hollow magnetic molecularly imprinted polymer and its application in silybin recognition and controlled release

Cited by 31 publications

References 28 publications

Preparation and Properties of Hollow Magnetic Liquid Crystal Molecularly Imprinted Polymers as Silybin Sustained‐release Carriers

Preparation and Properties of Hollow Magnetic Liquid Crystal Molecularly Imprinted Polymers as Silybin Sustained‐release Carriers

Recent developments on magnetic molecular imprinted polymers (MMIPs) for sensing, capturing, and monitoring pharmaceutical and agricultural pollutants

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

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