Preparation of hydrogel microspheres by coacervation of aqueous polyphosphazene solutions

Andrianov, Alexander K.; Chen, Jianping; Payne, Lendon G.

doi:10.1016/s0142-9612(97)00227-5

Cited by 83 publications

(73 citation statements)

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“…The lead compound, poly[di(carboxylatophenoxy)phosphazene], sodium salt (PCPP) has been advanced into clinical trials (22)(23)(24) and PCPP formulated vaccines were reported to be safe and immunogenic in humans (22,23). Most importantly, the macromolecular nature of PCPP ensures excellent film forming and microencapsulating properties (25,26). Biodegradability of this material allows the use of high molecular weight compounds, producing highly viscous solutions, an important feature for any coating process.…”

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confidence: 99%

Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization

Andrianov

DeCollibus

Gillis

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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141

115

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Intradermal immunization using microfabricated needles represents a potentially powerful technology, which can enhance immune responses and provide antigen sparing. Solid vaccine formulations, which can be coated onto microneedle patches suitable for simple administration, can also potentially offer improved shelf-life. However the approach is not fully compatible with many vaccine adjuvants including alum, the most common adjuvant used in the vaccine market globally. Here, we introduce a polyphosphazene immunoadjuvant as a biologically potent and synergistic constituent of microneedle-based intradermal immunization technology. Poly[di-(carboxylatophenoxy)phosphazene], PCPP, functions both as a vaccine adjuvant and as a key microfabrication material. When used as part of an intradermal delivery system for hepatitis B surface antigen, PCPP demonstrates superior activity in pigs compared to intramascular administration and significant antigen sparing potential. It also accelerates the microneedle fabrication process and reduces its dependence on the use of surfactants. In this way, PCPP-coated microneedles may enable effective intradermal vaccination from an adjuvanted patch delivery system. polyphosphazenes ͉ vaccine adjuvants

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mentioning

confidence: 99%

Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization

Andrianov

DeCollibus

Gillis

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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141

115

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“…The water solubility of this hydrophobic polyphosphazene, which contained approximately 60 mol % hydrophobic trifluoroethoxy groups, makes it compatible with previously described aqueous-based protein encapsulation methods. 4 All of the synthesized polymers were soluble in a mixture of 25% (v/v) water and 75% (v/v) ethanol.…”

Section: Studies Of Polymer Solubility and Water Sorptionmentioning

confidence: 99%

“…A water-soluble polymer containing carboxylic acid groups, poly[di(carboxylatophenoxy)phosphazene] (PCPP) has been extensively studied in hydrogel-based microencapsulation systems and controlled release formulations. [4][5][6] Previous studies have also demonstrated that hydrophobic fluorinated polyphosphazenes are interesting as biocompatible materials. 7,8 Specifically, polyphosphazenes containing trifluoroethoxy side groups showed promising results as stent coatings and were capable of significantly reducing the restenosis rates.…”

Section: Introductionmentioning

confidence: 99%

“…1 Polyphosphazenes containing ionic moieties have been investigated as materials for controlled release formulations and multilayer coatings. [2][3][4][5] These polymers show activity in ionic complexation reactions and are capable of forming ionically crosslinked hydrogels under mild conditions. A water-soluble polymer containing carboxylic acid groups, poly[di(carboxylatophenoxy)phosphazene] (PCPP) has been extensively studied in hydrogel-based microencapsulation systems and controlled release formulations.…”

Section: Introductionmentioning

confidence: 99%

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Fluorinated polyphosphazene polyelectrolytes

Andrianov

Marin

Peterson

et al. 2006

J of Applied Polymer Sci

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Polyphosphazene polyelectrolytes containing various amounts of hydrophobic fluorinated moieties and ionic carboxylic acid groups were synthesized. Polymer compositions and molecular weights were characterized by NMR and gel permeation chromatography. Interestingly, poly[(carboxylatophenoxy)(trifluoroethoxy)phosphazene] containing 60 mol % fluorinated groups was found to be soluble in aqueous solutions. The behavior of fluorinated polyelectrolytes in reactions of ionic complexation with multivalent and monovalent salts was studied in aqueous solutions and ethanolwater mixtures. Such reactions led to the formation of ionotropic hydrogels under mild conditions and, thus, are of importance to the development of microencapsulation processes and controlled release formulations. All of the synthesized polymers underwent phase separation in the presence of multivalent ionic crosslinkers, such as spermine and calcium chloride. This included a water-soluble polyelectrolyte containing 40 mol % ionic groups and hydrophobic polymer with only 3 mol % carboxylic acid groups.

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“…The methods commonly used in microsphere preparation include emulsion method 8 , phase separation method 9 , spray drying method 10 , ultrasonic atomization method 11 , electrospray method 12 , and microfluidic method 13 . Among the above-mentioned methods, spray drying method is most widely used in manufacture scale and the emulsion methods are commonly accepted in laboratory level.…”

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2012

IJPSR

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Preparation of hydrogel microspheres by coacervation of aqueous polyphosphazene solutions

Cited by 83 publications

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Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization

Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization

Fluorinated polyphosphazene polyelectrolytes

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