Preparation of hydrogels for atopic dermatitis containing natural herbal extracts by gamma-ray irradiation

Lim, Youn-Mook; An, Sung-Jun; Kim, Hae-Kyoung; Kim, Yun-Hye; Youn, Min-Ho; Gwon, Hui-Jeong; Shin, Junhwa; Nho, Young Chang

doi:10.1016/j.radphyschem.2009.03.074

Cited by 13 publications

(6 citation statements)

References 14 publications

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“…Hydrogel is made up of a three-dimensional (3D) network of hydrophilic polymers. 15 The network confers an insoluble behavior to the polymeric system and allows the hydrogels to absorb from 10–20% (an arbitrary lower limit) to up to thousands of times their equivalent weight in water until the process reaches an equilibrium state. 10,16 They are mainly employed to dry to-moderately draining wounds, to promote autolytic debridement in necrotic wounds and in granulating wounds.…”

Section: Introductionmentioning

confidence: 99%

A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

et al. 2018

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Section: Introductionmentioning

confidence: 99%

A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

et al. 2018

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“…49 Because of the moisturizing effects and the activity of the extracts on atopic wounds, mice treated with the patch have effectively recovered from edema led by contact dermatitis (Figure 2), 49 and have suffered from less itchiness caused by AD. 49 In addition, the patch can be attached to or detached from the skin easily. 49 This makes clinical applications of the patch more viable.…”

Section: Strengths Of Hydrogels For Delivery Of Herbal Medicinesmentioning

confidence: 99%

“…49 In addition, the patch can be attached to or detached from the skin easily. 49 This makes clinical applications of the patch more viable.…”

Section: Strengths Of Hydrogels For Delivery Of Herbal Medicinesmentioning

confidence: 99%

“…With advances in materials design, some hydrogels have also been reported to allow for prolonged and stimuli-controlled drug release. , An overview of the important properties of hydrogels for delivery of herbal medicines is provided in Figure . The possibility of using hydrogels as carriers of herbal medicines has been demonstrated by Lim et al, who have prepared a hydrogel patch containing two herbal extracts for treatment of atopic dermatitis (AD). The first extract is from Ulmus davidiana var.…”

Section: Strengths Of Hydrogels For Delivery Of Herbal Medicinesmentioning

confidence: 99%

“…It has also been reported to have anticancer, antioxidant, and adjuvant activities . A hydrogel patch containing the two extracts has been fabricated by “freezing and thawing” and 60 Co γ-ray irradiation . Because of the moisturizing effects and the activity of the extracts on atopic wounds, mice treated with the patch have effectively recovered from edema led by contact dermatitis (Figure ), and have suffered from less itchiness caused by AD .…”

Section: Strengths Of Hydrogels For Delivery Of Herbal Medicinesmentioning

confidence: 99%

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Hydrogel-Based Materials for Delivery of Herbal Medicines

Lai

Rogach

2017

ACS Appl. Mater. Interfaces

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Herbal medicine, as an integral component of oriental medicine, has assimilated into the lives of Asian people for millennia. The therapeutic efficiency of herbal extracts and ingredients has, however, been limited by various factors, including the lack of targeting capacity and poor bioavailability. Hydrogels are hydrophilic polymer networks that can imbibe a substantial amount of fluids. They are biocompatible, and may enable sustained drug release. Hydrogels, therefore, have attracted widespread studies in pharmaceutical formulation. This article first reviews the latest progress in the development of hydrogel-based materials as carriers of herbal medicines, followed by a discussion of the relationships between hydrogel properties and carrier performance. Finally, the promising potential of using hydrogels to combine medicinal herbs with synthetic drugs in one single treatment will be highlighted as an avenue for future research.

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Hydrogels: A Promising Vehicle for the Topical Management of Atopic Dermatitis

Barbosa

Torres

Lima

2021

Advanced Therapeutics

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Atopic dermatitis (AD) is an inflammatory skin disease with a high worldwide prevalence. AD is characterized by fluctuating and recurrent eczematous lesions and intense itch, being associated with high physical and psychological impact leading to disturbed sleep quality, anxiety, and depression. Most of the patients have mild to moderate forms of atopic dermatitis and topical therapies (emollients, corticosteroids, calcineurin, and phosphodiesterase 4 inhibitors) are the mainstay of therapy for these patients. Hydrogels are explored in the field of cutaneous application and have proven to be a good solution as a topical vehicle for atopic dermatitis, due to their high water content, improved drug delivery, responsiveness to stimuli and versatility in terms of preparation and drug-loading, representing a good alternative to regular ointments or creams. This review highlights some of the atopic dermatitis characteristics and the use of hydrogels in the management of this disease. An outline of hydrogels as drug delivery systems for bioactive compounds is discussed, as well as their major advantages and drawbacks when compared to other galenic forms, and also an overview of clinical trials and patents engaged in the past 20 years.

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Preparation of hydrogels for atopic dermatitis containing natural herbal extracts by gamma-ray irradiation

Cited by 13 publications

References 14 publications

A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

Hydrogel-Based Materials for Delivery of Herbal Medicines

Hydrogels: A Promising Vehicle for the Topical Management of Atopic Dermatitis

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