Preparation of hydroxyapatite via microemulsion route

Koumoulidis, George C.; Katsoulidis, Alexandros P.; Ladavos, Athanasios; Pomonis, P.J.; Trapalis, C.; Sdoukos, Antonios T.; Vaimakis, T.

doi:10.1016/s0021-9797(02)00233-3

Cited by 133 publications

(65 citation statements)

References 22 publications

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“…Additionally, and despite the advances in preparation technology of synthetic Ca/P composites [2,8,9,10], limitations remain in the ability of synthetic bioceramics to duplicate the composition and structure of the mineral component of bone [9,10,11]. In fact, natural hydroxyapatite is non-stoichiometric (exhibits a Ca/P ratio higher than 1.67) and contains carbonate groups and usually some Mg and other ions built into its structure.…”

Section: Introductionmentioning

confidence: 99%

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Effect of the calcination temperature on the composition and microstructure of hydroxyapatite derived from human and animal bone

Figueiredo

Fernando

Martins

et al. 2010

Ceramics International

325

198

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The present work focus the study of cortical bone samples of different origins (human and animal) subjected to different calcination temperatures (600, 900 and 1200 8C) with regard to their chemical and structural properties. For that, not only standard techniques such as thermogravimetric analysis, Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy were used but also mercury intrusion porosimetry. The latter technique was applied to evaluate the effects of the temperature on the microstructure of the calcined samples regarding porosity and pore size distribution.Although marked alterations in structure and mineralogy of the bone samples on heating were detected, these alterations were similar for each specimen. At 600 8C the organic component was removed and a carbonate apatite was obtained. At 900 8C, carbonate was no longer detected and traces of CaO were found at 1200 8C. Crystallinity degree and crystallite size progressively increased with the calcination temperature, contrary to porosity that strongly decreased at elevated temperatures. In fact, relatively to the control samples, a significant increase in porosity was found in samples calcined at 600 8C (reaching values around 50%). At higher temperatures, a dramatic decrease was observed, reaching, at 1200 8C, values comparable to those of the non-calcined bone. #

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Section: Introductionmentioning

confidence: 99%

“…Although the presence of these ions is very low, they play a vital role in the biological reactions associated with bone metabolism [5,12]. It has been shown that carbonate incorporation tends to decrease the crystallinity and to augment the solubility of hydroxyapatite, enhancing its biodegradation rate [4,5,10,11].…”

Section: Introductionmentioning

confidence: 99%

Effect of the calcination temperature on the composition and microstructure of hydroxyapatite derived from human and animal bone

Figueiredo

Fernando

Martins

et al. 2010

Ceramics International

325

198

View full text Add to dashboard Cite

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“…A decrease in the frequency shift was observed during repeated testing [33]. Ionic surfactants, such as SDS, have been considered as candidates for removing chemicals adsorbed on bioceramics because of their strong exchange reactions; however, these surfactants were easily adsorbed on HAp [34][35][36][37]. Effective removal methods for HAp that do not damage or change the surface properties and retain the reusability of HAp sensors are still to be developed.…”

Section: Introductionmentioning

confidence: 99%

Reusable hydroxyapatite nanocrystal sensors for protein adsorption

Tagaya

Ikoma

Hanagata

et al. 2010

Science and Technology of Advanced Materials

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The repeatability of the adsorption and removal of fibrinogen and fetal bovine serum on hydroxyapatite (HAp) nanocrystal sensors was investigated by Fourier transform infrared (FTIR) spectroscopy and quartz crystal microbalance with dissipation (QCM-D) monitoring technique. The HAp nanocrystals were coated on a gold-coated quartz sensor by electrophoretic deposition. Proteins adsorbed on the HAp sensors were removed by (i) ammonia/hydrogen peroxide mixture (APM), (ii) ultraviolet light (UV), (iii) UV/APM, (iv) APM/UV and (v) sodium dodecyl sulfate (SDS) treatments. FTIR spectra of the reused surfaces revealed that the APM and SDS treatments left peptide fragments or the proteins adsorbed on the surfaces, whereas the other methods successfully removed the proteins. The QCM-D measurements indicated that in the removal treatments, fibrinogen was slowly adsorbed in the first cycle because of the change in surface wettability revealed by contact angle measurements. The SDS treatment was not effective in removing proteins. The APM or UV treatment decreased the frequency shifts for the reused HAp sensors. The UV/APM treatment did not induce the frequency shifts but decreased the dissipation shifts. Therefore, we conclude that the APM/UV treatment is the most useful method for reproducing protein adsorption behavior on HAp sensors.

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“…Therefore, different production methods were reported such as mechanochemistry [3,4], ultrasonic irradiation [5], microwave irradiation [6,7], sol-gel [8][9][10][11], chemical precipitation [12,13], hydrothermal method [14][15][16], hydrolysis [17], microemulsion [18][19][20], and emulsion liquid membrane [21]. The synthesized HAp does not have adequate biological properties as the natural apatite existing in bones.…”

Section: Introductionmentioning

confidence: 99%