Preparation of ibuprofen-loaded chitosan films for oral mucosal drug delivery using supercritical solution impregnation

Tang, Chuan; Guan, Yong; Yao, Shan‐Jing; Zhu, Zhen

doi:10.1016/j.ijpharm.2014.07.039

Cited by 87 publications

(41 citation statements)

References 41 publications

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“…Among these materials, chitosan has been highly utilized in a number of oral drug delivery systems, including chitosan-based micro- and nanoparticulate drug delivery systems [89–94], chitosan-drug conjugates [95, 96], and chitosan macroscale patches [97, 98]. Chitosan is an attractive material for micro/nanofabricated platforms as it is compatible with a number of microfabrication approaches [99, 100], is stable through pH values relevant to GI physiology [101], and has been utilized in microfabricated oral drug delivery systems [58, 102].…”

Section: Strategies To Increase Micro/nanofabricated Oral Drug Delmentioning

confidence: 99%

Micro/nanofabricated platforms for oral drug delivery

Fox

Kim

et al. 2015

Journal of Controlled Release

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The oral route of drug administration is most preferred due to its ease of use, low cost, and high patient compliance. However, the oral uptake of many small molecule drugs and biotherapeutics is limited by various physiological barriers, and, as a result, drugs suffer from issues with low solubility, low permeability, and degradation following oral administration. The flexibility of micro- and nanofabrication techniques has been used to create drug delivery platforms designed to address these barriers to oral drug uptake. Specifically, micro/nanofabricated devices have been designed with planar, asymmetric geometries to promote device adhesion and unidirectional drug release toward epithelial tissue, thereby prolonging drug exposure and increasing drug permeation. Furthermore, surface functionalization, nanotopography, responsive drug release, motion-based responses, and permeation enhancers have been incorporated into such platforms to further enhance drug uptake. This review will outline the application of micro/nanotechnology to specifically address the physiological barriers to oral drug delivery and highlight technologies that may be incorporated into these oral drug delivery systems to further enhance drug uptake.

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Section: Strategies To Increase Micro/nanofabricated Oral Drug Delmentioning

confidence: 99%

Micro/nanofabricated platforms for oral drug delivery

Fox

Kim

et al. 2015

Journal of Controlled Release

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“…At predetermined intervals (15,30,45,60,75,90,105,120,150,180,210, 240 min and 24 hours), the films were removed, the excess water was dried with filter paper and weighed.…”

Section: Swelling and Erosionmentioning

confidence: 99%

Preparation, Characterization and Evaluation of Antifungal Efficacy of Chitosan/Soy Phosphatidylcholine Topical Films Containing Griseofulvin

Bavarsad

Kouchak

Varmaziar

et al. 2015

Jundishapur J Nat Pharm Prod

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Background:Griseofulvin is an antifungal drug and is available as oral dosage forms. Development of topical treatment could be advantageous for superficial fungal infections of skin. The film forming property of chitosan has made it interesting for transdermal/ dermal drug delivery, but showed lack of stability. Soy phosphatidylcholine (PC), besides playing penetration enhancer and solubilizer roles, could enhance the stability and mechanical properties of the film. Films prepared from a mixture of chitosan and PC can achieve the benefits of both materials. Objectives: The aim of this study was to prepare and characterize films formed from blends of chitosan and soy PC for topical delivery of griseofulvin. Materials and Methods: Topical films composed of chitosan and soy PC were prepared by means of casting and solvent evaporation technique. The properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior and antifungal efficacy against Microsporum gypseum and Epidermophyton floccosum. Results: Presence of soy PC improved mechanical properties, lowered swelling ratio and increased stability of the films. Solubilizing activity of phospholipid resulted in higher flux of drug release from formulation containing higher amount of soy PC. Antifungal efficacy of formulations was confirmed against two species of dermatophytes in vitro. Conclusions: This topical composite film had the potential for griseofulvin delivery to superficial fungal infections.

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“…To improve oromucosal delivery of NSAIDs, several new dosage forms have been developed, such as mucoadhesive films, 8,9 proniosomal gel, 10 liquid crystalline film, 11 buccal tablet, 12 electrospun nanofibers (NFs) 13 and many others. Among these drug delivery systems, electrospun NFs have attracted increasing attention in the recent years as novel carrier systems.…”

Section: Introductionmentioning

confidence: 99%