Preparation of low-molecular-weight chitosan derivative zinc complexes and their effect on the growth of liver cancer cells in vitro

Wang, Rong‐Min; He, Naipu; Song, Pengfei; He, Yufeng; Ding, Lei; Lei, Ziqiang

doi:10.1351/pac-con-08-11-15

Cited by 28 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the excellent candidate as a support for catalysts is chitosan, it is produced from a key constituent of the exoskeletons of crustaceans . Chitosan has been exhibited biopesticidal, antifungal and anticancer properties and can be used as absorbents for metals in medicine and drug delivery …”

Section: Introductionmentioning

confidence: 99%

Pd nanoparticles immobilized on magnetic chitosan as a novel reusable catalyst for green Heck and Suzuki cross‐coupling reaction: In water at room temperature

Hajipour

Sadeghi

Khorsandi

2017

Applied Organom Chemis

View full text Add to dashboard Cite

A novel type of magnetically responsive chitosan nanocomposite was successfully synthesized as a green and high powerful palladium‐based heterogeneous catalyst and its efficiency in Heck and Suzuki cross‐coupling was evaluated. This catalyst promote a large library of functional substrates of these reactions under mild and sustainable conditions (water or ethanol as solvent, at room temperature, in significantly short reaction time (20 minutes)) and stand as recyclable, metal scavenging catalytic systems.

show abstract

Section: Introductionmentioning

confidence: 99%

Pd nanoparticles immobilized on magnetic chitosan as a novel reusable catalyst for green Heck and Suzuki cross‐coupling reaction: In water at room temperature

Hajipour

Sadeghi

Khorsandi

2017

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…), anticancer (Wang et al . ), antioxidant (Kim and Tomas ), anticholesteremic (Yao et al . ) and hypolipidemic (Yao et al .…”

Section: Introductionmentioning

confidence: 99%

“…Especially for degree of polymerization (DP) 6–8 chitooligosaccharides, the excellent physiochemical properties make it possess the potential antitumor activity (Wang et al . ; Zhang et al . ).…”

Section: Introductionmentioning

confidence: 99%

Key Technologies of Enzymatic Preparation for DP 6–8 Chitooligosaccharides

Dong

Wang

Zhao

et al. 2014

J Food Process Engineering

View full text Add to dashboard Cite

Degree of polymerization (DP) 6–8 chitooligosaccharides are edible hydrolyzates from chitosan and possess excellent bioactivities, especially for a potential antitumor ingredient. The objective of this study was to develop a promising enzymatic attempt for DP 6–8 chitooligosaccharides preparation. Chitosan (2%, w/v) was dissolved in acetic acid. Sequentially, six types of nonspecific enzymes were used to compare chitosanolytic activities under the optimum conditions. Results indicated that cellulase was most capable of hydrolysis, whereas others were slightly acted. The phenomenon resulted from the glycosidic bonds that existed in the chitosan. Based on preliminary experiments, cellulase and chitosanase were combined employing to digest chitosan. The enzyme mixture promoted the hydrolysis degree and the yield of resulting chitooligosaccharides were measured through high‐performance liquid chromatography. Data showed that the highest yield of DP 6–8 chitooligosaccharides reached to 79.8% w/w by hybrid enzymes adding simultaneously at pH 5.3 and 45°C after 6 h. Practical Applications Chitooligosaccharides are widely used in the pharmaceutical, food industry and agricultural field because of its excellent and specific bioactivities, depending on the degrees of polymerization (DPs) of chitooligosaccharides. For instance, chitooligosaccharides with DP 6–8 have potential antitumor activity that could be used as ingredients for pharmaceutical drugs, health‐care food and formula products. Another very important potential application of chitooligosaccharides with DP 6–8 is as a potent plants elicitor that could be an environment‐friendly biological stress‐resistant agent to replace chemical reagents in the agricultural field. Hence, the study of preparation methods of chitooligosaccharides with DP 6–8 is important and valuable.

show abstract

“…Investigation of water soluble and insoluble complexes of polymer with protein in the presence of metal ions has important applications in various areas [1][2][3][4][5][6][7][8][9][10][11][12][13][14] . In recent studies, it has been shown that metal (M) ions (Cu 2+ , Zn 2+ , Fe 2+ ) which are complexed with functional polymers have an important role in biological processes 2, [15][16][17][18][19][20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

The Formation of Polycomplexes of Poly(Methyl Vinyl Ether-Co-Maleic Anhydride) and Bovine Serum Albumin in the Presence of Copper Ions

Karahan

Mustafaeva

Özeroğlu

2014

Polish Journal of Chemical Technology

View full text Add to dashboard Cite

The binary and ternary complex formations of poly(methyl vinyl ether-co-maleic anhydride) (PMVEMA) with copper ions and with bovine serum albumin (BSA) in the presence of copper ions in phosphate buffer solution at pH = 7 were examined by the techniques of UV-visible, fl uorescence, dynamic light scattering, atomic force microscopy measurements. In the formation of binary complexes of PMVEMA-Cu(II), the addition of copper ions to the solution of PMVEMA in phosphate buffer solution at pH = 7 forms homogeneous solutions when the molar ratio of Cu(II)/MVEMA is 0.5. Then the formations of ternary complexes of PMVEMA-Cu(II)-BSA were examined. Study analysis revealed that the toxicities of polymer-metal and polymer-metal-protein mixture solutions depend on the nature and ratio of components in mixtures.

show abstract

Preparation of low-molecular-weight chitosan derivative zinc complexes and their effect on the growth of liver cancer cells in vitro

Cited by 28 publications

References 41 publications

Pd nanoparticles immobilized on magnetic chitosan as a novel reusable catalyst for green Heck and Suzuki cross‐coupling reaction: In water at room temperature

Pd nanoparticles immobilized on magnetic chitosan as a novel reusable catalyst for green Heck and Suzuki cross‐coupling reaction: In water at room temperature

Key Technologies of Enzymatic Preparation for DP 6–8 Chitooligosaccharides

The Formation of Polycomplexes of Poly(Methyl Vinyl Ether-Co-Maleic Anhydride) and Bovine Serum Albumin in the Presence of Copper Ions

Contact Info

Product

Resources

About