Preparation of magnetic nanoparticle-cholesterol imprinted polymer using semi-covalent imprinting approach for ultra-effective and highly selective cholesterol adsorption

Effting, Luciane; Prete, Maiyara Carolyne; Urbano, Alexandre; Effting, Leticia Maria; Cano, M. E.; Bail, Alesandro; Tarley, César Ricardo Teixeira

doi:10.1016/j.reactfunctpolym.2022.105178

Cited by 15 publications

(11 citation statements)

References 69 publications

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“…The first weight loss at 5–160 °C was attributable to the physically adsorbed water and the breakdown of components with a low heat stability for all materials. FNC@MIPs exhibited considerable weight loss in the 160–650 °C range, which may be attributed to two factors: one, the phase shift of ferric tetroxide or the thermal breakdown of amines, 27 and two, the disintegration of the imprinted layer under the high-temperature conditions. At temperatures higher than 650 °C, the weight of Fe 3 O 4 @NH 2 was much greater than that of FNC@MIPs, indicating the presence of an imprinted layer.…”

Section: Resultsmentioning

confidence: 99%

A boronate-affinity magnetic molecularly imprinted polymer for luteolin recognition

et al. 2023

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Section: Resultsmentioning

confidence: 99%

A boronate-affinity magnetic molecularly imprinted polymer for luteolin recognition

et al. 2023

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“…The homogeneous population of binding sites towards ractopamine in the covalently produced MIP was confirmed by isotherm equilibrium-binding experiments [9], providing a substantial difference between it and the heterogeneous population of binding sites observed in the non-covalently formed MIP [10]. More recently, the covalent approach was used to synthesize more advanced and selective materials integrated with metal-organic frameworks [11], magnetic cores [12], surfaces of microtiter plates [13], or dendritic fibrous silica [14].…”

Section: Introductionmentioning

confidence: 89%

N-(2-Arylethyl)-2-methylprop-2-enamides as Versatile Reagents for Synthesis of Molecularly Imprinted Polymers

2022

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The paper describes the formation of six aromatic N-(2-arylethyl)-2-methylprop-2-enamides with various substituents in benzene ring, viz., 4-F, 4-Cl, 2,4-Cl2, 4-Br, 4-OMe, and 3,4-(OMe)2 from 2-arylethylamines and methacryloyl chloride in ethylene dichloride with high yields (46–94%). The structure of the compounds was confirmed by 1H NMR, 13C NMR, IR, and HR-MS. Those compounds were obtained to serve as functionalized templates for the fabrication of molecularly imprinted polymers followed by the hydrolysis of an amide linkage. In an exemplary experiment, the imprinted polymer was produced from N-(2-(4-bromophenyl)ethyl)-2-methylprop-2-enamide and divinylbenzene, acting as cross-linker. The hydrolysis of 2-(4-bromophenyl)ethyl residue proceeded and the characterization of material including SEM, EDS, 13C CP MAS NMR, and BET on various steps of preparation was carried out. The adsorption studies proved that there was a high affinity towards the target biomolecules tyramine and L-norepinephrine, with imprinting factors equal to 2.47 and 2.50, respectively, when compared to non-imprinted polymer synthesized from methacrylic acid and divinylbenzene only.

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“…The covalent attachment of the template to siloxane-based monomers is occasionally utilized to form molecularly imprinted siloxane polymers. In a unique recent paper, Effting and co-workers [ 185 ] created a “sacrificial spacer” for the non-covalent adsorption of the target molecule cholesterol. The strategy involved the formation of a siloxane layer composed of tetraethoxysilane and cholesterol-functionalized siloxane compound that was obtained by the reaction between 3-(triethoxysilyl)propyl isocyanate and hydroxy group in position 3 of sterol system, enabling the formation of the amide bond.…”

Section: Molecularly Imprinted Siloxane Layersmentioning

confidence: 99%

A Fusion of Molecular Imprinting Technology and Siloxane Chemistry: A Way to Advanced Hybrid Nanomaterials

2023

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Molecular imprinting technology is a well-known strategy to synthesize materials with a predetermined specificity. For fifty years, the “classical” approach assumed the creation of “memory sites” in the organic polymer matrix by a template molecule that interacts with the functional monomer prior to the polymerization and template removal. However, the phenomenon of a material’s “memory” provided by the “footprint” of the chemical entity was first observed on silica-based materials nearly a century ago. Through the years, molecular imprinting technology has attracted the attention of many scientists. Different forms of molecularly imprinted materials, even on the nanoscale, were elaborated, predominantly using organic polymers to induce the “memory”. This field has expanded quickly in recent years, providing versatile tools for the separation or detection of numerous chemical compounds or even macromolecules. In this review, we would like to emphasize the role of the molecular imprinting process in the formation of highly specific siloxane-based nanomaterials. The distinct chemistry of siloxanes provides an opportunity for the facile functionalization of the surfaces of nanomaterials, enabling us to introduce additional properties and providing a way for vast applications such as detectors or separators. It also allows for catalyzing chemical reactions providing microreactors to facilitate organic synthesis. Finally, it determines the properties of siloxanes such as biocompatibility, which opens the way to applications in drug delivery and nanomedicine. Thus, a brief outlook on the chemistry of siloxanes prior to the discussion of the current state of the art of siloxane-based imprinted nanomaterials will be provided. Those aspects will be presented in the context of practical applications in various areas of chemistry and medicine. Finally, a brief outlook of future perspectives for the field will be pointed out.

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Preparation of magnetic nanoparticle-cholesterol imprinted polymer using semi-covalent imprinting approach for ultra-effective and highly selective cholesterol adsorption

Cited by 15 publications

References 69 publications

A boronate-affinity magnetic molecularly imprinted polymer for luteolin recognition

A boronate-affinity magnetic molecularly imprinted polymer for luteolin recognition

N-(2-Arylethyl)-2-methylprop-2-enamides as Versatile Reagents for Synthesis of Molecularly Imprinted Polymers

A Fusion of Molecular Imprinting Technology and Siloxane Chemistry: A Way to Advanced Hybrid Nanomaterials

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