Preparation of Montmorillonite-pH-Sensitive Positive Charges Nanocomposites as a Drug Delivery System

Clay-biosurfactant materials as functional drug delivery systems: Slowing down effect in the in vitro release of cinnamic acid

“…HCl 0.1 M (pH = 1.0) and phosphate buffer (pH = 6.8) at 37.0°C. These conditions are widely used to reproduce the oral drug administration and the subsequent physiological release (Calabrese et al, 2013a;Hariyadi et al, 2012;Mahkam and A.L., 2015).…”

Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems

“…The anionic drug was successfully loaded into the interlayer by intercalating cationic monomers into the interlayer of the clay prior to adsorption of drug molecules (Fig. 5) (Mahkam et al 2015). In this study, an intercalated anionic drug (i.e., naproxen) showed an increased release rate under a high pH condition because of the electrostatic repulsive forces from deprotonated COOgroups.…”

“…Even after incorporating montmorillonite, an alginate-based formulation shows more rapid drug release in a neutral condition than that in an acidic condition (Oh et al 2009;Jeong and Jung 2013;Liu et al 2013) because the protonated carboxyl group of alginate maintains intermolecular hydrogen bonds under low pH (Jeong and Jung 2013). However, the negatively charged carboxyl group loses a hydrogen bond in neutral pH and is affected by the intermolecular repulsive force (Mahkam et al 2015). This phenomenon induces swelling and disintegration of the alginate formulation, which cause rapid drug release.…”

A novel 1,2,3-benzotriazolium based ionic liquid monomer for preparation of MMT/poly ionic liquid (PIL) pH-sensitive positive charge nanocomposites

“…Ionic liquids (ILs) are known as the salts with low melting points typically below 100 • C. Recently, many studies have been done on the use of ILs in the pharmaceutical industry, including (1) as prodrug ILs, 16 (2) as a solvent for synthesis and purification of pharmaceutical compounds 17,18 and for dissolving poorly soluble drug molecules, 19 and (3) DDSs. 8,20 ILs are extensively used in the modification of clay nanoparticles for preparation of organic-inorganic polymer nanocomposites, which have both inorganic and organic ingredient properties in a single material. 21 In most of the researches, IL monomers were intercalated into MMT.…”

“…The pH-sensitive polymers deliver drugs into cells by the environmental pH changes. 3 A large number of drug delivery systems (DDSs) containing polymers, such as hydrogels, 4,5 liposome, 6,7 and MMT/polymer nanocomposites 8,9 have been studied during recent years.…”