Preparation of multifunctional Janus nanoparticles on the basis of SPIONs as targeted drug delivery system

Shaghaghi, Behrad; Khoee, Sepideh; Bonakdar, Shahin

doi:10.1016/j.ijpharm.2019.01.020

Cited by 56 publications

(34 citation statements)

References 34 publications

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“…Several studies have recently evaluated magnetic NPs loaded with different drugs (5,6). For example, Cicha et al 7evaluated mitoxantrone-carrying SPIONs and the drug released from SPIONs.…”

Section: In Targeted Therapy the Development Of Magneticallymentioning

confidence: 99%

Synthesis and Investigation of the Curcumin-Loaded Magnetic Lipid Nanoparticles and Their Cytotoxicity Assessment on Human Breast Carcinoma Cell Line

Karami

Rostamizadeh

Shademani

et al. 2020

Jundishapur J Nat Pharm Prod

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Chemotherapy fails to eradicate cancer cells, mainly due to the lack of selective drug accumulation into the tumor site, which can affect healthy cells, as well. In this research, we studied the magnetite nanostructured lipid carriers (NLCs) for targeted delivery of curcumin into breast cancer cells. Superparamagnetic iron oxide nanoparticles (SPIONs) were prepared using coprecipitation method by mixing FeCl2 and FeCl3 in a suitable ratio in alkaline media. The resultant ferrofluid was very stable and possessed high magnetic properties. To prepare SPIONs containing NLCs (NLC-SPIONs), cetyl palmitate and cod-liver oil, Tween 80 and span60 were used as solid lipid, liquid lipid, surfactant, and co-surfactant, respectively. Curcumin as an anticancer drug was loaded into NLC-SPIONs (CUR-NLC-SPIONs) and its characteristics, including particle size, zeta potential, polydispersity index (PDI), drug entrapment efficacy, drug-loading capacity, and thermal stability were evaluated. The results showed that CUR-NLC-SPIONs had a mean particle size of 166.7 ± 14.20 nm, mean zeta potential of-27.6 ± 3.83 mv, and PDI of 0.24 ± 0.14. Encapsulation efficiency for all prepared nanoparticles (NPs) was 99.95 ± 0.015% and drug-loading capacity was 3.76 ± 0.005%. Morphological studies were carried out by transmission electron microscopy (TEM) indicating spherical morphology of the NPs. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay measurements on cell viability proved that the synthesized CUR-NLC-SPIONs possess a better cytotoxic activity against human breast cancer cells compared with free curcumin. This new drug delivery system, which benefits from superparamagnetic properties may serve as a suitable platform for developing new biocompatible drug carriers and with a potential to use in targeted cancer therapy.

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“…Several studies have recently evaluated magnetic NPs loaded with different drugs (5,6). For example, Cicha et al 7evaluated mitoxantrone-carrying SPIONs and the drug released from SPIONs.…”

Section: In Targeted Therapy the Development Of Magneticallymentioning

confidence: 99%

Synthesis and Investigation of the Curcumin-Loaded Magnetic Lipid Nanoparticles and Their Cytotoxicity Assessment on Human Breast Carcinoma Cell Line

Karami

Rostamizadeh

Shademani

et al. 2020

Jundishapur J Nat Pharm Prod

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“…reacted with PEG-Fe3O4-PMMA-MA through the condensation among the carboxyl groups in PMMA-MA and the hydroxyls in CD to obtain the functionalized amphiphilic Janus PEG-Fe3O4-PMMA-MA (CD), which were also named as Fe3O4@AJNPs. Pickering emulsion was employed recently by Shaghaghi et al [26] for the preparation of various types of Janus superparamagnetic iron oxide nanoparticles (SPIONs) decorated with folic acid (FA) and doxorubicin (DOX) with the aim of accumulating target cancerous cells through the FA ligands and deliver chemotherapy drugs. SPIONs were firstly masked and immobilized in paraffin wax particles for the subsequent synthesis of drug-conjugated Janus NPs ( Figure 2).…”

Section: Synthesis Of Magnetic Janus Particlesmentioning

confidence: 99%

“…The preparation of DOX-PCL-SPION (PCL = poly(ε-caprolactone)) involved grafting of DOX-PCL-yne to the particle via azid-yne click reaction in the presence of N,N,N′,N″,N″-pentamethyl diethylene-triamine (PMDETA). Pickering emulsion was employed recently by Shaghaghi et al [26] for the preparation of various types of Janus superparamagnetic iron oxide nanoparticles (SPIONs) decorated with folic acid (FA) and doxorubicin (DOX) with the aim of accumulating target cancerous cells through the FA ligands and deliver chemotherapy drugs. SPIONs were firstly masked and immobilized in paraffin wax particles for the subsequent synthesis of drug-conjugated Janus NPs ( Figure 2).…”

Section: Synthesis Of Magnetic Janus Particlesmentioning

confidence: 99%

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Magnetic Janus Particles for Static and Dynamic (Bio)Sensing

et al. 2019

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Magnetic Janus particles bring together the ability of Janus particles to perform two different functions at the same time in a single particle with magnetic properties enabling their remote manipulation, which allows headed movement and orientation. This article reviews the preparation procedures and applications in the (bio)sensing field of static and self-propelled magnetic Janus particles. The main progress in the fabrication procedures and the applicability of these particles are critically discussed, also giving some clues on challenges to be dealt with and future prospects. The promising characteristics of magnetic Janus particles in the (bio)sensing field, providing increased kinetics and sensitivity and decreased times of analysis derived from the use of external magnetic fields in their manipulation, allows foreseeing their great and exciting potential in the medical and environmental remediation fields.

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“…In nanomedicine, polymeric Janus NPs are very interesting because of their specific features to produce multifunction nanomedicines which have various functional ligands with various chemical and physical features (Xia, Ding, & Ma, 2017; Xie, She, Wang, Sharma, & Smith, 2012). This expands the potential as cancer targeting, diagnosis, and therapeutic beyond what is possible for simple isotropic NPs, and it has been demonstrated that Janus NPs can have more in vitro anticancer effects when compared to simple NPs (Shaghaghi, Khoee, & Bonakdar, 2019).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of combinatorial Janus nanoparticles based on EpCAM‐PEG/PCL for targeted therapy of human colorectal adenocarcinoma

Khezrian

Khoee

Caceres

2020

J Biomedical Materials Res

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Active targeted nanotechnology‐based drug delivery systems have gained significant favor because they have the ability to decrease side effects, improve drug bioavailability, and the potency of anticancer treatment. In this study, functional amphiphilic Janus nanoparticles (JNPs), consisting of hydrophilic and hydrophobic biocompatible polymers as two distinct sides, have been prepared via a robust and simple synthesis method. The surface‐active hydrophilic side of this Janus platform is functionalized with an aptamer against epithelial cell adhesion molecule (EpCAM) to deliver Doxorubicin (DOX) for the treatment of metastasis colorectal adenocarcinoma HT29 cells. The Janus morphology of the nanoparticles and their cell penetration behavior are shown in microscopic evaluations. By evaluating the prepared DOX‐loaded aptamer–modified JNPs by cell‐toxicity assay and confocal microscopy, it was determined that the utilization of an internalization strategy to enhance cell uptake would increase the anticancer effect of the Janus nanocarrier and improve the capacity to deliver the chemotherapeutical drug site‐specifically.

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Preparation of multifunctional Janus nanoparticles on the basis of SPIONs as targeted drug delivery system

Cited by 56 publications

References 34 publications

Synthesis and Investigation of the Curcumin-Loaded Magnetic Lipid Nanoparticles and Their Cytotoxicity Assessment on Human Breast Carcinoma Cell Line

Synthesis and Investigation of the Curcumin-Loaded Magnetic Lipid Nanoparticles and Their Cytotoxicity Assessment on Human Breast Carcinoma Cell Line

Magnetic Janus Particles for Static and Dynamic (Bio)Sensing

Synthesis of combinatorial Janus nanoparticles based on EpCAM‐PEG/PCL for targeted therapy of human colorectal adenocarcinoma

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