Preparation of Nanoemulsions and Solid Lipid Nanoparticles by Premix Membrane Emulsification

Joseph, Sonja; Bunjes, Heike

doi:10.1002/jps.23163

Cited by 56 publications

(36 citation statements)

References 30 publications

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“…The nylon meshes induce an even distribution of the formulation over the membrane. In the EmulsiFlex-C5 and the ISSE, the flow of the emulsion during preparation is in one direction through the membrane whereas during the processing with the LiposoFast, the flow of the emulsion is back and forth between the two syringes (for details see, e.g., [17]). …”

Section: Comparison With Commercial Extrudersmentioning

confidence: 99%

“…A general drawback of membrane emulsification is the risk of membrane fouling (interaction, e. g., attachment, of formulation compounds with the membrane) [12]. Most studies performed so far investigated premix-ME for the production of emulsions with particle sizes in the micrometer range [13][14][15], whereas there are only few investigations about the production of nanoemulsions with premix-ME [16,17]. The size of the resulting particles is mainly controlled by the pore size of the membrane and the number of extrusion cycles.…”

Section: Introductionmentioning

confidence: 99%

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Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification

Gehrmann

Bunjes

2016

Chemical Engineering Journal

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Section: Comparison With Commercial Extrudersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification

Gehrmann

Bunjes

2016

Chemical Engineering Journal

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“…26,30 A typical surfactant, PVA, was used to investigate the effects of surfactant concentrations in the aqueous phase. The results are shown in Table 1.…”

Section: Effects Of Surfactant Quantity and Typementioning

confidence: 99%

“…It is obvious that smaller nanoparticles were obtained with decreased membrane-pore sizes. 30,34 Exceedingly small pore size of 0.5 µm increased the duration of time to produce a similar amount of nanoparticles. On the other hand, a very large pore size caused larger and nonuniform particles.…”

Section: Effects Of Membrane Porementioning

confidence: 99%

Antitumor activity of docetaxel-loaded polymeric nanoparticles fabricated by Shirasu porous glass membrane-emulsification technique

Yu¹,

Tan²,

Zhao³

et al. 2013

IJN

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Docetaxel (DTX) has excellent efficiency against a wide spectrum of cancers. However, the current clinical formulation has limited its usage, as it causes some severe side effects. Various polymeric nanoparticles have thus been developed as alternative formulations of DTX, but they have been mostly fabricated on a laboratory scale. Previously, we synthesized a novel copolymer, poly(lactide)-d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS), and found that it exhibited great potential in drug delivery with improved properties. In this study, we applied the Shirasu porous glass (SPG) membrane-emulsification technique to prepare the DTX-loaded PLA-TPGS nanoparticles on a pilot scale. The effect of several formulation variables on the DTX-loaded nanoparticle properties, including particle size, zeta potential, and drug-encapsulation efficiency, were investigated based on surfactant type and concentration in the aqueous phase, organic/aqueous phase volumetric ratio, membrane-pore size, transmembrane cycles, and operation pressure. The DTX-loaded nanoparticles were obtained with sizes of 306.8 ± 5.5 nm and 334.1 ± 2.7 nm (mean value ± standard deviation), and drugencapsulation efficiency of 81.8% ± 4.5% and 64.5% ± 2.7% for PLA-TPGS and poly(lacticco-glycolic acid) (PLGA) nanoparticles, respectively. In vivo pharmacokinetic study exhibited a significant advantage of PLA-TPGS nanoparticles over PLGA nanoparticles and Taxotere. Drug-loaded PLA-TPGS nanoparticles exhibited 1.78-, 6.34-and 3.35-fold higher values for area under the curve, half-life, and mean residence time, respectively, compared with those of PLGA nanoparticles, and 2.23-, 13.2-, 8.51-fold higher than those of Taxotere, respectively. In vivo real-time distribution of nanoparticles was measured on tumor-bearing mice by near-infrared fluorescence imaging, which demonstrated that the PLA-TPGS nanoparticles achieved much higher concentration and longer retention in tumors than PLGA nanoparticles after intravenous injection. This is consistent with the pharmacokinetic behavior of the nanoparticles. The tumorinhibitory effect of DTX-loaded nanoparticles was observed in vivo in an H22 tumor-bearing mice model via intravenous administration. This indicated that PLA-TPGS nanoparticles are a feasible drug-delivery formulation with a pilot fabrication technique and have superior pharmacokinetic and anticancer effects compared to the commercially available Taxotere.

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“…Uniform droplet size and high drug encapsulation efficiency have been obtained by permeating a dispersed phase into a continuous phase through an SPG membrane at an adequate pressure [10][11][12][13][14]. …”

Section: Research Articlementioning

confidence: 99%

Optimization and Evaluation of Monodispersed Tetrandrine- Loaded PLA Microspheres Prepared With A SPG Membrane Emulsification Technique

Jin¹,

Yin²,

Zhang³

et al. 2017

SOJPPS

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Research articlewidely in vivo without a targeting effect, thus tetrandrine in this formulation does not concentrate highly in diseased organs or tissues [6][7] and usually causes pain or phlebitis. To improve pulmonary drug concentration to maximize its effectiveness and minimize the adverse side effects, tetrandrine polylactic acid microspheres with diameters of 7-15 μm were injected intravenously to achieve lung targeting [8]. This mechanism of lung targeting by injecting more than 7 μm microspheres occurs through mechanical filtration by the pulmonary capillaries, which can damage the lung permanently. Microspheres with diameters between 0.5-5 μm used for pulmonary inhalation could overcome this shortcoming. However, the controllability and uniformity of the microsphere size are closely related to the effects of pulmonary inhalation. The particle size is difficult to control for microspheres prepared by conventional methods, such as emulsification, ultrasonic emulsifying preparation and distribution [9].Recently, a novel method, the Shirasu Porous Glass (SPG) membrane emulsification technique, has been widely applied to the preparation of uniform-sized emulsions. Uniform droplet size and high drug encapsulation efficiency have been obtained by permeating a dispersed phase into a continuous phase through an SPG membrane at an adequate pressure [10][11][12][13][14]. Optimization and Evaluation of Monodispersed AbstractTo improve pulmonary drug concentrations and to maximize the effectiveness and minimize the adverse side effects, uniformsized tetrandrine-loaded polylactide (PLA) microspheres with a suitable particle size for pulmonary inhalation were prepared by the Shirasu Porous Glass (SPG) membrane emulsification technique. The main parameters influencing PLA microsphere properties were investigated: transmembrane pressure, circulation speed, high hydrophilic-lipophilic balance (HLB value), PLA concentration and oil-water volume ratio. Narrowly size-distributed tetrandrine-loaded PLA microspheres were obtained with a high drug encapsulation efficiency of 81.0% and an average diameter of 3.16 μm under optimized conditions. The results of Fourier transform infrared, differential scanning calorimetry and powder X-ray diffraction revealed that tetrandrine would be either molecularly dispersed in the polymer or distributed in an amorphous form. Further, the in vitro drug release experiment confirmed that the uniform-sized tetrandrine-loaded PLA microspheres showed suppressed burst release. These studies provide a basis for the use of uniformly sized 3.16 μm tetrandrine-loaded PLA microspheres for pulmonary inhalation.

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Preparation of Nanoemulsions and Solid Lipid Nanoparticles by Premix Membrane Emulsification

Cited by 56 publications

References 30 publications

Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification

Instrumented small scale extruder to investigate the influence of process parameters during premix membrane emulsification

Antitumor activity of docetaxel-loaded polymeric nanoparticles fabricated by Shirasu porous glass membrane-emulsification technique

Optimization and Evaluation of Monodispersed Tetrandrine- Loaded PLA Microspheres Prepared With A SPG Membrane Emulsification Technique

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