Preparation of naproxen–ethyl cellulose microparticles by spray-drying technique and their application to textile materials

Arici, Mesut; Topbaş, Özlem; Karavana, Sinem Yaprak; Ertan, Gökhan; Sarıışık, Merih; Öztürk, Cihat

doi:10.3109/02652048.2014.913722

Cited by 19 publications

(9 citation statements)

References 53 publications

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“…For formulation with a drug:EC ratio of 1:4, about 10% of a drug was released after 5 min, and about 45% after 30 min. SEM photomicrographs revealed spherical, well-separated particles with a smooth surface and absence of agglomerates [36].…”

Section: Resultsmentioning

confidence: 99%

Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate

et al. 2019

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The taste of drugs is an important factor affecting pharmacotherapy effectiveness, and obtaining formulations with acceptable organoleptic properties is still an ongoing issue in pharmaceutical technology. One of the innovative methods of taste masking is preparation of microparticles by the spray drying technique, utilizing polymers with different physicochemical properties. Rupatadine fumarate (RUP) is one of the newest antihistamines, with an innovative and multidirectional mechanism of action, and an extremely bitter taste. The aim of this work was to investigate the feasibility of utilizing organic or aqueous forms of ethylcellulose (EC) for the preparation of microparticles with RUP by the spray drying technique. Spray dried samples at different drug:polymer ratios were prepared using organic solution (Ethocel®) or aqueous dispersions of EC (Surelease®, Aquacoat® ECD). Evaluation of the taste masking efficacy was performed in vivo in human taste panel, in vitro based on dissolution test, and by self-constructed electronic tongue. It was shown that microparticles obtained from aqueous dispersions of EC have superior pharmaceutical properties in terms of both morphology and taste masking efficacy in comparison to those obtained from organic solution.

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Section: Resultsmentioning

confidence: 99%

Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate

et al. 2019

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“…Application of EC microparticles containing naproxen to textile materials was studied by Arici et al Microparticles were prepared by spray-drying using an aqueous EC dispersion and applied to orthopedic support materials. Since these materials are used for traumatic irritations, over-forced ligaments and tendons, and specific problems of various joints, it was concluded that they can serve as potential drug delivery systems [102].…”

Section: Applicability Of Ec In Pharmaceutical Formulationsmentioning

confidence: 99%

Ethylcellulose–A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development

2019

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Polymers constitute the most important group of excipients utilized in modern pharmaceutical technology, playing an essential role in the development of drug dosage forms. Synthetic, semisynthetic, and natural polymeric materials offer opportunities to overcome different formulative challenges and to design novel dosage forms for controlled release or for site-specific drug delivery. They are extensively used to design therapeutic systems, modify drug release, or mask unpleasant drug taste. Cellulose derivatives are characterized by different physicochemical properties, such as swellability, viscosity, biodegradability, pH dependency, or mucoadhesion, which determine their use in industry. One cellulose derivative with widespread application is ethylcellulose. Ethylcellulose is used in pharmaceutical technology as a coating agent, flavoring fixative, binder, filler, film-former, drug carrier, or stabilizer. The aim of this article is to provide a broad overview of ethylcellulose utilization for pharmaceutical purposes, with particular emphasis on its multidirectional role in the development of oral and topical drug dosage forms.

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“…These morphological characteristics point out that the CHD is dispersed all over the MPs (Figure 1). In other spray-drying studies performed by using aqueous polymeric dispersions, MPs with similar morphological characteristics were also obtained (Rattes, 2007;Arici, 2014). …”

Section: Particle Morphologymentioning

confidence: 74%

Encapsulated Chlorhexidine Digluconate Usage on the Diabetic Footwear Lining Leathers

Karavana¹,

Rençber²,

Karavana³

et al. 2016

The International Conference on Advanced Materials and Systems

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TURKEYIt is important for a therapeutic shoe to have a wearable quality and its comfortable use is also prominent in terms of providing an increase in user's quality of life. In long-term treatment of diseases, medical products which are to be manufactured with medical leather materials might be a prominent alternative via local effect application as an adjuvant to the treatment. It is aimed in this study to produce microparticles (MPs) which contain the active agent chlorhexidine digluconate and application of these MPs on lining leather for manufacturing diabetic shoes while providing them a functional quality. Within the scope of the project, MPs loaded with drugs were obtained via spraying chlorhexidine digluconate (CHD) active agent and through spraying with ethyl cellulose polymer and ustulation. In vitro characterisation studies were performed on the acquired MPs. Additionally, active agent quantitation and in vitro drug delivery studies were also performed. Following the studies, the determined optimum MP formulations were applied on the leather, then existence and efficiency of MPs within the leather was shown in the subsequent studies.

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Preparation of naproxen–ethyl cellulose microparticles by spray-drying technique and their application to textile materials

Cited by 19 publications

References 53 publications

Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate

Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate

Ethylcellulose–A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development

Encapsulated Chlorhexidine Digluconate Usage on the Diabetic Footwear Lining Leathers

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