Preparation of Novel Derivatives of Pyridothiazine‐1,1‐dioxide and Their CNS an Antioxidant Properties.

Abstract

Thiazine derivatives Thiazine derivatives R 0610Preparation of Novel Derivatives of Pyridothiazine-1,1-dioxide and Their CNS an Antioxidant Properties. -Starting from isothiazolopyridine-1,1-dioxide (I), the title compounds (VI) possessing the 3-[4-(substituted-phenyl)piperazinyl]propyl or 3-(4-substituted-piperidinyl)propyl side chain at the thiazine nitrogen atom are prepared and evaluated for their acute toxicity and for their influence on the spontaneous locomotor activity, thiopental anaesthesia, carrageenan induced edema and analgesic activity. -(MALINKA*, W.; KACZMARZ, M.; FILIPEK, B.; SAPA, J.; GLOD, B.; Farmaco 57 (2002) 9, 737-746; Dep. Chem. Drugs, Wroclaw Univ. Med., PL-50-137 Wroclaw, Pol.; Eng.) -R. Langenstrassen 04-160

In vitro and in vivo biochemical activities of novel copper complexes of chrysin derivatives of organosulfur compounds based potential therapeutic agent: design, synthesis, characterization and pharmacological studies

“…Diorganyl disul des are exible building blocks for the synthesis of different organic sulfur compounds as they have a unique and rich synthetic and biochemical chemistry [6,7]. In the garlic, onions and mahogany trees, some naturally occurring disul des such as ajoene and dysoxysulfone are present and have shown promising antifungal [8-10], antibacterial [11], antibiotic [12], antitumor [13], anti-malarial [14] and analgesic [15] properties. Commercially available disul des are mainly used for the production of sulfuric acid [16] rubber vulcanization [17] and for the manufacture of essential reagents such as carbon disul de CS 2 , phosphorus pentasul de P 2 S 5 [18], etc.…”

Synthesis, spectral characterization, and in vitro antibacterial and antifungal activities of novel 1,3-thiazine-2-amines comprising morpholine nucleus

“…2-Amino-1,3-thiazines and their derivatives are chemically and pharmaceutically interesting entities, and have been used as antimicrobial agents 1 , as cannabinoid receptor agonists 2 , in the discovery of CB2 receptors 3 , in the phagocytic activity of human neutrophils 4 , as vasopressin receptor antagonists 5 , and have central nervous system (CNS) and antioxidant properties 6 , analgesic and anti-inflammatory activities 7 , antifilarial properties 8 , metalloprotease inhibition activity 9 , and antihypertensive activity 10 . The presence of the N-C-S linkage is believed to account for the extensive biological activities of the thiazine nucleus.…”