Preparation of Novel Nanoformulation to Enhance Efficacy in the Treatment of Cardiovascular Disease

Abstract

Despite many efforts over the last few decades, cardiac-based drug delivery systems are experiencing major problems, such as the effective delivery of the precise amount of a drug. In the current study, an effort has been made to prepare a nano-herbformulation (NHF) to overcome the major problem of conventional intervention. Copper oxide-based NHF was prepared using plant extract of Alternanthera sessilis and characterized using physicochemical techniques such as Transmission electron microscopy (TEM), X-ray powder diffraction (XRD), Dynamic light scattering (DLS), UV-Vis spectroscopy, and Fourier-transform infrared spectroscopy (FTIR). TEM analysis revealed that spherical NHF obtained of size 20–50 nm. In addition, XRD and FTIR confirmed the presence of phytochemicals with biological properties over the surface of copper oxide-based NHF. It was demonstrated that dose-dependent antiapoptotic activity was shown against DOX-induced cardiomyocytes, where ROS levels were significantly reduced to 0.29% from 37.99%. The results of the flow cytometry analysis using PI and Annexin staining further confirmed the antiapoptotic activity of NHF against DOX-induced cardiomyocytes by ROS scavenging. Thus, NHF might be used for cardiovascular disease treatment.

From Nature to Technology: Exploring the Potential of Plant-Based Materials and Modified Plants in Biomimetics, Bionics, and Green Innovations

“…Carbon-based nanomaterials, in particular, have been noted to impact various plant functions [316]. These NPs offer protective benefits, such as shielding plants from UV radiation by reducing UV absorption, as evidenced in multiple studies [316][317][318]. For example, exposure to carbon NPs at concentrations of 40-60 mg/L has been shown to promote plant regeneration and improve the root/bud ratio in V. zizanioides [303].…”

Biomimetic Nanotechnology Vol. 3

“…In the first article, the authors investigate the 4D printing of self-folding and self-assembling structures as a means to better understand the formation of viral capsids, an area of research that has gained considerable importance in the wake of the COVID-19 pandemic [ 5 ]. The second article combines traditional Indian Siddha medicine with nanotechnology to explore novel approaches for treating cardiovascular diseases [ 6 ]. The third article is a comprehensive review of fungi-mediated synthesis of nanoparticles, including those of common metals such as Silver and Gold, as well as less commonly studied metals such as Tellurium and Selenium [ 7 ].…”

“…The work “Preparation of Novel Nanoformulation to Enhance Efficacy in the Treatment of Cardiovascular Disease” [ 6 ] with authors from India, Korea and Ethiopia is an intriguing combination of traditional medicine, modern nanomedicine and state-of-the art analytical techniques. The article describes a new way of delivering Copper to heart cells, as a means to establish a nanoparticle-based drug delivery system utilizing Copper oxide-based nanoherb formulations.…”