Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin

Cai, Shuwei; Li, Xian; Pu, Shijie; Ma, Xinyu; He, Xianru

doi:10.1080/00914037.2022.2090355

International Journal of Polymeric Materials and Polymeric Biom

2022

DOI: 10.1080/00914037.2022.2090355

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Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin

Shuwei Cai

Xian Li

Shijie Pu

et al.

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Cited by 2 publications

References 34 publications

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Controlled release of therapeutic antibody using hydrolytically degradable microgels

Mora‐Boza,

Ahmedin,

García

2023

J Biomedical Materials Res

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Monoclonal antibodies have gained significant interest as potential therapeutics for treating various diseases. However, these therapies are not always effective due to poor treatment compliance associated with multiple administrations and drug resistance. Thus, there is a growing interest in developing advanced monoclonal antibody delivery systems that can customize pharmacokinetics to enhance therapeutic outcomes. This work aimed to engineer hydrolytic 4‐arm PEG maleimide (PEG‐4MAL) microgels for the controlled delivery of therapeutic antibodies, specifically anti‐angiogenic bevacizumab, to overcome the limitations of current monoclonal antibody therapies. Through a PEGylation reaction with a thiol‐terminated PEG linker, the antibody was covalently conjugated to the macromer backbone before microgel synthesis. The PEGylation reaction was simple, effective, and did not affect antibody bioactivity. Antibody release kinetics was tuned by changing the concentration of the hydrolytic linker (0–2 mM) and/or PEG‐4MAL:protein molar ratio (1000:1, 2000:1, and 5000:1) in the macromer precursor solution during microgel fabrication. The bioactivity of the released antibody was assessed on human umbilical endothelial vascular cells (HUVEC), demonstrating that extracts from hydrolytic microgels reduced cell proliferation over time. Collectively, this study demonstrates the development of highly tunable delivery platform based on degradable PEG‐4MAL microgels that can be adapted for therapeutic antibody‐controlled release.

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Controlled release of therapeutic antibody using hydrolytically degradable microgels

Mora‐Boza,

Ahmedin,

García

2023

J Biomedical Materials Res

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pH-Responsive Deacetylated Sphingan WL Gum-Based Microgels for the Oral Delivery of Ciprofloxacin Hydrochloride

Huang,

Dong,

Qiu

et al. 2024

ACS Omega

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Sphingan WL gum (WL) is an extracellular polysaccharide with a carboxyl group produced by Sphingomonas sp. WG. Recently, we have successfully obtained deacetylated WL (DWL) with good water solubility by alkaline treatment. In this study, a DWL-based microgel (named DWLM) with semi-interpenetrating network structure was constructed for the first time and used to deliver the oral drug ciprofloxacin hydrochloride (CIP). DLS results suggested that DWLM had a dual response to pH and temperature. The in vitro cumulative drug release curves showed that the amount of CIP released from the microgel was higher at pH 6.8 than that at pH 3.0. Biocompatibility assessments using HEK293T showed that cell viability was 75.9 ± 1.7% at the DWLM-CIP concentration of 4 mg/mL. While, the cell viability of CIP at the same concentration was only 54.9 ± 1.0%, indicating that DWLM-CIP has good biocompatibility. Antimicrobial performance tests revealed that DWLM-CIP at a concentration of 1 mg/mL could effectively inhibit the growth of Escherichia coli for up to 4 days. When the concentration of DWLM-CIP reached 4 mg/mL, the growth of Staphylococcus aureus was effectively suppressed for up to 3 days, demonstrating the long-lasting antimicrobial efficacy of DWLM-CIP. All of these results indicate that DWL-based microgels have great potential as oral drug delivery carriers.

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Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin

Cited by 2 publications

References 34 publications

Controlled release of therapeutic antibody using hydrolytically degradable microgels

Controlled release of therapeutic antibody using hydrolytically degradable microgels

pH-Responsive Deacetylated Sphingan WL Gum-Based Microgels for the Oral Delivery of Ciprofloxacin Hydrochloride

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