Preparation of Poly Acrylic Acid-Poly Acrylamide Composite Nanogels by Radiation Technique

Ghorbaniazar, Parisa; Sepehrianazar, Amir; Eskandani, Morteza; Nabi-Meibodi, Mohsen; Kouhsoltani, Maryam; Hamishehkar, Hamed

doi:10.15171/apb.2015.037

Cited by 21 publications

(15 citation statements)

References 26 publications

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“…5) confirmed the presence of vibrational bands at 442, 518, 567, 662, and 667 cm −1 [31]. The bands at 1122, 1193, and 1329 cm −1 [31,32] could be attributed to C-C stretching vibrations, C-C bending vibrations, and C-H bending vibrations, respectively. The absorption IR spectrum of PAM bands located at 3393, 3120, 1686, and 1598 cm −1 [31][32][33] were attributed to the asymmetric and symmetric NH 2 stretching vibrations, amide I (-CO and -CN), and amide II (-NH and -CN).…”

Section: Ft-ir Spectrummentioning

confidence: 74%

Facile synthesis of silver nanoparticles mediated by polyacrylamide‐reduction approach to antibacterial application

Salaheldin

Almalki

Hezma

et al. 2017

IET nanobiotechnol.

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The current time increase in the prevalence of antibiotic resistant 'super-bugs' and the risks associated with food safety have become global issues. Therefore, further research is warranted to identify new and effective antimicrobial substances. Silver nanoparticles (Ag-NPs) were synthesized by autoclaving technique using, different concentrations of Ag salt (AgNO) solution (1, 5, 10, and 25 mM). Their presence was confirmed by a surface plasmon resonance band at ∼435 nm using UV-Vis absorption spectra. The morphology of the synthesized Ag-NPs stabilized by polyacrylamide (PAM) was examined by TEM, SAED, and EDS. TEM images revealed that the synthesized Ag-NPs had an average diameter of 2.98±0.08 nm and SAED and EDS results confirmed the formation of Ag-NPs. In addition, FT-IR spectroscopy revealed that a PAM polymer matrix stabilized the Ag-NPs. The well diffusion method, was used to test, Gram positive and Gram negative bacteria were examined. Also the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were studied against Ag-NPs. The Ag-NPs exhibited strong inhibitory activity, MIC and MBC against the tested clinical bacterial isolates. These results suggest that Ag-NPs stabilized in PAM are highly effective against clinical bacterial isolates can be applied in medical fields.

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Section: Ft-ir Spectrummentioning

confidence: 74%

Facile synthesis of silver nanoparticles mediated by polyacrylamide‐reduction approach to antibacterial application

Salaheldin

Almalki

Hezma

et al. 2017

IET nanobiotechnol.

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“…In this work no cytotoxic effect were observed after culture the cell lines in the presence of nanocomposites, these results suggest that all the nanocomposites under study are biocompatible. Similarly, pH sensitive hydrogels based on poly-acrylamide, polyacrylic acid and chitosan also have been found cytocompatible [29,30]. However, Povea et al, [31] found that some hydrogels showed cytotoxic effect after seven days presenting viability lower than 80% respect to the control.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties

Bellingeri

Mulko

Molina

et al. 2018

Materials Science and Engineering: C

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The present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes to acrylamide-co-acrylic acid hydrogels. The nanocomposites chemical structure was characterized by Fourier Transform Infrared Spectroscopy (FT-IR). The FT-IR shows the typical bands due to the hydrogel and additionally the peaks at 1750 cm and 1450 cm that correspond to the carbon nanotubes incorporated into the polymer matrix. Mechanical properties and swelling measurements in different buffer solutions were also performed. The nanocomposites showed improved mechanical properties and a stronger pH-response. In order to evaluate antimicrobial activity, the growth and adhesion of Staphylococcus aureus to nanocomposites were studied. Cytocompatibility was also evaluated by MTT assay on MDCK and 3T3 cell lines. The nanocomposites were found to be cytocompatible and showed a reduced bacterial colonization.

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“…To ensure quick and accurate analysis, a rapid physical response of the hydrogel is critical for the success of stimuli‐responsive hydrogel‐based biosensors. Various gel‐forming hydrophilic polymers have been developed such as poly(NIPAAM), pluronic, chitosan, and polyacrylic acid . Applications of hydrogels can be differentiated, depending on their responses to the physical or chemical stimuli .…”

Section: Introductionmentioning

confidence: 99%

Hydrogel Based Biosensors for In Vitro Diagnostics of Biochemicals, Proteins, and Genes

Jung

Kim

Choi

et al. 2017

Adv Healthcare Materials

150

105

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Hydrogel‐based biosensors have drawn considerable attention due to their various advantages over conventional detection systems. Recent studies have shown that hydrogel biosensors can be excellent alternative systems to detect a wide range of biomolecules, including small biochemicals, pathogenic proteins, and disease specific genes. Due to the excellent physical properties of hydrogels such as the high water content and stimuli‐responsive behavior of cross‐linked network structures, this system can offer substantial improvement for the design of novel detection systems for various diagnostic applications. The other main advantage of hydrogels is the role of biomimetic three‐dimensional (3D) matrix immobilizing enzymes and aptamers within the detection systems, which enhances their stability. This provides ideal reaction conditions for enzymes and aptamers to interact with substrates within the aqueous environment of the hydrogel. In this review, we have highlighted various novel detection approaches utilizing the outstanding properties of the hydrogel. This review summarizes the recent progress of hydrogel‐based biosensors and discusses their future perspectives and clinical limitations to overcome.

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Preparation of Poly Acrylic Acid-Poly Acrylamide Composite Nanogels by Radiation Technique

Cited by 21 publications

References 26 publications

Facile synthesis of silver nanoparticles mediated by polyacrylamide‐reduction approach to antibacterial application

Facile synthesis of silver nanoparticles mediated by polyacrylamide‐reduction approach to antibacterial application

Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties

Hydrogel Based Biosensors for In Vitro Diagnostics of Biochemicals, Proteins, and Genes

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