Preparation of polydopamine-modified celastrol nanosuspension and its anti-liver cancer activity in vitro

Chen, Gongsen; Liu, Yuling; Shi, Guolin; Luo, Yuting; Sai, Fu; Yang, Anhui; Zhou, Yingying; Wu, Yanqiu; Lin, Liwu; Li, Hui

doi:10.1016/j.jddst.2022.103630

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…The XRD patterns of CSL showed its characteristic peaks at 2θ ranging from 5 to 25 • , especially at 6.3, 11.8, 13.4, 14.2, 14.6, 16.0, 16.9, and 22.9 • . These sharp signal peaks indicated the highly crystalline structure of CSL, which was consistent with previous reports [37,38]. For the physical mixtures of G2/CSL and G2-C18/CSL, several intense peaks were shown in the diffractogram, including at 12.0, 13.4, 14.2, 14.6, 16.0, and 16.9 • .…”

Section: X-ray Powder Diffraction (Xrd) Analysissupporting

confidence: 90%

Effect of Lipophilic Chains on the Antitumor Effect of a Dendritic Nano Drug Delivery System

Ding

Wang

et al. 2022

Molecules

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Oligoethylene glycol dendron (G2) has been used in drug delivery due to its unique dendritic structure and excellent properties. In order to investigate the effects of lipophilic chains on drug delivery, the amphiphilic hybrid compound G2-C18 is synthesized, and celastrol (CSL) is selected to prepare “core-shell” structured CSL-G2-C18 nanoparticles (NPs) via the antisolvent precipitation method. Meanwhile, CSL-G2 NPs are prepared as the control. The two NPs show similar particle sizes and polydispersity indexes, while their morphologies exhibit dramatic differences. CSL-G2 NPs are solid spherical particles, while G2-C18 NPs are vesicles. The two NPs present ideal stability and similar release tendencies. The in vitro toxicity results show that the cell inhibition effect of CSL-loaded NPs is significantly enhanced when compared with free CSL, and the antitumor effect of CSL-G2-C18 NPs is stronger than that of CSL-G2 NPs. The IC50 value of CSL-G2 NPs and CSL-G2-C18 NPs is enhanced about 2.8-fold and 5-fold when compared with free CSL, respectively. The above results show that lipophilic chain-linking dendritic hybrid nanocarriers promote antitumor activity by affecting the morphology of NPs, which may aid in the selection of carrier designs.

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Section: X-ray Powder Diffraction (Xrd) Analysissupporting

confidence: 90%

Effect of Lipophilic Chains on the Antitumor Effect of a Dendritic Nano Drug Delivery System

Ding

Wang

et al. 2022

Molecules

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“…It has a significant inhibitory effect on the progression of liver tumors, 144 although its systemic toxicity, low solubility, and low bioavailability hinder its clinical application. 145–148 A glycyrrhetinic acid-modified CMCS–thioketol–rhein conjugate, developed for the delivery of celastrol (Cela/GCTR PMs), is responsive to ROS in vitro , which improves celastrol bioavailability and HCC targeting. It can effectively inhibit tumor growth and does not damage organs.…”

Section: Therapeutic Applications Of Chm-derived Nanostructuresmentioning

confidence: 99%