Preparation of Polymer/Drug Nano‐ and Micro‐Particles by Electrospraying

Park, Chul Ho; Kim, Min Young; Yoo, Ji Youn; Kim, Ki‐Hyun; Lee, Jong-Chan; Lee, Jonghwi

doi:10.1002/masy.200750319

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…The ES of a 0.5 wt% solution of PCL into water without stirring led to formation of a thin film on the water surface, while a 0.5 wt% of PMMA resulted in particles of 2 μm size. On the other hand, 1 wt% triphenyl phosphate buffer was an efficient collection medium for ES of chitosan nanoparticles, while it was not effective for PCL (Park et al, 2007). These results indicate that the interactions between the particle and collection media are critical for obtaining well-dispersed particles.…”

Section: Factors Affecting the Quality Of Es Particlesmentioning

confidence: 99%

Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review

Boda

Xie

2018

Journal of Aerosol Science

144

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Electrospraying (ES) is a robust and versatile technique for the fabrication of micro- and nanoparticulate materials of various compositions, morphologies, shapes, textures and sizes. The physics of ES provides a great degree of flexibility towards the materials design of choice with desired physicochemical and biological properties. Not surprising, this technology has become an important tool for the production of micro- and nanostructured materials, especially in the pharmaceutical and biomedical arena. In this review, a basic introduction to the fundamentals of ES along with a brief description of the experimental parameters that can be manipulated to obtain micro- and nanostructured materials of desired composition, size, and configuration are outlined. A greater focus of this review is to bring to light the broad range of electrosprayed materials and their applications in drug delivery, biomedical imaging, implant coating, tissue engineering, and sensing. Taken together, this review will provide an appreciation of this unique technology, which can be used to fabricate micro- and nanostructured materials with tremendous applications in the pharmaceutical and biomedical fields.

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Section: Factors Affecting the Quality Of Es Particlesmentioning

confidence: 99%

Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review

Boda

Xie

2018

Journal of Aerosol Science

144

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“…In more detail, the difference in surface tension of the collecting solutions affected the degree of particle compression, which consequently, led toward a different deformation of particles. 98 The influence of collection and consolidation media on the particle formation and properties was also confirmed in a study by Park et al 99 Other processing parameters such as temperature and relative humidity are worth mentioning as they play an important role in the solidification process of electrosprayed droplets as well as for polymer diffusion inside the droplets, which in turn will determine the particle quality, especially the particle morphology. Besides, higher temperature not only favors faster evaporation but also increases molecular mobility and solution conductivity as well as decreases solution viscosity which all contribute to a possible decrease in particle size.…”

Section: Processerelated Parametersmentioning

confidence: 60%

Pharmaceutical Applications of Electrospraying

Nguyen

Clasen

Mooter

2016

Journal of Pharmaceutical Sciences

157

128

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The electrohydrodynamic atomization technique, or simply called electrospraying, has been extensively studied for biomedical as well as for pharmaceutical applications over the past years. The simplicity, flexibility, and efficiency of producing particles at the microscale or nanoscale, with tailored size, shape, morphology, and microstructure, make electrospraying to become one of the most promising and well-practiced approaches to be applied in many biomedical and pharmaceutical fields, from improving the bioavailability of poorly aqueous soluble drugs, preparing targeted drug delivery systems, and controllable drug release systems to delivering sensitive therapeutic agents such as protein-based drugs or even living cells. Nevertheless, some issues still remain with respect to low throughput as well as the complex interplay between a great number of processing and formulation factors. A comprehensive understanding of these fundamental aspects is essential for the successful application of electrospraying for the production of particulate formulations with desired properties.

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“…Usually, the setup for collecting the particles produced by electrospraying is a hard surface located on the counter electrode. Nevertheless, different authors have published an alternative “soft” collecting approach where the droplets or particles are caught in liquid medium [ 222 , 223 , 224 , 225 ]. One of the benefits of this collecting method is the prevention of possible particle aggregation or film formation on the hard collector [ 223 ].…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

et al. 2020

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Spray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle engineering. To get a better understanding of how functional particles are formed with respect to process and formulation parameters, it is indispensable to offer a comprehensive overview of critical aspects of the droplet drying and particle formation process. This review therefore closely relates single droplet drying to pharmaceutical applications. Although excellent reviews exist of the different aspects, there is, to the best of our knowledge, no single review that describes all steps that one should consider when trying to engineer a certain type of particle morphology. The findings presented in this article have strengthened the predictive value of single droplet drying for pharmaceutical drying applications like spray drying and electrospraying. Continuous follow-up of the particle formation process in single droplet drying experiments hence allows optimization of manufacturing processes and particle engineering approaches and acceleration of process development.

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Preparation of Polymer/Drug Nano‐ and Micro‐Particles by Electrospraying

Cited by 8 publications

References 9 publications

Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review

Electrospraying an enabling technology for pharmaceutical and biomedical applications: A review

Pharmaceutical Applications of Electrospraying

Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

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