Preparation of polymeric composition of linezolid and study of its antimicrobial activity in vitro

Novikova, A. A.; Zavarzina, V. V.; Vorontcov, E. A.; Северин, С. Е.; Severin, E. S.

doi:10.1134/s1995078014040132

Cited by 1 publication

(4 citation statements)

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“…Therefore, the FTIR spectra of (Blend/(0.1 ml) Tween(80)) after adding different amounts of (Linezolid drug) displayed speci c bands for the drug within the investigation region between 4000 − 400 cm − 1 as shown in Fig. (3). Moving to the FTIR of (Blend/(0.1 ml) Tween(80)/ (20,40,60 and 80 mg/g) Linezolid drug), it is spotted that there are additional peaks are appeared.…”

Section: X-ray Diffraction Scans (Xrd)mentioning

confidence: 98%

“…) and Fig. (13(a-e))[3,4]. It has been observed that the e cacy of the combination of blend/(0.1ml) Tween(80)/ Linezolid for killing or averting the microbes and fungus diffusion which means that C.albicans for sample (3) is more sensitive than the other tested microbes towards the effect of Linezolid.…”

mentioning

confidence: 91%

“…Native antibiotics can perform a signi cant function to avert and cure various dominant dermal pathogenic contagions such as regional super cial contagions owing to trauma, and abrasion. Linezolid is an antibacterial agent that is forcefully used for the treatment of complicated skin and skin structure infections (SSSIs), including diabetic foot infections (DFIs) without concomitant osteomyelitis averse to wound pathogens inclusive Methicillin-Resistant Staphylococcus aureus (MRSA) [3].…”

Section: Introductionmentioning

confidence: 99%

“…Linezolid was identi ed chemically as (S)-N-[[3-(3 uoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl] methyl] acetamide which meditated as the rst member of the class of oxazolidinone antibiotics that performs by inhibiting the initiation of bacterial protein synthesis and terri c pharmacokinetic index [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Functionalized Sodium carboxymethyl cellulose/Sodium alginate-Based Tween (80) for Potential Allocation of Linezolid as Antimicrobial Agents

El-bana

Abdelghany²,

Meikhail³

2022

Preprint

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Innovative adhesive bio-films were developed for antimicrobial wound bandages. The bio-films are prepared by blending natural polymers such as sodium carboxymethyl cellulose and sodium alginate with a surfactant as Tween(80) and loaded with Linezolid drug as antimicrobial agents. In this paper, polymeric films were prepared by casting film-forming method. Prefatory studies comprised XRD, FTIR, UV/vis spectroscopy, and SEM to specify lattice structure, interactions, optical properties, and morphology. Antibacterial analysis was also performed by agar well diffusion tests. The effect of bio-film composition on E.coli, P.aeuroginosa, S.aureus, B.subtilis standard bacteria, and C.albicans pathogenic fungus was studied and compared with biomaterial film without Linezolid drug. The in vitro antibacterial assay of bio-films formulations was assessed in bacterial and fungal strains, showing a significant activity over time rather than control bio-film. Finally, the preparation of biomaterial films loaded with Linezolid drug (antimicrobial wound dressings) is an environmentally friendly solution that may contribute to the development of wound healing.

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Section: X-ray Diffraction Scans (Xrd)mentioning

confidence: 98%

mentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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