Preparation of surface molecularly imprinted polymers as the solid-phase extraction sorbents for the specific recognition of penicilloic acid in penicillin

Luo, Zhimin; Zeng, Aiguo; Zheng, Penglei; Guo, Pengqi; Du, Wei; Du, Kangli; Fu, Qiang

doi:10.1039/c4ay01515k

Cited by 28 publications

(20 citation statements)

References 38 publications

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“…The binding specificity properties of SMIPs have been studied in our previous research, and it proved that SMIPs not only exhibited high selectivity towards PNLA (Q max ¼ 22.67 mg g À1 ) but also presented the adsorption capacity for its analogues (Luo et al, 2014). In Fig.…”

Section: Adsorption and Selectivitymentioning

confidence: 97%

“…The preparation of SMIPs has been specifically described in authors' previous research (Luo et al, 2014). The SMIPs was synthesized by use of modified silica gel (20 mg) as support, 20 mL of methanol and acetonitrile (1:1, v/v) as solvent, penicilloic acid (0.5 mmol) as template molecule and methacrylic acid (2 mmol) as functional monomer for prepolymerisation (15 h).…”

Section: Synthesis Of Surface Molecular Imprinted Polymersmentioning

confidence: 99%

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Molecularly imprinted polymer cartridges coupled to liquid chromatography for simple and selective analysis of penicilloic acid and penilloic acid in milk by matrix solid-phase dispersion

Luo

Zheng

et al. 2015

Food and Chemical Toxicology

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Section: Adsorption and Selectivitymentioning

confidence: 97%

Section: Synthesis Of Surface Molecular Imprinted Polymersmentioning

confidence: 99%

Molecularly imprinted polymer cartridges coupled to liquid chromatography for simple and selective analysis of penicilloic acid and penilloic acid in milk by matrix solid-phase dispersion

Luo

Zheng

et al. 2015

Food and Chemical Toxicology

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“…The MIP prepared by surface imprinting approach has more recognition sites at the surface of material which encourage a quick mass exchange, fast recognition and more recoveries. The surface molecularly imprinted polymers (SMIPs) show great strength at different pH values, extraordinary mechanical quality at different temperatures, and robustness in various solvents [26]. SPE advanced subdivisions such as dispersive SPE (DSPE), stir-bar sportive extraction, solid phase micro extraction, and single drop micro extraction, are considered as highly selective, less expensive and more environment friendly as compared to conventional extraction methods [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Development of Surface Molecularly Imprinted Polymers as Dispersive Solid Phase Extraction Coupled with HPLC Method for the Removal and Detection of Griseofulvin in Surface Water

Bashir

Luo

Chen

et al. 2019

IJERPH

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Griseofulvin (GSF) is clinically employed to treat fungal infections in humans and animals. GSF was detected in surface waters as a pharmaceutical pollutant. GSF detection as an anthropogenic pollutant is considered as a possible source of drug resistance and risk factor in ecosystem. To address this concern, a new extraction and enrichment method was developed. GSF-surface molecularly imprinted polymers (GSF-SMIPs) were prepared and applied as solid phase extraction (SPE) sorbent. A dispersive solid phase extraction (DSPE) method was designed and combined with HPLC for the analysis of GSF in surface water samples. The performance of GSF-SMIPs was assessed for its potential to remove GSF from water samples. The factors affecting the removal efficiency such as sample pH and ionic strength were investigated and optimized. The DSPE conditions such as the amount of GSF-SMIPs, the extraction time, the type and volume of desorption solvents were also optimized. The established method is linear over the range of 0.1–100 µg/mL. The limits of detection and quantification were 0.01 and 0.03 µg/mL respectively. Good recoveries (91.6–98.8%) were achieved after DSPE. The intra-day and inter-day relative standard deviations were 0.8 and 4.3% respectively. The SMIPs demonstrated good removal efficiency (91.6%) as compared to powder activated carbon (67.7%). Moreover, the SMIPs can be reused 10 times for water samples. This is an additional advantage over single-use activated carbon and other commercial sorbents. This study provides a specific and sensitive method for the selective extraction and detection of GSF in surface water samples.

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“…MIPs exhibit a wonderful application potential in the field of the recognition of amino acids, proteins and nucleotide derivatives. Their most extensively investigated application has been as separation materials for the analysis of various compounds, including drugs, 16 pesticides, 17 trace elements, 18 proteins 6 and nucleotides 19 . After removing the template, a customized three-dimensional nanocavity is formed with complementary binding sites for the target.…”

Section: Introductionmentioning

confidence: 99%

A porous hybrid imprinted membrane for selectively anchoring target proteins from a complex matrix

Luo

Guo

et al. 2015

RSC Adv.

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A novel porous hybrid imprinted membrane (CP/CNT/DA-MIM) was prepared that could selectively anchor and separate target proteins from a complex matrix. CP/CNT/DA-MIM takes advantage of molecularly imprinted polymers and membranes, including the high selectivity of MIPs and the lower energy consumption and continuously separating mixtures of the membrane separation. The surface morphologies and physical/chemical properties of different membranes were investigated using FTIR, XRD, DSC, XPS and SEM. The results showed that the different molecules contained in CP/CNT/DA-MIM were homogeneous; two different sizes of imprinted cavities were observed in CP/CNT/DA-MIM that facilitate the selective anchoring property. The adsorption capacity, swelling behavior and mechanical properties of different constituent membranes were also compared. The results showed that the adhesion and nonspecific adsorption properties of the membrane were manifestly reduced by the addition of PVP. The binding capacity and adsorption selectivity of the membrane were apparently improved because of the existence of dopamine. MWCNTs obviously promoted the mechanical strength of the 2 membranes. CP/CNT/DA-MIM was successfully applied to separate bovine serum albumin from bovine blood. CP/CNT/DA-MIM is an economical, hydrophilic and eco-friendly membrane and provides a promising separation material for the large-scale continuous selective separation of target proteins from a complex matrix in commercial applications. 4 low-molecular-weight compounds. 12-14 Although several imprinting techniques for creating protein MIPs have been developed, 1,2 protein imprinting still faces challenges due to the inherent properties of proteins, including their complicated physicochemical properties, large sizes, poor solubility, sensitivity to chemical process and the limited viability in organic solvents, which is usually essential for MIP formation. 21 Chitosan (CS), which contains abundant amino and hydroxyl groups, has remarkable affinity to proteins. 22 CS is a linear hydrophilic polysaccharide derived from the deacetylation of chitin, which is one of the most plentiful natural biopolymers. CS has a relatively good film-forming ability and is eco-friendly and safe for humans and the environment. 23 Furthermore, it is a biocompatible and biodegradable material with attractive properties, including hydrophilicity, biocompatibility, nontoxicity and high permeability toward water. 24 These endow CS with a wide usage in molecular separation, wastewater treatment, packaging materials, artificial skin, cosmetics, bone substitutes, and so on. 25 Moreover, CS has been widely used as a supporter or functional monomer for the recognition and immobilization of proteins. 26,27 However, the specific adsorption of CS for target proteins is unsatisfactory because of the abundant functional groups in CS. 22 Additionally, the fragility, the uncontrollable porosity and the adhesive property of chitosan matrices limit the feasibility and practicability in membrane separation. 25 T...

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Preparation of surface molecularly imprinted polymers as the solid-phase extraction sorbents for the specific recognition of penicilloic acid in penicillin

Abstract: The schematic representation of the route for the synthesis of SMIPs and the analysis of samples.

Cited by 28 publications

References 38 publications

Molecularly imprinted polymer cartridges coupled to liquid chromatography for simple and selective analysis of penicilloic acid and penilloic acid in milk by matrix solid-phase dispersion

Molecularly imprinted polymer cartridges coupled to liquid chromatography for simple and selective analysis of penicilloic acid and penilloic acid in milk by matrix solid-phase dispersion

Development of Surface Molecularly Imprinted Polymers as Dispersive Solid Phase Extraction Coupled with HPLC Method for the Removal and Detection of Griseofulvin in Surface Water

A porous hybrid imprinted membrane for selectively anchoring target proteins from a complex matrix

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