Preparation of tetracycline microparticles suitable for inhalation administration by supercritical fluid expansion depressurization

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

“…[ 52 ] SCF-expansion depressurization (SFED) process is another innovative technique, which has shown great potential in micronization of water-soluble drugs, where SCF acts neither as solvent nor anti-solvent; however, when SCF is in contact with ternary phase mixture, it starts dissolving in the solution. [ 53 ]…”

“…Increased demand of pharmaceutical industries in developing new approaches for drug delivery, has evidenced the SCF technology as an alternative [ 55 ] for the syntheses of micro- [ 35 , 56 ] as well as nano-size particles [ 20d,e , 57 ] with homogenous size distribution and high-performance. [ 21a ] Indeed, this technology has been used to manufacture various formulations of different drug categories such as those treating anesthesia, [ 58 ] antibiotics, [ 53 , 59 ] asthma, [ 60 ] cancer, [ 61 ] central nervous system, [ 62 ] cardiovascular system, [ 31a ] diabetes, [ 28 ] diuretics, [ 63 ] inflammation (steroidal [ 64 ] and non-steroidal anti-inflammatory agents [ 65 ] ), lipid-lowering, [ 66 ] among others, administered through oral, [ 67 ] intravenous, [ 41 ] ophthalmic, [ 68 ] pulmonary, [ 47 ] transdermal, [ 61c ] and polymeric implants for sustained delivery. [ 69 ] Revercheon et al have highlighted the production of various nanoconstructs such as nanoparticles, [ 70 ] nanofibers, [ 71 ] nanowires, [ 72 ] nanotubes, [ 73 ] and other nanostructured materials using supercritical-based techniques.…”

Assessment of the liquid mixture density effect on the prediction of supercritical carbon dioxide volume expansion of organic solvents by Peng-Robinson equation of state

“…For this reason it can be considered as a clean technology compared to conventional micronization techniques such as freeze-drying, spray drying, solvent evaporation or jet milling. Also SCF physical and transport properties are intermediate between those of a gas and a liquid offering the possibility of process intensification [1,2,3].…”