Preparation of Thermoresponsive Polymer Nanogels of Oligo(Ethylene Glycol) Diacrylate-Methacrylic Acid and Their Property Characterization

Cao, Hongyan; Guo, Fenghao; Chen, Zhiyong; Kong, Xiang Zheng

doi:10.1186/s11671-018-2610-6

Cited by 19 publications

(14 citation statements)

References 48 publications

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“…Some polymers with the LCST/UCST switching behaviors by changing solvents, like PNIPAM, were also reported [10][11][12]. Besides, the addition of salt induced the switching of the LCST/UCST behaviors of these LCST/UCST diblock polymers [5,6,[13][14][15]. Due to the fact that the control of these phase transition temperatures is important for the application of thermosensitive polymers, various kinds of polymers have been studied [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Control of Stimuli Sensitivity in pH-Switchable LCST/UCST-Type Thermosensitive Dendrimers by Changing the Dendrimer Structure

Kojima

Tamaki

2022

Polymers

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Stimuli-sensitive materials, such as pH- and temperature-responsive polymers, are useful as smart materials. Phenylalanine (Phe)-modified polyamidoamine (PAMAM) dendrimers with succinic acid termini, PAMAM-Phe-Suc, have been reported as unique pH-switchable lower critical solution temperature (LCST)-/upper critical solution temperature (UCST)-type thermosensitive polymers. Regulating the phase transition behavior of dendrimers is important for their applications. This study investigated the relationship between the dendrimer structure and stimuli sensitivity. Phe-modified PAMAM dendrimers with cyclohexanedicarboxylate termini (PAMAM-Phe-CHex) and sulfonate termini (PAMAM-Phe-SO3Na) were synthesized. The temperature-dependent transmittance of these aqueous dendrimer solutions was examined at various pH values. PAMAM-Phe-CHex with Phe at all termini (PAMAM-Phe64-CHex) demonstrated a broad UCST-like phase transition at pH 7.0 but lacked an LCST-type phase transition. PAMAM-Phe-CHex with ≤ 27 Phe residues showed both LCST- and UCST-like phase transitions at different pH values, but the phase transition was broad. PAMAM-Phe-SO3Na showed both LCST- and UCST-type phase transitions at different pH values, and the transition temperature increased as the bound Phe number decreased. Thus, the phase transition behavior of PAMAM-Phe-SO3Na dendrimers can be regulated by varying the Phe/PAMAM ratios.

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Section: Introductionmentioning

confidence: 99%

“…LCST/UCST diblock polymers [5,6,[13][14][15]. Due to the fact that the control of these phase transition temperatures is important for the application of thermosensitive polymers, various kinds of polymers have been studied [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Control of Stimuli Sensitivity in pH-Switchable LCST/UCST-Type Thermosensitive Dendrimers by Changing the Dendrimer Structure

Kojima

Tamaki

2022

Polymers

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“…10 The LCST/UCST behaviors of poly(ethylene glycol diacrylate [OEGDA]-b-methacrylic acid [MAA]) were also switched by the content of alcohol in aqueous solution. 11 Interestingly, the LCST-type thermosensitive behaviors of PNIPAM in water were changed into the UCST-type in a binary aqueous solution containing alcohol and DMSO. 12 There are several reports on polymers with the LCST/UCST switching behaviors by changing solvents, like PNIPAM.…”

Section: Introductionmentioning

confidence: 99%

pH-Switchable LCST/UCST-type thermosensitive behaviors of phenylalanine-modified zwitterionic dendrimers

Tamaki

Kojima

2020

RSC Adv.

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Thermosensitive polymers are useful as intelligent materials. Dendrimers have well-defined structures, which can work as multifunctional polymers. In this study, we designed and synthesized various phenylalanine (Phe)-modified zwitterionic dendrimers as pH-and thermo-sensitive polymers. First, polyamidoamine (PAMAM) dendrimers were modified with Phe and succinic anhydride (Suc) to prepare carboxy-terminal Phe-modified dendrimers (PAMAM-Suc-Phe and PAMAM-Phe-Suc). Both these dendrimers showed upper critical solution temperature (UCST)-type thermosensitivity. Interestingly, PAMAM-Phe-Suc demonstrated lower critical solution temperature (LCST)-type thermosensitivity at lower pH, but PAMAM-Suc-Phe did not. This indicates that PAMAM-Phe-Suc can switch LCST/UCSTtype thermosensitivity according to the solution's pH. PAMAM-Phe-SO 3 Na with sulfonic acid termini also demonstrated LCST/UCST-type thermosensitivity switched by pH, with a higher sensitivity than PAMAM-Phe-Suc. Coacervation occurred during the phase separation. The quaternized dendrimers (QPAMAM-Phe-Suc and QPAMAM-Phe-SO 3 Na) and dendrimers conjugating isoleucine or 4-(amino methyl)benzoic acid did not show the unique thermosensitive properties, indicating that the tertiary amines in the dendrimer core and the Phe residues at the termini are indispensable. PAMAM-Phe-SO 3 Na could separate a model compound (rose bengal) from an aqueous solution because of its encapsulation ability. This is the first report of pH-switchable LCST/UCST-type thermosensitive dendrimers. 72 254 8190; Tel: +81 72 254 8190 † Electronic supplementary information (ESI) available: Experimental section; summary of synthesized dendrimers with different generations; NMR and FT-IR spectra of synthesized dendrimers; the pH titration proles; and temperature-dependent transmittance curves of obtained dendrimers under various conditions. See

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“…Such phenomenon was also attributed to the LCST-type thermoresponsive behavior of PNVCL that results in a phase transition from hydrated nanogels at 25°C to dehydrated nanogels starting at 35°C. Nanogels began to shrink at 35°C and caused the interaction between the nanogels more pronounced than their interaction with water molecules, which leads to the aggregation of the nanogels [ 28 ]. Thus, a larger particle size was observed above 35°C.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of dual-responsive poly(N-vinylcaprolactam-co-N-methylolacrylamide) nanogels

Nizardo

Alimin

Lestari

2022

Designed Monomers and Polymers

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This article reports the synthesis of poly(N-vinylcaprolactam-co-N-methylolacrylamide) (P(NVCL-co-NMA)) nanogels and investigates their thermo-/pH-responsive behavior. The formation of nanogels was synthesized using free radical emulsion polymerization by varying the monomer composition of NVCL:NMA, and their molecular structure was characterized by 1 H-NMR and FTIR. It was found that the nanogels were successfully prepared, and the nanogels exhibited LCST-type phase transition behavior. Cloud point transition temperature (T c ) was studied as a function of copolymer composition, MBA concentration, and pH of the solution by exploring their changes in turbidity using UV–vis spectrophotometer. Our studies reveal that T c nanogels increased with increasing concentration of NMA, which is due to the hydrophilicity of NMA. Our research also demonstrated that the increase in MBA percentage could decrease the T c of the synthesized nanogels. Interestingly, P(NVCL-co-NMA) nanogels showed not only a thermoresponsive behavior but also a pH response with increasing T c in a strong acidic environment owing to the H-bonds within the polymer chains. The results show that nanogels with initial monomer composition of NVCL and NMA of 75% and 25%, respectively, and using 4% of MBA showed T c around 35°C at pH 7.4. In addition, DLS studies also confirmed this result since the particle sizes became much larger after surpassing the temperature of 35°C. Due to this founding, such nanogels might have potential application in controlled release. Nevertheless, further studies regarding the adjustment of T c are still needed.

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Preparation of Thermoresponsive Polymer Nanogels of Oligo(Ethylene Glycol) Diacrylate-Methacrylic Acid and Their Property Characterization

Cited by 19 publications

References 48 publications

Control of Stimuli Sensitivity in pH-Switchable LCST/UCST-Type Thermosensitive Dendrimers by Changing the Dendrimer Structure

Control of Stimuli Sensitivity in pH-Switchable LCST/UCST-Type Thermosensitive Dendrimers by Changing the Dendrimer Structure

pH-Switchable LCST/UCST-type thermosensitive behaviors of phenylalanine-modified zwitterionic dendrimers

Synthesis and characterization of dual-responsive poly(N-vinylcaprolactam-co-N-methylolacrylamide) nanogels

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