Preparation of Thioamide Building Blocks via Microwave‐Promoted Three‐Component Kindler Reactions.

Abstract

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Microwave-Assisted Syntheses in Organic Chemistry

“…Another MW-assisted Kindler reaction was reported by Kappe and co-workers (Scheme 2.43) [73]. The three-component condensation of aldehydes, amines and elemental sulfur leading to thioamides 54 was performed using 1-methyl-2-pyrrolidone (NMP) as the solvent at 110-180°C for 2-20 min.…”

Solvent-Free Conversion of Thioamides to Thioesters

“…Starting thioamides were readily obtained by the Willgerodt-Kindler reaction of the corresponding benzaldehydes. [26] Thin-layer chromatography (TLC) was performed on ultraviolet (UV)-active aluminum-backed plates of silica gel (TLC silica gel 60 F 254 ). Flash chromatography was performed using silica gel (60 Å , 230-400 mesh) with reagent-grade solvents.…”

“…The study was started by examining the reaction of thioamide 1a as a test thioamide starting material, prepared by one of the known methods [26] with 4-nitrobenzyl bromide 2a and in various reaction conditions to produce the corresponding S-4-nitrobenzyl benzothioate 3a (Scheme 1).…”

L-Proline: An Efficient and Selective Catalyst for Transamidation of Thioamides with Amines

“…Recently, functionalized-thioamide fluorescent dyes were also employed as metal ion sensors [13]. Diverse synthetic methods have been discovered for the synthesis of thioamides [14][15][16][17][18][19][20][21][22][23].…”