Preparation of triamcinolone acetonide-loaded chitosan/fucoidan hydrogel and its potential application as an oral mucosa patch

Zheng, Wei; Hao, Yuanping; Wang, Danyang; Huang, Hailin; Guo, Fangze; Sun, Zhongyang; Shen, Peili; Sui, Kunyan; Yuan, Cheng; Zhou, Qihui

doi:10.1016/j.carbpol.2021.118493

Cited by 80 publications

(45 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the past few decades, marine polysaccharides have gained increasing attention in the area of diversified biomedical applications owing to their inherent (bio)physicochemical features, such as biocompatibility, biodegradability, favorable bioactive, biomechanical properties, and structural functionalities (Bidarra et al, 2014;Fernando et al, 2019;Hao et al, 2020;Jana et al, 2020;Yin et al, 2021;Zheng et al, 2021). Particularly, sulfated polysaccharide fucoidan, extracted from marine brown seaweed, has been well-known to possess various biological activities, e.g., antibacterial, antiviral, antioxidant, anticoagulant, anti-inflammatory, antitumor, antithrombotic, antifibrotic, and immunomodulatory activities, facilitating the generation of angiogenesis and fibrillar collagen matrix (Li et al, 2008;Senthilkumar et al, 2017;Oka et al, 2020;Yao et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

Chen

Zhu

Hao

et al. 2021

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Sulfated polysaccharide fucoidan (FD) is widely applied in biomedical applications owing to its outstanding bioactivities. In addition to the biochemical features, the architecture of biomaterials plays a critical role in tissue repair and regeneration. Particularly, nanofibers have elicited great interest due to their extracellular matrix-like structure, high specific surface area, and favorable biological properties. Herein, chitosan-modified FD/ultra-high molecular weight polyethylene oxide (UHMWPEO) nanofibers are developed via green electrospinning and electrostatic interaction for studying their interaction with endothelial cells. The appropriate solvent is screened to dissolve FD. The electrospinnability of FD/UHMWPEO aqueous solutions is greatly dependent on the weight ratios of FD/UHMWPEO. The incorporation of UHMWPEO significantly improves the electrospinnability of solution and thermo-stability of nanofibers. Also, it is found that there is good miscibility or no phase separation in FD/UHMWPEO solutions. In vitro biological experiments show that the chitosan-modified FD/UHMWPEO nanofibers greatly facilitate the adhesion of endothelial cells and inhibit the attachment of monocytes. Thus, the designed FD-based nanofibers are promising bio-scaffolds in building tissue-engineered blood vessels.

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

Chen

Zhu

Hao

et al. 2021

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Briefly, HPAEpi cells were seeded into a 96-well plate (1×10 4 cells/well, 100 μl/well) and cultured in RPMI1640 supplemented with 10% FBS and 1% P/S for 24 h. The cells were then incubated with 20, 100, 500, or 1,000 μg/ml of CAT-PEG for 24 h, respectively. The cell viability was then assessed using CCK-8 Kit ( Hao et al, 2021 ; Zheng et al, 2021 ), and measured the absorbance at 450 nm by a plate reader. The viability of untreated cells was used as 100% during the data analysis.…”

Section: Methodsmentioning

confidence: 99%

An Antioxidant Enzyme Therapeutic for Sepsis

Yan

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Sepsis is a systemic inflammatory response syndrome caused by infections that may lead to organ dysfunction with high mortality. With the rapid increase in the aging population and antimicrobial resistance, developing therapeutics for the treatment of sepsis has been an unmet medical need. Excessive production of reactive oxygen species (ROS) during inflammation is associated with the occurrence of sepsis. We report herein a treatment for sepsis based on PEGylated catalase, which can effectively break down hydrogen peroxide, a key component of ROS that is chemically stable and able to diffuse around the tissues and form downstream ROS. PEGylated catalase can effectively regulate the cytokine production by activated leukocytes, suppress the elevated level of AST, ALT, TNF-α, and IL-6 in mice with induced sepsis, and significantly improve the survival rate.

show abstract

“…To further improve the bactericidal characteristics, the combination of nano-ZnO and other antimicrobial agents has been extensively studied. Recently, surface functionalization with organic antimicrobial agents has also been considered to obtain antibacterial properties on Ti surfaces [ 126 , 127 ]. Antibacterial N-halamine polymers and related coatings have been widely studied in the past decade because of their strong broad-spectrum antibacterial activity against microorganisms, long-term chemical stability, renewability, biosafety, environmental friendliness and low cost [ 78 ].…”

Section: Antimicrobial Activity Of Nano-zno Modified Ti Implantsmentioning

confidence: 99%

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Wang

et al. 2021

J Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

Titanium (Ti) implants are widely used in dentistry and orthopedics owing to their excellent corrosion resistance, biocompatibility, and mechanical properties, which have gained increasing attention from the viewpoints of fundamental research and practical applications. Also, numerous studies have been carried out to fine-tune the micro/nanostructures of Ti and/or incorporate chemical elements to improve overall implant performance. Zinc oxide nanoparticles (nano-ZnO) are well-known for their good antibacterial properties and low cytotoxicity along with their ability to synergize with a variety of substances, which have received increasingly widespread attention as biomodification materials for implants. In this review, we summarize recent research progress on nano-ZnO modified Ti-implants. Their preparation methods of nano-ZnO modified Ti-implants are introduced, followed by a further presentation of the antibacterial, osteogenic, and anti-corrosion properties of these implants. Finally, challenges and future opportunities for nano-ZnO modified Ti-implants are proposed. Graphical Abstract

show abstract

Preparation of triamcinolone acetonide-loaded chitosan/fucoidan hydrogel and its potential application as an oral mucosa patch

Cited by 80 publications

References 49 publications

Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

Preparation of Fucoidan-Based Electrospun Nanofibers and Their Interaction With Endothelial Cells

An Antioxidant Enzyme Therapeutic for Sepsis

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Contact Info

Product

Resources

About