Preparation of α,α‐difluoromethylene functionalized sulfones

Abstract

Sulfination

Facile synthesis of α,α-difluoroalkyl aryl thioethers and their oxidative desulfurization–fluorination to trifluorides

“…By way of example, Yagupolskii et al obtained ethyl 2,2-difluoro-2-(phenylthio)acetates by nucelophilic substitution of ethyl difluoroiodoacetate with thiophenols in the presence of a base [12b]. Also ethyl bromodifluoroacetate was successfully applied to synthesize the latter compound [14]. Furthermore, the Na 2 S 2 O 4 mediated addition of difluoroiodomethylsulfanyl benzene to alkenes and alkynes gave 2,2-difluoro-4-iodoalkyl aryl sulfides [15].…”