Preparation, Physicochemical Characterization and Anti-fungal Evaluation of Nystatin-Loaded PLGA-Glucosamine Nanoparticles

Mohammadi, Ghobad; Shakeri, Amineh; Fattahi, Ali; Mohammadi, Pardis; Mikaeili, Ali; Aliabadi, Alireza; Adibkia, Khosro

doi:10.1007/s11095-016-2062-6

Cited by 21 publications

(8 citation statements)

References 40 publications

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“…Another possible strategy is using nanotechnology to modify or encapsulate currently used antifungal agents to improve their efficacy. To date, several nanomaterials have been investigated and presented as innovative antifungal agents, which include biodegradable polymeric and co-polymeric-based structures, metallic nanoparticles, metallic nanocomposites, and lipid-based nanosystems [ 114 , 115 , 116 ]. Additionally, the size range of nanoparticles endows them with the ability to deliver current antifungal agents by various routes of administration, such as oral, nasal, and intraocular routes [ 117 ].…”

Section: Unsatisfactory Properties Of Currently Used Antifungal Drugsmentioning

confidence: 99%

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Gao

Liu

et al. 2021

IJMS

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Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies.

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Section: Unsatisfactory Properties Of Currently Used Antifungal Drugsmentioning

confidence: 99%

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Gao

Liu

et al. 2021

IJMS

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“…Efforts to improve the absorption and permeability characteristics of nystatin have been undertaken [236]. For this, nystatin nanoparticles were developed by Mohammadi et al [237] for the purpose of systemic administration and increased uptake of the drug by microbial cells. The results showed that nystatin and PLA + glucosamide nanoparticles demonstrated appropriate antifungal activity and physicochemical characteristics.…”

Section: Nystatinmentioning

confidence: 99%

Nanoparticles as a Tool for Broadening Antifungal Activities

Renzi

Campos

Miranda

et al. 2021

CMC

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: The Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases, but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.

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“…[8] Nanoscale drug delivery platforms have proven to enhance the blood circulation time of antimicrobial agents, overcome the predominant issue of underdosing and minimize the arising adverse side effects. [17,82,83] Additionally, alternative antisepsis "nano"therapeutic strategies have been explored using NPs to enable a) lipopolysaccharide (LPS) neutralization, b) blood purification from inflammatory mediators, pathogens, and endotoxins, c) Toll-like receptors inhibition (TLR), and d) immune system modulation (immunomodulatory NPs). In the following section, we present the recent advancements of nanomedicine to combat sepsis disease.…”

Section: Nanotreatment Technologies For Sepsismentioning

confidence: 99%

Nanotools for Sepsis Diagnosis and Treatment

Papafilippou

Claxton

Dark

et al. 2020

Adv Healthcare Materials

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Sepsis is one of the leading causes of death worldwide with high mortality rates and a pathological complexity hindering early and accurate diagnosis. Today, laboratory culture tests are the epitome of pathogen recognition in sepsis. However, their consistency remains an issue of controversy with false negative results often observed. Clinically used blood markers, C reactive protein (CRP) and procalcitonin (PCT) are indicators of an acute‐phase response and thus lack specificity, offering limited diagnostic efficacy. In addition to poor diagnosis, inefficient drug delivery and the increasing prevalence of antibiotic‐resistant microorganisms constitute significant barriers in antibiotic stewardship and impede effective therapy. These challenges have prompted the exploration for alternative strategies that pursue accurate diagnosis and effective treatment. Nanomaterials are examined for both diagnostic and therapeutic purposes in sepsis. The nanoparticle (NP)‐enabled capture of sepsis causative agents and/or sepsis biomarkers in biofluids can revolutionize sepsis diagnosis. From the therapeutic point of view, currently existing nanoscale drug delivery systems have proven to be excellent allies in targeted therapy, while many other nanotherapeutic applications are envisioned. Herein, the most relevant applications of nanomedicine for the diagnosis, prognosis, and treatment of sepsis is reviewed, providing a critical assessment of their potentiality for clinical translation.

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Preparation, Physicochemical Characterization and Anti-fungal Evaluation of Nystatin-Loaded PLGA-Glucosamine Nanoparticles

Abstract: PLGA-GlcN nanoparticles showed more antifungal activity with appropriate physicochemical properties than pure Nystatin and PLGA nanoparticles.

Cited by 21 publications

References 40 publications

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Nanoparticles as a Tool for Broadening Antifungal Activities

Nanotools for Sepsis Diagnosis and Treatment

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