Preparation, physicochemical characterization and pharmacokinetics of paeoniflorin-phospholipid complex

Qian, Jiajia; Cheng, Weiye; Zhang, Caiyun; Hong, Lufeng; Chen, Weidong; Li, Guoxi

doi:10.3233/bme-181029

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…All measurements were in triplicate. The EE% was calculated according to the following Equation :

EE % = (1 - \frac{M_{0}}{M_{1}}) \times 100 %

where M 0 and M 1 are the weight of free DOX and total DOX in the system, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The prepared NPs powders were redispersed in deionized water and measured. All measurements were conducted in triplicate . The surface morphology of HA/Zein‐DOX NPs was observed by transmission electron microscope (TEM, Japan electronics corporation, JEM‐1400, Tokyo, Japan).…”

Section: Methodsmentioning

confidence: 99%

“…All measurements were in triplicate. The EE% was calculated according to the following Equation 1 [42] :…”

Section: Encapsulation Efficiency Of Dox In Ha/zein-dox Npsmentioning

confidence: 99%

“…All measurements were conducted in triplicate. [41][42][43] The surface morphology of HA/ Zein-DOX NPs was observed by transmission electron microscope (TEM, Japan electronics corporation, JEM-1400, Tokyo, Japan). HA/Zein-DOX NPs were gold coated (300 A) with an Edwards S150B sputter coater to improve electrical conductivity and observed under the SEM.…”

Section: Characterizationmentioning

confidence: 99%

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Preparation, characterization and preliminary pharmacokinetic study of pH-sensitive Hydroxyapatite/Zein nano-drug delivery system for doxorubicin hydrochloride

Zha

Wang

Qian

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Zein nanoparticles (Zein NPs) were used as a hydroxyapatite (HA) biomineralization template to generate HA/Zein NPs. Doxorubicin hydrochloride (DOX) was loaded on HA/Zein NPs (HA/Zein‐DOX NPs) to improve its pH‐sensitive release, bioavailability and decrease cardiotoxicity. Methods HA/Zein‐DOX NPs were prepared by phase separation and biomimetic mineralization method. Particle size, polydispersity index (PDI), Zeta potential, transmission electron microscope, X‐ray diffraction and Fourier‐transform infrared spectroscopy of HA/Zein‐DOX NPs were characterized. The nanoparticles were then evaluated in vitro and in vivo. Key findings The small PDI and high Zeta potential demonstrated that HA/Zein‐DOX NPs were a stable and homogeneous dispersed system and that HA was mineralized on Zein‐DOX NPs. HA/Zein‐DOX NPs showed pH‐sensitive release. Compared with free DOX, HA/Zein‐DOX NPs increased cellular uptake which caused 7 times higher in‐vitro cytotoxicity in 4T1 cells. Pharmacokinetic experiments indicated the t1/2β and AUC0–t of HA/Zein‐DOX NPs were 2.73‐ and 3.12‐fold higher than those of DOX solution, respectively. Tissue distribution exhibited HA/Zein‐DOX NPs reduced heart toxicity with lower heart targeting efficiency (18.58%) than that of DOX solution (37.62%). Conclusion In this study, HA/Zein‐DOX NPs represented an antitumour drug delivery system for DOX in clinical tumour therapy with improved bioavailability and decreased cardiotoxicity.

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“…All measurements were in triplicate. The EE% was calculated according to the following Equation :

EE % = (1 - \frac{M_{0}}{M_{1}}) \times 100 %

where M 0 and M 1 are the weight of free DOX and total DOX in the system, respectively.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…All measurements were in triplicate. The EE% was calculated according to the following Equation 1 [42] :…”

Section: Encapsulation Efficiency Of Dox In Ha/zein-dox Npsmentioning

confidence: 99%

Section: Characterizationmentioning

confidence: 99%

See 2 more Smart Citations

Preparation, characterization and preliminary pharmacokinetic study of pH-sensitive Hydroxyapatite/Zein nano-drug delivery system for doxorubicin hydrochloride

Zha

Wang

Qian

et al. 2020

Journal of Pharmacy and Pharmacology

Self Cite

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“…In recent decades, tremendous efforts have been paid to tackle the challenges. Among them, phospholipid complex (PC) is a common method to increase bioavailability of free drug, which has been confirmed by animal and clinical pharmacokinetics and activity studies (Mirzaei et al., 2017; Qian et al., 2018; Biswas et al., 2019; Qian et al., 2019). However, due to the high viscosity and poor water-solubility, the low dispersion and dissolution of PC in gastrointestinal (GI) fluid will limit drug’s absorption (Jiang et al., 2016; Yang et al., 2018).…”

Section: Introductionmentioning

confidence: 97%

Mechanisms of oral absorption improvement for insoluble drugs by the combination of phospholipid complex and SNEDDS

et al. 2019

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In the present study, a water insoluble drug named silybin was encapsulated into self-nanoemulsifying drug delivery system (SNEDDS) following the preparation of silybin-phospholipid complex (SB-PC), then several methods were carried out to characterize SB-PC-SNEDDS and elucidate its mechanisms to improve the oral absorption of SB. Using a dynamic in vitro digestion model, the lipolysis of SB-PC-SNEDDS was proved to be mainly related with the property of its lipid excipients. SB-PC-SNEDDS could significantly enhance the transport of SB across Caco-2 cells, which may partly attribute to the increased cell membrane fluidity and the loss of tight junction according to the analysis results of fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene (DPH) and tight junction protein (ZO-1). The result of in situ perfusion showed the intestinal absorption of SB from high to low was SB-PC-SNEDDS, SB-PC, and SB. The extent of lymphatic transport of SB-PC and SB-PC-SNEDDS via the mesenteric duct was 12.2 and 22.7 folds of that of SB, respectively. In the lymph duct cannulated rats, the relative bioavailability (Fr) of SB-PC and SB-PC-SEDDS compared to SB was 1265.9% and 1802.5%, respectively. All the above results provided mechanistic support for oral absorption improvement of water insoluble drugs by the combination of PC and SNEDDS.

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Fabrication of oral nanovesicle in-situ gel based on Epigallocatechin gallate phospholipid complex: Application in dental anti-caries

Dai

Zhang

et al. 2021

European Journal of Pharmacology

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Preparation, physicochemical characterization and pharmacokinetics of paeoniflorin-phospholipid complex

Cited by 8 publications

References 21 publications

Preparation, characterization and preliminary pharmacokinetic study of pH-sensitive Hydroxyapatite/Zein nano-drug delivery system for doxorubicin hydrochloride

Preparation, characterization and preliminary pharmacokinetic study of pH-sensitive Hydroxyapatite/Zein nano-drug delivery system for doxorubicin hydrochloride

Mechanisms of oral absorption improvement for insoluble drugs by the combination of phospholipid complex and SNEDDS

Fabrication of oral nanovesicle in-situ gel based on Epigallocatechin gallate phospholipid complex: Application in dental anti-caries

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