Preparation, Phytochemical Investigation, and Safety Evaluation of Chlorogenic Acid Products from Eupatorium adenophorum

Liu, Boyan; Cao, Lili; Zhang, Lijun; Yuan, Xiaofan; Zhao, Bing

doi:10.3390/molecules22010067

Cited by 17 publications

(6 citation statements)

References 40 publications

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“…Used as an anti-inflammatory, blood coagulant, antimicrobial, antiseptic, and analgesic, antipyretic. Isomers of mono-caffeoylquinic acid present in E. adenophoium exhibit potent anti-inflammatory, anti-bacterium, and anti-obesity properties [50].…”

Section: Eupoterium Adenophoium Asteraceaementioning

confidence: 99%

Evaluation of Phytochemical, Antioxidant and Antibacterial Activities of Selected Medicinal Plants

Shresta¹,

Bhandari²,

Aryal³

et al. 2021

Nepal J Biotechnol

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Medicinal plants are important reservoirs of bioactive compounds that need to be explored systematically. Because of their chemical diversity, natural products provide limitless possibilities for new drug discovery. This study aimed to investigate the biochemical properties of crude extracts from fifteen Nepalese medicinal plants. The total phenolic contents (TPC), total flavonoid contents (TFC), and antioxidant activity were evaluated through a colorimetric approach while the antibacterial activities were studied through the measurement of the zone of inhibition (ZoI) by agar well diffusion method along with minimum inhibitory concentrations (MIC) by broth dilution method. The methanolic extracts of Acacia catechu and Eupoterium adenophorum showed the highest TPC (55.21 ± 11.09 mg GAE/gm) and TFC (10.23 ± 1.07 mg QE/gm) among the studied plant extracts. Acacia catechu showed effective antioxidant properties with an IC50 value of 1.3 μg/mL, followed by extracts of Myrica esculenta, Syzygium cumini, and Mangifera indica. Morus australis exhibited antibacterial activity against Klebsiella pneumoniae (ZoI: 25mm, MIC: 0.012 mg/mL), Staphylococcus aureus ATCC 25923 (ZoI: 22 mm, MIC: 0.012 mg/mL), Pseudomonas aeruginosa (ZoI; 20 mm, MIC: 0.05 mg/mL), and methicillin-resistant Staphylococcus aureus (MRSA) (ZoI: 19 mm, MIC: 0.19 mg/mL). Morus australis extract showed a broad-spectrum antibacterial activity, followed by Eclipta prostrata, and Hypericum cordifolium. Future study is recommended to explore secondary metabolites of those medicinal plants to uncover further clinical efficacy.

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Section: Eupoterium Adenophoium Asteraceaementioning

confidence: 99%

Evaluation of Phytochemical, Antioxidant and Antibacterial Activities of Selected Medicinal Plants

Shresta¹,

Bhandari²,

Aryal³

et al. 2021

Nepal J Biotechnol

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show abstract

“…A statistical analysis conducted by Tajabadi et al [ 15 ] found that 70% of the 15,822 scaffolds belonging to natural products (NPs) are non-flat and represent an interesting resource for the design of new synthetic molecules [ 16 ]. Among such saturated ring systems, the pyrrolidine moiety is represented widely in NPs, especially in alkaloids isolated from plants or microorganisms [ 17 – 19 ] (Fig. 2 ) showing different biological activities, e.g.…”

Section: Introductionmentioning

confidence: 99%

Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds

et al. 2021

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The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of human diseases. The great interest in this saturated scaffold is enhanced by (1) the possibility to efficiently explore the pharmacophore space due to sp3-hybridization, (2) the contribution to the stereochemistry of the molecule, (3) and the increased three-dimensional (3D) coverage due to the non-planarity of the ring—a phenomenon called “pseudorotation”. In this review, we report bioactive molecules with target selectivity characterized by the pyrrolidine ring and its derivatives, including pyrrolizines, pyrrolidine-2-one, pyrrolidine-2,5-diones and prolinol described in the literature from 2015 to date. After a comparison of the physicochemical parameters of pyrrolidine with the parent aromatic pyrrole and cyclopentane, we investigate the influence of steric factors on biological activity, also describing the structure–activity relationship (SAR) of the studied compounds. To aid the reader’s approach to reading the manuscript, we have planned the review on the basis of the synthetic strategies used: (1) ring construction from different cyclic or acyclic precursors, reporting the synthesis and the reaction conditions, or (2) functionalization of preformed pyrrolidine rings, e.g., proline derivatives. Since one of the most significant features of the pyrrolidine ring is the stereogenicity of carbons, we highlight how the different stereoisomers and the spatial orientation of substituents can lead to a different biological profile of drug candidates, due to the different binding mode to enantioselective proteins. We believe that this work can guide medicinal chemists to the best approach in the design of new pyrrolidine compounds with different biological profiles.

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“…(Cao et al, 2020; Wang et al, 2018). Researchers have demonstrated the antioxidant and antitumour effects of CGA; it also exhibits a therapeutic effect on type II diabetes mellitus (Gao et al, 2019; Kang et al, 2013; Williamson, 2020), and its safety has been proven (Amano et al, 2019; Liu et al, 2016). In addition, CGA exerts an anti‐inflammatory effect by inhibiting NF‐κB and p38 signalling pathways and the release of reactive oxygen specific (Chen et al, 2018; Palócz et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic acid reduces inflammation by inhibiting the elevated expression of KAT2A to ameliorate lipopolysaccharide‐induced acute lung injury

Guo

et al. 2023

British J Pharmacology

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Background and Purpose: Respiratory diseases have become a global health problem and may lead to acute lung injury (ALI) in severe cases. ALI progression is associated with complex pathological changes; however, there are currently no effective therapeutic drugs. Excessive activation and recruitment of immunocytes in the lungs and the release of large amounts of cytokines are considered the primary causes of ALI, but the cellular mechanisms involved remain unknown. Therefore, new therapeutic strategies need to be developed to control the inflammatory response and prevent the further aggravation of ALI.Experimental Approach: Lipopolysaccharide was administered to mice via tail vein injection to establish an ALI model. Key genes regulating lung injury in mice were screened by RNA sequencing (RNA-seq), and their regulatory effects on inflammation and lung injury were assessed in in vivo and in vitro experiments.

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Preparation, Phytochemical Investigation, and Safety Evaluation of Chlorogenic Acid Products from Eupatorium adenophorum

Cited by 17 publications

References 40 publications

Evaluation of Phytochemical, Antioxidant and Antibacterial Activities of Selected Medicinal Plants

Evaluation of Phytochemical, Antioxidant and Antibacterial Activities of Selected Medicinal Plants

Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds

Chlorogenic acid reduces inflammation by inhibiting the elevated expression of KAT2A to ameliorate lipopolysaccharide‐induced acute lung injury

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