Preparation, properties and controlled release behaviors of pH-induced thermosensitive amphiphilic gels

Liu, Yuyang; Shao, Ying-Hui; Lü, Jian

doi:10.1016/j.biomaterials.2006.02.042

Cited by 93 publications

(78 citation statements)

References 40 publications

(166 reference statements)

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“…Recent developments on pNiPAAm-based hydrogels include their use for drug delivery [12,13,37,38], cell encapsulation and delivery [39,40] and cell culture surfaces [41]. Poly(Nisopropylacrylamide) is non-biodegradable and exhibits a sharp phase transition, with an LCST at about 32°C in pure water [37,42].…”

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

“…The hydrogel potential of NiPAAM copolymers with acrylic (AA) [12,39] and propylacrylic acid (PAA) [13] was examined. The thermoreversible p(NiPAAm-co-AA) hydrogel was tested as a cell and drug delivery vehicle.…”

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

“…This hydrogel in combination with the differentiation and growth factors holds promise for cartilage tissue engineering [39]. Liu [12] et al have synthesized p(NiPAAm-co-AA) and polymerized it with ethyl acrylate (EA) using the interpenetrating polymer network (IPN) technology. An interpenetrating polymer network is formed by hydrophilic and hydrophobic networks that are only physically interconnected, without any chemical bonding, so that individual components retain their original properties.…”

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

“…P(NiPAAm-co-AA) showed an initial burst release, which was not observed on p(pNiPAAm-co-AA)/pEA IPN. It was concluded that the pEA chains in the IPN structure had a favorable effect in maintaining a slower and more stable release profile [12]. Also, copolymers of NiPAAm with propylacrylic acid (PAA) show a temperature and pH-sensitive behavior.…”

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

“…In contrast, hydrogels that are formed upon cooling of a polymer solution have an upper critical solution temperature (UCST) [10]. The sol-gel transition of thermosensitive hydrogels can be experimentally verified by a number of techniques such as spectroscopy [11][12][13], differential scanning calorimetry (DSC) [11,12] and rheology [11].…”

Section: Introductionmentioning

confidence: 99%

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Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,135

696

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Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied. Thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factor. These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration. The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The review focuses mainly on hydrogels based on natural polymers, N-isopropylacrylamide polymers, poly(ethylene oxide)-b-poly(propylene oxide)-bpoly(ethylene oxide) polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.

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Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

Section: N-isopropylacrylamide-based Systemsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thermoresponsive hydrogels in biomedical applications

Klouda

Mikos

2008

European Journal of Pharmaceutics and Biopharmaceutics

1,135

696

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Smart Gels

Bag

Saxena

2014

Kirk-Othmer Encyclopedia of Chemical Technology

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Stimuli‐responsive gels are known as smart gels. Such gels respond adaptively to a variety of external stimulation. Different classes of smart gels, according to the name of the stimulus, are thermoresponsive, pH‐responsive, photoresponsive, electroresponsive, magnetoresponsive gels, chemically activated gels, and others. Such smart gel materials are discussed in this article along with their synthesis, characterization, properties, and various applications such as drug delivery systems, thermoresponsive cell culture dishes, microfluidic gel photovoltaics, etc. The advantages and disadvantages of electroactive gels have been discussed for their application as actuators. Microporous and superporous gels, microgels/nanogels, shape‐memory and self‐healing gels, and fullerene (C 60 )‐containing nanostructured smart polymers/gels are also depicted in this article. The state‐of‐the‐art research and development of smart gels along with the opportunities and challenges of this emerging field of research are highlighted in this article.

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Stimulus‐Responsive Polymers at Nanointerfaces

Vasani

Cole

Ellis

et al. 2011

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Types of Stimulus‐Responsive Polymer Thermoresponsive Polymers LCST Polymers UCST Polymers p H ‐Responsive Polymers Polycations Polyanions Polyzwitterions Photoresponsive Polymers Dual and Multi‐Stimulus‐Responsive Polymers Generating Stimulus‐Responsive Interfaces Covalent Routes “Grafting‐From” Techniques “Grafting‐To” Techniques Noncovalent Routes Interfacing SRPs with Flat and Porous Substrates Nanoparticles and Nanotubes Silica, Metal, and Metal Oxide Nanoparticles Quantum Dots Micelles Liposomes Nanotubes Applications of Stimulus‐Responsive Polymers at Interfaces Controlled Drug Delivery Control of Biointerfacial Interactions Microfluidic Valves Molecular Separation Summary and Future Perspectives

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Preparation, properties and controlled release behaviors of pH-induced thermosensitive amphiphilic gels

Cited by 93 publications

References 40 publications

Thermoresponsive hydrogels in biomedical applications

Thermoresponsive hydrogels in biomedical applications

Smart Gels

Stimulus‐Responsive Polymers at Nanointerfaces

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