Preparation, standardisation and evaluation of hypoglycaemic effect of herbal formulation containing five ethnomedicinal plants in alloxan-induced hyperglycemic wistar rats

Sharma, Archana; Pal, Prosanta; Sarkar, Bapi Ray; Mohanty, JP; Bhutia, Sonam

doi:10.5958/0974-360x.2020.01044.6

Cited by 2 publications

(1 citation statement)

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“…This is due to the higher concentration of essential oil, the more active substances contained in the essential oil. The more dynamic content, the more disturbing the receptors on the surface of macrophage cells, so phagocytic activity will also decrease [33][34][35][36][37] .…”

Section: Discussionmentioning

confidence: 99%

The effect of Mahogany seeds extract (Swietenia mahagoni) on the quantity of macrophages in the Post-tooth extraction wound healing phase of Wistar Rats (Rattus norvegicus)

Budhy

Irmawati

Arundina

et al. 2023

RJPT

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Tooth extraction often cause tissue damage and wound. After tooth extraction, the wound healing process becomes a major concern because of many complications and makes patients feel the pain suffered. Lande et al. (2015) showed the prevalence of tooth extraction complications, including crown fracture (31.82%), root fracture (13.6%), dry socket (4%), swelling (2.27%), and bleeding (1.6%). Macrophages are a common inflammatory cell in wounds, and the local macrophage population shifts from pro-inflammatory (M1-like phenotypes) to anti-inflammatory (M2-like phenotypes), indicating to the start of the next healing phase. Various alternative materials can help the healing process of wounds, one of which is mahogany seeds. Flavonoids found in Mahagony seeds can influence cell function by boosting the synthesis of PDGF, VEGF, pro-inflammatory cytokines, activating monocytes, and raising the number of macrophages involved in the wound healing. Proving mahogany seed extract (Swietenia mahagoni) affects the number of macrophages in the wound healing process after extracting Wistar rat (Rattus norvegicus) teeth. 20 Wistar rats were divided into four groups there were one control group (K) performed tooth extraction without any treatment, and three treatment groups (P1, P2, P3) performed tooth extraction and topically induced with three different doses of mahogany seeds extract (50 mg/200g rbw, 100mg/200g rbw, 200mg/200g rbw) in the post-extraction socket. Wistar rats were sacrificed on the 3rd day. Observations were made by reading histologic preparations using Hematoksilin Eosin (HE) 400x light microscope magnification. The quantity of macrophages in each group differed significantly between 4 groups (p = 0.003), namely between K1 and P1 (p = 0.008), P1 and P3 (p = 0.001), P2 and P3 (p = 0.006). Mahogany seeds extract affects the wound healing process, with 50mg/200g rbw as the optimal dose

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Section: Discussionmentioning

confidence: 99%

The effect of Mahogany seeds extract (Swietenia mahagoni) on the quantity of macrophages in the Post-tooth extraction wound healing phase of Wistar Rats (Rattus norvegicus)

Budhy

Irmawati

Arundina

et al. 2023

RJPT

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In vitro screening on Alpha amylase and Alpha glucosidase inhibitory activities of some novel Quinazolinone derivatives

Modh

Patel

2022

RJPT

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Diabetes mellitus is a metabolic condition characterised by chronic hyperglycaemia, and type II diabetes is the most common type, accounting for 90% of cases globally. Hyperglycaemia is major complication of Diabetes mellitus. Postprandial hyperglycaemia is the most common distinctive of diabetes. Inhibition of carbohydrate hydrolysing enzymes including amylase and glucosidase may be useful method for lowering postprandial blood sugar levels. Alpha amylase and glucosidase inhibitors are the most approaching targets in the development of lead compounds for the treatment and management of diabetes. This type of inhibitors, used in clinical practise for the treatment of diabetes are known to be associated with gastrointestinal side effects. Therefore, we need to synthesize new compounds which have fewer side effects. In present study synthesized thirty quinazolinone compounds (PM1-PM30) were screened for their inhibitory effect on alpha amylase and alpha glucosidase enzymes. All synthesized compounds PM1 to PM 30, possess good inhibitory activity similar to that of approved drug Acarbose. Compounds PM20 PM7, PM28, PM29 are remarkable potent alpha amylase inhibitors and compounds PM30, PM28, PM29, PM4 are remarkable potent alpha glucosidase inhibitors. Therefore, these compounds are beneficial for management and treatment of diabetes disorder.

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Preparation, standardisation and evaluation of hypoglycaemic effect of herbal formulation containing five ethnomedicinal plants in alloxan-induced hyperglycemic wistar rats

Cited by 2 publications

References 0 publications

The effect of Mahogany seeds extract (Swietenia mahagoni) on the quantity of macrophages in the Post-tooth extraction wound healing phase of Wistar Rats (Rattus norvegicus)

The effect of Mahogany seeds extract (Swietenia mahagoni) on the quantity of macrophages in the Post-tooth extraction wound healing phase of Wistar Rats (Rattus norvegicus)

In vitro screening on Alpha amylase and Alpha glucosidase inhibitory activities of some novel Quinazolinone derivatives

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