Preparative Chromatography

Mihlbachler, Kathleen; Dapremont, Olivier

doi:10.1002/9780470711828.ch22

Green Techniques for Organic Synthesis and Medicinal Chemistry 2012

DOI: 10.1002/9780470711828.ch22

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Preparative Chromatography

Kathleen Mihlbachler

Olivier Dapremont

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Cited by 3 publications

References 14 publications

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Preparative Chromatography for Production

Dapremont

2021

Burger's Medicinal Chemistry and Drug Discovery

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The article introduces the reader to preparative chromatography as a purification tool for the manufacturing of active pharmaceutical ingredients (APIs). In a first part, the history of the development of chromatography as a separation technique is reviewed and concepts associated with the process development and its modeling are introduced. In a second section, the various techniques used to optimize a preparative separation for production are reviewed. Aspects of the various phases of the process development from early clinical phase up to commercial manufacturing are discussed with emphasis on intellectual property, solvent considerations, and separation robustness. Scale‐up rules are also introduced at the end of the section. Finally, the author discusses the implementation of a chromatographic step at commercial scale; handling of the chromatographic packing material and plant operations are more specifically highlighted.

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Preparative Chromatography for Production

Dapremont

2021

Burger's Medicinal Chemistry and Drug Discovery

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Multicolumn Continuous Chromatography: Understanding this Enabling Technology

Mihlbachler

2017

Continuous Biomanufacturing ‐ Innovative Technologies and Methods

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Active Pharmaceutical Ingredient Cost of Goods: Discovery to Early Development

Anderson¹,

Nelson

2018

Early Drug Development

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Preparative Chromatography

Cited by 3 publications

References 14 publications

Preparative Chromatography for Production

Preparative Chromatography for Production

Multicolumn Continuous Chromatography: Understanding this Enabling Technology

Active Pharmaceutical Ingredient Cost of Goods: Discovery to Early Development

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