Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography

Liu, Renmin; Li, Aifeng; Sun, Ailing; Kong, Ling–Yi

doi:10.1016/j.chroma.2004.09.049

Cited by 73 publications

(44 citation statements)

References 12 publications

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“…Each peak fraction was collected according to the chromatogram and evaporated under reduced pressure. The results of HSCCC tests indicated that n-hexane-ethyl acetate-methanol-water (5:5:4.5:5.5, v/v) was the best solvent system for the separation of psoralen and isopsoralen (Liu et al, 2004b).…”

Section: Hyphenated Hplc Techniquesmentioning

confidence: 99%

“…As an advanced separation technique, it offers various advantages including high sample recovery, high-purity of fractions, and high-loading capacity (Ma et al, 1994). In the past 30 years, HSCCC has made great progress in the preparation of various reference standards for pharmacological studies and good manufacturing practice, such as coumarins, alkaloids, flavonoids, hydroxyanthraquiones (Liu et al, 2004b). …”

Section: Hyphenated Hplc Techniquesmentioning

confidence: 99%

“…The column used was a reversed-phase symmetry C18 column. (Liu et al, 2004(Liu et al, , 2004a(Liu et al, , 2004b. Bergapten and imperatorin obtained by HSCCC method from Cnidium monnieri were also analyzed by high-performance liquid chromatography.…”

Section: Hyphenated Hplc Techniquesmentioning

confidence: 99%

See 2 more Smart Citations

Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material

Szewczyk¹,

Kocka²

2012

Phytochemicals - A Global Perspective of Their Role in Nutrition and Health

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Section: Hyphenated Hplc Techniquesmentioning

confidence: 99%

Section: Hyphenated Hplc Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material

Szewczyk¹,

Kocka²

2012

Phytochemicals - A Global Perspective of Their Role in Nutrition and Health

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“…Boh-gol zhee in Korea [11] , Buguzhi in Chinese [12], Barachi, Bavochi, hakuch and latakasturi in Bengal, babchi, bavacha Bawachi in Gujarat. It is also called Bavachya, babchi, bavachi (Marathi) waghchi (Presion); Karpokarishi, Karpurvarishi (Tamil); Bhavanji, Kalangiya, Karubogi, Koriasthan (Telugu).…”

Section: Fig :1 Plant In Vegetative Phasementioning

confidence: 99%

The Botany, Chemistry, Pharmacological and Therapeutic Application of Psoralea corylifolia L. – A Review

Uikey¹,

Yadav²,

Sharma³

et al. 2010

int j phytomed

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Psoralea corylifolia Linn. is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the world. Its medicinal usage is reported in Indian pharmaceutical codex, the Chinese, British and the American pharmacopoeias and in different traditional system of medicines such as Ayurveda, Unani and Siddha. The review reveals that wide ranges of phytochemical constituents have been isolated from the plant and it possesses important activities like antibacterial, antiinflammatory and antitumer. Various other activities like hepatoprotective, antioxidants and antithelminitic have also been reported. These repots are very encouraging and indicate that herb should be studied more expensively for its therapeutic benefits.This article briefly reviews the botany, pharmacology, biochemistry and therapeutic application of the plant. This is an attempt to compile and document information on different aspects of Psoralea corylifolia and highlight the need for research and development.

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“…In recent years, many studies focused on analyses of its quality, 1-3) phytochemistry, 4,5) and bioactivities.6-18) Our liquid chromatography mass spectroscopy (LC-MS) analyses on the chemical profile of the fruits led to the discoveries of two benzofuran glycosides. They were isolated and identified to be the glucosides of psoralen and isopsoralen by detailed spectral analyses, respectively, along with nine known compounds.…”

mentioning

confidence: 99%

Psoralenoside and Isopsoralenoside, Two New Benzofuran Glycosides from Psoralea corylifolia

Qiao

Han

et al. 2006

Chem. Pharm. Bull.

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The fruits of Psoralea corylifolia L. (Fabaceae), wellknown as a traditional Chinese medicine "Buguzhi", are widely applied for the cure of gynaecological bleeding, vitiligo and psoriasis. In recent years, many studies focused on analyses of its quality, 1-3) phytochemistry, 4,5) and bioactivities.6-18) Our liquid chromatography mass spectroscopy (LC-MS) analyses on the chemical profile of the fruits led to the discoveries of two benzofuran glycosides. They were isolated and identified to be the glucosides of psoralen and isopsoralen by detailed spectral analyses, respectively, along with nine known compounds.In the MeOH extract of the fruits of Psoralea corylifolia, two interesting compounds (1, 2) were found by high performance liquid chromatography (HPLC) analyses. They were shown as major peaks in the HPLC chromatogram, but had never been reported. Moreover, they were absent in the boiled water extract of the fruits, but their polarity was close to sugar. The high performance liquid chromatography electrospray ionization mass spectroscopy (HPLC-ESI-MS) analyses showed that they presented the same MS spectra, in which three major ion peaks were displayed clearly. As shown in Fig. 1 Two new benzofuran glycosides, called psoralenoside and isopsoralenoside, were isolated from the fruits of Psoralea corylifolia, together with nine known compounds. Their structures were elucidated by detailed spectral analyses including extensive two dimensional (2D) NMR spectra.

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Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography

Cited by 73 publications

References 12 publications

Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material

Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material

The Botany, Chemistry, Pharmacological and Therapeutic Application of Psoralea corylifolia L. – A Review

Psoralenoside and Isopsoralenoside, Two New Benzofuran Glycosides from Psoralea corylifolia

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