Preparative purification of the major anti-inflammatory triterpenoid esters from Marigold (Calendula officinalis)

Hamburger, Matthias; Adler, Sven; Baumann, Dietmar; Förg, Alexander; Weinreich, Bernd

doi:10.1016/s0367-326x(03)00051-0

Cited by 116 publications

(77 citation statements)

References 15 publications

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“…This result upholds the finding of Sidhu et al (1999). It may be due to the anti-inflammatory ability of marigold flower (Hamburger et al, 2003) and turmeric (Aggarwal et al, 2003) respectively. However, reactive cells are seen in wounds treated with povidoine iodine till day 7 (D7) (Figure 6c).…”

Section: Resultscontrasting

confidence: 50%

Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: A comparative approach

Paul

Rahman²,

Mahmud

et al. 2017

J Adv Vet Anim Res

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Objective: This experiment was conducted to evaluate the therapeutic potency of marigold flower (Calendula officinalis) and turmeric (Curcuma longa) rhizome paste in wound healing. Materials and methods: Thirty six aseptic surgical wounds were tooled in six non-pregnant black Bengal goats dividing them in 3 groups. Month long information and follow-up examinations along with complications such as edema, wound dehiscence, suture abscess, exudation etc. were studied. Wound healing was assessed by observing some morphological characters as well as histopathological changes of the wounded area. Results: Results revealed that negligible elevation of suture line (1.17±0.11 mm) and significant (P<0.01) reduction of sutured area were observed in goats of turmeric group at day 3 (D3) and 7 (D7) respectively. Moreover, histologic appearance of wound of the similar group displayed splendid development of keratin layer and collagen fiber than the others from day 3 (D3). However, therapeutic efficacy of marigold flower paste was not up to the mark as turmeric in this experiment. Control group treated with povidone iodine, showed good results but took long time. Conclusion: This study could patronize veterinarians to consider the use of herbal plants specially turmeric as a great wound healer. It will also reduce toxicities created by haphazard use and applications of pharmaceutical products. The findings of this very experiment will not only prevent the skin degradation but also help to maintain the good health status of animals. KEYWORDS CORRESPONDENCE:# Sattwikesh Paul, Department of Surgery & Radiology, FVMAS, BSMRAU, Gazipur-1706. Bangladesh. E-mail: paulsattwik@gmail.com

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Section: Resultscontrasting

confidence: 50%

Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: A comparative approach

Paul

Rahman²,

Mahmud

et al. 2017

J Adv Vet Anim Res

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“…Além da utilização ornamental, tem uso culinário e terapêutico. Sua inflorescência é a parte da planta mais usada com fins terapêuticos, com ação cicatrizante, antiinflamatória e antisséptica (Martins et al, 2000;Hamburguer et al, 2003). Entre os constituintes químicos potencialmente ativos da calêndula, são citados óleo essencial, saponinas, flavonóides, carotenóides, mucilagens, resinas e princípio amargo.…”

Section: Introductionunclassified

Teor e rendimento de flavonóides em calêndula (Calendula officinalis L.) cultivada com diferentes lâminas de irrigação

Bortolo

Marques

Pacheco

2009

Rev. bras. plantas med.

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Palavras-chave: Calendula officinalis, manejo da irrigação, tanque classe A ABSTRACT: Flavonoid content and yield in marigold plant (Calendula officinalis L.) cultivated under different irrigation depths.Calendula officinalis L. presents ornamental, culinary and therapeutic use. Its inflorescence is used to heal and as an anti-inflammatory. This study analyzed the effect of four different irrigation depths under field conditions on flavonoid production in marigold plant (Calendula officinalis L.). The water depths were estimated based on the class A pan evaporation (CPE): 0, 50, 100 and 150% CPE; they were applied from the beginning of flowering to the end of the culture cycle. There were no statistical differences in flavonoid content. The highest values of flower dry weight and flavonoid yield were obtained with the treatment without irrigation. The highest proline content was found in the plants subjected to overwatering stress. The accumulated water deficit for the treatment without irrigation signalized possible death due to water deficit. As precipitation occurred in the pre-flowering, the plant, originated from Mediterranean, responded with an abundant flowering in mass and number of flowers. Thus, for Presidente Prudente (São Paulo State, Brazil), if there is no water replacement through precipitation, supplementary irrigation with 200 mm will be necessary only in the pre-flowering to induce maximum flowering and maximum flavonoid yield per hectare.

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“…Few experimental models have been carried out for the evaluation of the anti-inflammatory activity of the C. officinalis. One of these models was conducted by means of the induction of ear edema by croton oil and another one by the use of carrageenan-induced paw edema [4][5][6] . Patrick et al 7 carried out a study with European C. officinalis flowers by the use of the chorioallantoic membrane (CAM) of chicken fertilized egg.…”

Section: Introductionmentioning

confidence: 99%

Angiogenic activity of Calendula officinalis flowers L. in rats

Parente¹,

Andrade²,

Brito³

et al. 2011

Acta Cir. Bras.

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Purpose:In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors. Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization. Key words: Calendula. Wound Healing. Neovascularization, Physiologic. Plants, Medicinal. Rats. RESUMOObjetivo: Neste trabalho a atividade sobre a angiogênese do extrato etanólico (EEC) e das frações diclorometano e hexânica das flores de Calendula officinalis L. (Asteraceae) cultivada no Brasil foram avaliados, visto que propriedades medicinais têm sido atribuídas às flores da planta, destacando-se a atividade cicatrizante. Métodos: Modelos utilizando 36 ratos e 90 ovos embrionados foram usados para avaliar as atividades cicatrizante e angiogênica dos extratos e frações da planta, por meio da indução de feridas cutâneas e da membrana corioalantóide, respectivamente. O efeito proliferativo vascular foi também testado a partir do estudo imunoistoquímico, realizado para verificar a intensidade da expressão do fator de crescimento endotelial vascular (VEGF) na derme de ratos. Resultados: A atividade angiogênica do extrato e das frações foi evidenciada nos dois modelos experimentais empregados. Foi evidenciado que este efeito não estava diretamente relacionado à expressão do VEGF, podendo estar associado a outros fatores pró-angiogênicos. Conclusão: A atividade cicatrizante referida a C. officinalis está relacionada ao seu efeito positivo sobre a angiogênese, e este foi caracterizado pela indução de neovascularização. Descritores: Calendula. Cicatrização de Feridas. Neovascularização Fisiológica. Plantas Medicinais. Ratos.

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Preparative purification of the major anti-inflammatory triterpenoid esters from Marigold (Calendula officinalis)

Cited by 116 publications

References 15 publications

Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: A comparative approach

Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: A comparative approach

Teor e rendimento de flavonóides em calêndula (Calendula officinalis L.) cultivada com diferentes lâminas de irrigação

Angiogenic activity of Calendula officinalis flowers L. in rats

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