Preparative separation of menthol and pulegone from peppermint oil (Mentha piperita L.) by high-performance counter-current chromatography

Skalicka-Woźniak, Krystyna; Walasek, Magdalena

doi:10.1016/j.phytol.2014.06.007

Cited by 32 publications

(23 citation statements)

References 11 publications

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“…The study is similar to research by Kumar et al [52]. Reduction of LC 50 in periods of 24 or 48 hours (111.9 and 98.66 ppm) in the potential larvicide of the species was observed.…”

Section: Resultssupporting

confidence: 90%

“…Some studies detect the effects of the chemical composition of monoterpenes, as well as, some sesquiterpenes, which serve as repellents at toxicity significant to insects but negligible toxicity to mammals. Mixtures of these volatile low molecular weight compounds provide plants, such as Mentha piperita , Citrus limon , Ocimum basilicum , and Salvia officinalis, with their distinctive odor, which are commercially available, produced, and important ingredients for fragrance and flavor creation because of their specific sensory characteristics [52]. …”

Section: Resultsmentioning

confidence: 99%

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Chemical Composition andIn VitroAntioxidant, Cytotoxic, Antimicrobial, and Larvicidal Activities of the Essential Oil ofMentha piperitaL. (Lamiaceae)

Ramos

Rodrigues

Farias

et al. 2017

The Scientific World Journal

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The essential oil was obtained by hydrodistillation and the identification and quantification of components were achieved with the use of GC-MS analysis. The antioxidant activity was evaluated by the method of sequestration of DPPH. Essential oils were used for study the cytotoxic front larvae of Artemia salina. In the evaluation of the antimicrobial activity of essential oils, we employed the disk-diffusion method. The potential larvicide in mosquito larvae of the third stage of development of Aedes aegypti to different concentrations of essential oils was evaluated. The major compounds found in the essential oils of M. piperita were linalool (51.8%) and epoxyocimene (19.3%). The percentage of antioxidant activity was 79.9 ± 1.6%. The essential oil showed LC50 = 414.6 μg/mL front of A. saline and is considered highly toxic. It shows sensitivity and halos significant inhibition against E. coli. The essential possessed partial larvicidal efficiency against A. aegypti.

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“…The study is similar to research by Kumar et al [52]. Reduction of LC 50 in periods of 24 or 48 hours (111.9 and 98.66 ppm) in the potential larvicide of the species was observed.…”

Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Chemical Composition andIn VitroAntioxidant, Cytotoxic, Antimicrobial, and Larvicidal Activities of the Essential Oil ofMentha piperitaL. (Lamiaceae)

Ramos

Rodrigues

Farias

et al. 2017

The Scientific World Journal

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“…This technique is based on partitioning between two liquid phases, where one of the liquids is a stationary phase, which eliminates the frequently observed irreversible process of sample absorption during chromatographic processing (Skalicka-Woźniak & Garrard 2015). The technique is effective for the efficient and rapid purification of active compounds from plant extracts, and more importantly, for the smooth isolation of pure constituents from EO (Skalicka-Woźniak, Walasek, Ludwiczuk & Głowniak, 2013;Skalicka-Woźniak & Walasek 2014). The process was scaled from analytical to preparative format and allowed the preparation of sufficient quantities of purified terpenoids for our pharmacological studies.…”

Section: Introductionmentioning

confidence: 99%

The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study

Skalicka-Woźniak

Walasek

Aljarba³

et al. 2018

Food and Chemical Toxicology

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The high-performance counter-current chromatography was used for the efficient purification of single constituents from Thymus vulgaris essential oil. Mixtures of n-heptane, ethyl acetate, methanol, and water (5:2:5:2 and 4:1:4:1 v/v), allowed purification of eugenol, 1-octen-3- ol, borneol, thymol, terpinen-4-ol, and camphor, while n-hexane, acetonitrile, and tert-butyl methyl ether (1:1:0.1 v/v) yielded carvacrol, borneol, linalyl acetate, caryophyllene oxide, p-cymene, and eucalyptol. The anticonvulsant activities were evaluated in the maximal electroshock-induced seizure test in mice model (systemic i. p. administration). The oil exerted protection against MES-induced seizures when administered 15 and 30 min before the tests (50 and 62.5%, respectively). Among the isolates, borneol, thymol, and eugenol exerted the strongest protection against seizures. Moreover, linalool had the ability to reduce the transfer of the pKM101 plasmid by 84%, what has the potential to reduce virulence and resistance spread in E. coli. No acute toxic effects towards the CNS were noticed either for the essential oil or for single compounds, in the chimney and grip-strength tests. The preclinical screening of Thymus vulgaris EO, as well as isolated terpenoids, provides evidence that the EO has partial protective activity against seizures and HPCCC technique is suitable for its large scale isolation.

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“…GC-MS was performed as previously described [18]. A Shimadzu GC-2010 Plus GC coupled to a Shimadzu QP2010 Ultra mass spectrometer was used.…”

Section: Gc-ms Analysismentioning

confidence: 99%

“…com), and NIST MS data (http://webbook.nist.gov) [19]. Individual isolated compound identifications were also performed by comparison of their mass spectra and retention indices with authentic compounds and literature data [18].…”

Section: Gc-ms Analysismentioning

confidence: 99%

GC-MS fingerprints of mint essential oils

et al. 2015

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Essential oils from eleven Mentha species were obtained by Deryng hydrodistillation and analysed by GC-MS: 44 compounds were identified. The most abundant were menthone, isomenthone, menthol, carvone, piperitone oxide, D-limonene and eucalyptol. Chemometric similarity measures and principal component analysis were calculated, allowing comparisons based on secondary metabolite content. The fingerprints may be helpful in chemotaxonomy.

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Preparative separation of menthol and pulegone from peppermint oil (Mentha piperita L.) by high-performance counter-current chromatography

Cited by 32 publications

References 11 publications

Chemical Composition andIn VitroAntioxidant, Cytotoxic, Antimicrobial, and Larvicidal Activities of the Essential Oil ofMentha piperitaL. (Lamiaceae)

Chemical Composition andIn VitroAntioxidant, Cytotoxic, Antimicrobial, and Larvicidal Activities of the Essential Oil ofMentha piperitaL. (Lamiaceae)

The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study

GC-MS fingerprints of mint essential oils

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