In an effort to engineer damage-tolerant ingot metallurgy (IM) in situ titanium matrix composites with attractive mechanical properties, the fatigue and fracture properties of a range of high-modulus titanium alloys reinforced with TiB whiskers were examined. The strengthening effects due to elastic whisker reinforcement are quantified using shear lag and rule-of-mixture models. The effects of alloy composition and microstructure on the fatigue behavior of the in situ titanium composites will also be discussed.